DegronMD

Uniprot ID: Q02413

Source protein: Desmoglein-1

Source gene: DSG1

Class: CBL_PTK

Location: 523:532

E3 ligase: CBL

DEGRON score: 0.8014

ASA_SCORE: 54.89

COIL: 0.5696

CONS_SCORE: 0.5679

DSS_SCORE: 0.5826

HELIX: 0.0228

FCONS_SCORE: 0.9148

RIG_SCORE: 0.6681

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P532T	TCGA-97-A4M3	LUAD	TCGA	DSSQVYSSEP	CBL_PTK	0.7031
p.P532T	DO218937	LUAD	ICGC	DSSQVYSSEP	CBL_PTK	0.7031
p.G535E	TCGA-EE-A3JI	SKCM	TCGA	DSSQVYSSEP	CBL_PTK	0.25
p.G535E	DO47268	SKCM	ICGC	DSSQVYSSEP	CBL_PTK	0.25
p.V527E	TCGA-MN-A4N5	LUAD	TCGA	DSSQVYSSEP	CBL_PTK	0.6582
p.V527E	DO45332	LUAD	ICGC	DSSQVYSSEP	CBL_PTK	0.6582
p.T522S	TCGA-NC-A5HJ	LUSC	TCGA	DSSQVYSSEP	CBL_PTK	0.3056
p.T522S	DO219189	LUSC	ICGC	DSSQVYSSEP	CBL_PTK	0.3056
p.G533E	TCGA-UF-A719	HNSC	TCGA	DSSQVYSSEP	CBL_PTK	0.3056
p.G533E	DO52105	HNSC	ICGC	DSSQVYSSEP	CBL_PTK	0.3056
p.G533E	DO229446	SKCA	ICGC	DSSQVYSSEP	CBL_PTK	0.3056
p.K537R	DO48440	BLCA	ICGC	DSSQVYSSEP	CBL_PTK	0.3056
p.K537R	DO229005	COCA	ICGC	DSSQVYSSEP	CBL_PTK	0.3056
p.K537R	DO229346	LAML	ICGC	DSSQVYSSEP	CBL_PTK	0.3056
p.D538N	DO229005	COCA	ICGC	DSSQVYSSEP	CBL_PTK	0.1667
p.D538N	DO229346	LAML	ICGC	DSSQVYSSEP	CBL_PTK	0.1667
p.Y528S	DO229005	COCA	ICGC	DSSQVYSSEP	CBL_PTK	0.712
p.Y528S	DO229346	LAML	ICGC	DSSQVYSSEP	CBL_PTK	0.712
p.Y528S	DO52365	LUSC	ICGC	DSSQVYSSEP	CBL_PTK	0.712
p.S518N	DO233882	GACA	ICGC	DSSQVYSSEP	CBL_PTK	0.1944
p.D523Y	DO229015	LICA	ICGC	DSSQVYSSEP	CBL_PTK	0.7325
p.T519P	DO220907	MELA	ICGC	DSSQVYSSEP	CBL_PTK	0.6667
p.T513S	SIDM01096	Colorectal Carcinoma	GDSC	DSSQVYSSEP	CBL_PTK	0.0556
p.T513S	ACH-000400	Colon/Colorectal Cancer	CCLE	DSSQVYSSEP	CBL_PTK	0.0556
p.T513S	SK-CO-1	large_intestine	COSMIC	DSSQVYSSEP	CBL_PTK	0.0556
p.L539V	SIDM00234	Other Solid Cancers	GDSC	DSSQVYSSEP	CBL_PTK	0.1389
p.L539V	SIDM00315	Glioblastoma	GDSC	DSSQVYSSEP	CBL_PTK	0.1389
p.L539V	SIDM00530	Esophageal Carcinoma	GDSC	DSSQVYSSEP	CBL_PTK	0.1389
p.L539V	SIDM00351	Oral Cavity Carcinoma	GDSC	DSSQVYSSEP	CBL_PTK	0.1389
p.L539V	SIDM00251	Gastric Carcinoma	GDSC	DSSQVYSSEP	CBL_PTK	0.1389
p.L539V	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	DSSQVYSSEP	CBL_PTK	0.1389
p.L539V	SIDM00526	Chronic Myelogenous Leukemia	GDSC	DSSQVYSSEP	CBL_PTK	0.1389
p.L539V	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	DSSQVYSSEP	CBL_PTK	0.1389
p.L539V	SIDM01756	Chronic Myelogenous Leukemia	GDSC	DSSQVYSSEP	CBL_PTK	0.1389
p.L539V	SIDM01442	Glioma	GDSC	DSSQVYSSEP	CBL_PTK	0.1389
p.L539V	SIDM00497	Colorectal Carcinoma	GDSC	DSSQVYSSEP	CBL_PTK	0.1389
p.S525G	SIDM00699	Small Cell Lung Carcinoma	GDSC	DSSQVYSSEP	CBL_PTK	0.5882
p.S525G	ACH-001138	Lung Cancer	CCLE	DSSQVYSSEP	CBL_PTK	0.5882
p.S525G	NCI-H2141	lung	COSMIC	DSSQVYSSEP	CBL_PTK	0.5882

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSSQVYSSEP

Degron related mutations and impact score

Drug responses associated with DSG1 mutations

All proteins holding degron of DSSQVYSSEP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02413	Desmoglein-1	CBL_PTK	523:532	DSSQVYSSEP	CBL	0.8014	More...