DegronMD - Q02413(DSG1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G932S	TCGA-2W-A8YY	CESC	TCGA	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation rewiring degron network	0.1944
p.G932S	TCGA-EJ-A65E	PRAD	TCGA	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation rewiring degron network	0.1944
p.G932S	DO223732	CESC	ICGC	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation rewiring degron network	0.1944
p.G932S	DO49754	PRAD	ICGC	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation rewiring degron network	0.1944
p.G932S	SIDM00282	Colorectal Carcinoma	GDSC	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation rewiring degron network	0.1944
p.G932S	ACH-000998	Colon/Colorectal Cancer	CCLE	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation rewiring degron network	0.1944
p.S938C	TCGA-66-2788	LUSC	TCGA	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation altering degron motif	0.643
p.S938C	DO26749	LUSC	ICGC	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation altering degron motif	0.643
p.P532T	TCGA-97-A4M3	LUAD	TCGA	DSSQVYSSEP	CBL_PTK	523:532	Mutation altering degron motif	0.7031
p.P532T	DO218937	LUAD	ICGC	DSSQVYSSEP	CBL_PTK	523:532	Mutation altering degron motif	0.7031
p.E942K	TCGA-A5-A1OF	UCEC	TCGA	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation altering degron motif	0.7022
p.E942K	TCGA-B5-A11N	UCEC	TCGA	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation altering degron motif	0.7022
p.E942K	TCGA-EE-A2M5	SKCM	TCGA	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation altering degron motif	0.7022
p.E942K	TCGA-S9-A7IQ	LGG	TCGA	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation altering degron motif	0.7022
p.E942K	DO50204	LGG	ICGC	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation altering degron motif	0.7022
p.E942K	DO220903	MELA	ICGC	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation altering degron motif	0.7022
p.E942K	DO222423	MELA	ICGC	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation altering degron motif	0.7022
p.E942K	DO37425	SKCM	ICGC	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation altering degron motif	0.7022
p.E942K	DO42568	UCEC	ICGC	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation altering degron motif	0.7022
p.E942K	DO41458	UCEC	ICGC	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation altering degron motif	0.7022
p.A900E	TCGA-AP-A051	UCEC	TCGA	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation altering degron motif	0.7701
p.A900E	TCGA-AP-A051	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	900:904	Mutation altering degron motif	0.7701
p.A900E	DO42673	UCEC	ICGC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation altering degron motif	0.7701
p.A900E	DO42673	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	900:904	Mutation altering degron motif	0.7701
p.S902I	TCGA-AP-A059	UCEC	TCGA	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation altering degron motif	0.623
p.S902I	TCGA-AP-A059	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	900:904	Mutation altering degron motif	0.7341
p.S902I	DO41361	UCEC	ICGC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation altering degron motif	0.623
p.S902I	DO41361	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	900:904	Mutation altering degron motif	0.7341
p.S890L	TCGA-AP-A0LM	UCEC	TCGA	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation rewiring degron network	0.0833
p.S890L	TCGA-AP-A0LM	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.0556
p.S890L	TCGA-AX-A1CE	UCEC	TCGA	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation rewiring degron network	0.0833
p.S890L	TCGA-AX-A1CE	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.0556
p.S890L	DO222762	COCA	ICGC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation rewiring degron network	0.0833
p.S890L	DO222762	COCA	ICGC	APSSS	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.0556
p.S890L	DO43306	UCEC	ICGC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation rewiring degron network	0.0833
p.S890L	DO43306	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.0556
p.S890L	DO42280	UCEC	ICGC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation rewiring degron network	0.0833
p.S890L	DO42280	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.0556
p.S890L	SIDM00217	Colorectal Carcinoma	GDSC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation rewiring degron network	0.0833
p.S890L	SIDM00217	Colorectal Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.0556
p.S890L	ACH-000999	Colon/Colorectal Cancer	CCLE	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation rewiring degron network	0.0833
p.S890L	ACH-000999	Colon/Colorectal Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.0556
p.S890L	SNU-1040	large intestine	COSMIC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation rewiring degron network	0.0833
p.S890L	SNU-1040	large intestine	COSMIC	APSSS	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.0556
p.E916D	TCGA-AX-A1CE	UCEC	TCGA	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation rewiring degron network	0.1944
p.E916D	DO42280	UCEC	ICGC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation rewiring degron network	0.1944
p.V894G	TCGA-BR-4191	STAD	TCGA	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation rewiring degron network	0.1944
p.V894G	TCGA-BR-4191	STAD	TCGA	APSSS	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.1667
p.V894G	DO38891	STAD	ICGC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation rewiring degron network	0.1944
p.V894G	DO38891	STAD	ICGC	APSSS	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.1667
p.M933K	TCGA-D3-A1Q6	SKCM	TCGA	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation rewiring degron network	0.2222
p.M933K	DO37450	SKCM	ICGC	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation rewiring degron network	0.2222
p.M933I	TCGA-DK-A6B6	BLCA	TCGA	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation rewiring degron network	0.2222
p.M933I	TCGA-IH-A3EA	SKCM	TCGA	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation rewiring degron network	0.2222
p.M933I	DO48576	BLCA	ICGC	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation rewiring degron network	0.2222
p.M933I	DO37667	SKCM	ICGC	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation rewiring degron network	0.2222
p.P914S	TCGA-EE-A29C	SKCM	TCGA	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation rewiring degron network	0.25
p.P914S	TCGA-EE-A29C	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.0556
p.P914S	DO222727	MELA	ICGC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation rewiring degron network	0.25
p.P914S	DO222727	MELA	ICGC	APSSS	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.0556
p.P914S	DO38028	SKCM	ICGC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation rewiring degron network	0.25
p.P914S	DO38028	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.0556
p.H913Y	TCGA-EE-A29D	SKCM	TCGA	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation rewiring degron network	0.2778
p.H913Y	TCGA-EE-A29D	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.0833
p.H913Y	DO38123	SKCM	ICGC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation rewiring degron network	0.2778
p.H913Y	DO38123	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.0833
p.G535E	TCGA-EE-A3JI	SKCM	TCGA	DSSQVYSSEP	CBL_PTK	523:532	Mutation rewiring degron network	0.25
p.G535E	DO47268	SKCM	ICGC	DSSQVYSSEP	CBL_PTK	523:532	Mutation rewiring degron network	0.25
p.H947Y	TCGA-FW-A3R5	SKCM	TCGA	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation rewiring degron network	0.1944
p.H947Y	DO37406	SKCM	ICGC	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation rewiring degron network	0.1944
p.V527E	TCGA-MN-A4N5	LUAD	TCGA	DSSQVYSSEP	CBL_PTK	523:532	Mutation altering degron motif	0.6582
p.V527E	DO45332	LUAD	ICGC	DSSQVYSSEP	CBL_PTK	523:532	Mutation altering degron motif	0.6582
p.T522S	TCGA-NC-A5HJ	LUSC	TCGA	DSSQVYSSEP	CBL_PTK	523:532	Mutation rewiring degron network	0.3056
p.T522S	DO219189	LUSC	ICGC	DSSQVYSSEP	CBL_PTK	523:532	Mutation rewiring degron network	0.3056
p.I927N	TCGA-PK-A5HA	ACC	TCGA	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation rewiring degron network	0.0556
p.G533E	TCGA-UF-A719	HNSC	TCGA	DSSQVYSSEP	CBL_PTK	523:532	Mutation rewiring degron network	0.3056
p.G533E	DO52105	HNSC	ICGC	DSSQVYSSEP	CBL_PTK	523:532	Mutation rewiring degron network	0.3056
p.G533E	DO229446	SKCA	ICGC	DSSQVYSSEP	CBL_PTK	523:532	Mutation rewiring degron network	0.3056
p.K537R	DO48440	BLCA	ICGC	DSSQVYSSEP	CBL_PTK	523:532	Mutation substituting flanking lysine	0.3056
p.K537R	DO229005	COCA	ICGC	DSSQVYSSEP	CBL_PTK	523:532	Mutation substituting flanking lysine	0.3056
p.K537R	DO229346	LAML	ICGC	DSSQVYSSEP	CBL_PTK	523:532	Mutation substituting flanking lysine	0.3056
p.L909P	DO222769	COCA	ICGC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation altering degron motif	0.7582
p.D538N	DO229005	COCA	ICGC	DSSQVYSSEP	CBL_PTK	523:532	Mutation rewiring degron network	0.1667
p.D538N	DO229346	LAML	ICGC	DSSQVYSSEP	CBL_PTK	523:532	Mutation rewiring degron network	0.1667
p.Y528S	DO229005	COCA	ICGC	DSSQVYSSEP	CBL_PTK	523:532	Mutation altering degron motif	0.712
p.Y528S	DO229346	LAML	ICGC	DSSQVYSSEP	CBL_PTK	523:532	Mutation altering degron motif	0.712
p.Y528S	DO52365	LUSC	ICGC	DSSQVYSSEP	CBL_PTK	523:532	Mutation altering degron motif	0.712
p.V894A	DO234258	ESAD	ICGC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation rewiring degron network	0.1944
p.V894A	DO234258	ESAD	ICGC	APSSS	DEG_SPOP_SBC_1	900:904	Mutation rewiring degron network	0.1667
p.S518N	DO233882	GACA	ICGC	DSSQVYSSEP	CBL_PTK	523:532	Mutation rewiring degron network	0.1944
p.T910P	DO51004	LAML	ICGC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation altering degron motif	0.5919
p.E916V	DO228202	LICA	ICGC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation rewiring degron network	0.1944
p.D523Y	DO229015	LICA	ICGC	DSSQVYSSEP	CBL_PTK	523:532	Mutation altering degron motif	0.7325
p.E942D	DO229026	LICA	ICGC	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation altering degron motif	0.5647
p.T519P	DO220907	MELA	ICGC	DSSQVYSSEP	CBL_PTK	523:532	Mutation blocking phosphorylation signal	0.6667
p.T513S	SIDM01096	Colorectal Carcinoma	GDSC	DSSQVYSSEP	CBL_PTK	523:532	Mutation rewiring degron network	0.0556
p.T513S	ACH-000400	Colon/Colorectal Cancer	CCLE	DSSQVYSSEP	CBL_PTK	523:532	Mutation rewiring degron network	0.0556
p.T513S	SK-CO-1	large intestine	COSMIC	DSSQVYSSEP	CBL_PTK	523:532	Mutation rewiring degron network	0.0556
p.L539V	SIDM00234	Other Solid Cancers	GDSC	DSSQVYSSEP	CBL_PTK	523:532	Mutation rewiring degron network	0.1389
p.L539V	SIDM00315	Glioblastoma	GDSC	DSSQVYSSEP	CBL_PTK	523:532	Mutation rewiring degron network	0.1389
p.L539V	SIDM00530	Esophageal Carcinoma	GDSC	DSSQVYSSEP	CBL_PTK	523:532	Mutation rewiring degron network	0.1389
p.L539V	SIDM00351	Oral Cavity Carcinoma	GDSC	DSSQVYSSEP	CBL_PTK	523:532	Mutation rewiring degron network	0.1389
p.L539V	SIDM00251	Gastric Carcinoma	GDSC	DSSQVYSSEP	CBL_PTK	523:532	Mutation rewiring degron network	0.1389
p.L539V	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	DSSQVYSSEP	CBL_PTK	523:532	Mutation rewiring degron network	0.1389
p.L539V	SIDM00526	Chronic Myelogenous Leukemia	GDSC	DSSQVYSSEP	CBL_PTK	523:532	Mutation rewiring degron network	0.1389
p.L539V	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	DSSQVYSSEP	CBL_PTK	523:532	Mutation rewiring degron network	0.1389
p.L539V	SIDM01756	Chronic Myelogenous Leukemia	GDSC	DSSQVYSSEP	CBL_PTK	523:532	Mutation rewiring degron network	0.1389
p.L539V	SIDM01442	Glioma	GDSC	DSSQVYSSEP	CBL_PTK	523:532	Mutation rewiring degron network	0.1389
p.L539V	SIDM00497	Colorectal Carcinoma	GDSC	DSSQVYSSEP	CBL_PTK	523:532	Mutation rewiring degron network	0.1389
p.T930I	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation rewiring degron network	0.1389
p.T930I	ACH-000062	Lung Cancer	CCLE	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation rewiring degron network	0.1389
p.T930I	RERF-LC-MS	lung	COSMIC	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation rewiring degron network	0.1389
p.S902N	SIDM00151	Ovarian Carcinoma	GDSC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation altering degron motif	0.5958
p.S902N	SIDM00151	Ovarian Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	900:904	Mutation altering degron motif	0.7069
p.S902N	ACH-000966	Ovarian Cancer	CCLE	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation altering degron motif	0.5958
p.S902N	ACH-000966	Ovarian Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	900:904	Mutation altering degron motif	0.7069
p.S902N	IGROV-1	ovary	COSMIC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation altering degron motif	0.5958
p.S902N	IGROV-1	ovary	COSMIC	APSSS	DEG_SPOP_SBC_1	900:904	Mutation altering degron motif	0.7069
p.V921G	SIDM00516	Melanoma	GDSC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation rewiring degron network	0.0556
p.V921G	ACH-002166	Skin Cancer	CCLE	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation rewiring degron network	0.0556
p.V921G	MZ7-mel	skin	COSMIC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation rewiring degron network	0.0556
p.L943F	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation rewiring degron network	0.3056
p.L943F	ACH-000951	Lung Cancer	CCLE	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation rewiring degron network	0.3056
p.L943F	NCI-H2342	lung	COSMIC	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation rewiring degron network	0.3056
p.M933T	SIDM00655	Other Solid Cancers	GDSC	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation rewiring degron network	0.2222
p.M933T	ACH-001578	Embryonal Cancer	CCLE	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation rewiring degron network	0.2222
p.M933T	NCCIT	testis	COSMIC	LSMHPE	LIG_APCC_ABBA_1	937:942	Mutation rewiring degron network	0.2222
p.S525G	SIDM00699	Small Cell Lung Carcinoma	GDSC	DSSQVYSSEP	CBL_PTK	523:532	Mutation altering degron motif	0.5882
p.S525G	ACH-001138	Lung Cancer	CCLE	DSSQVYSSEP	CBL_PTK	523:532	Mutation altering degron motif	0.5882
p.S525G	NCI-H2141	lung	COSMIC	DSSQVYSSEP	CBL_PTK	523:532	Mutation altering degron motif	0.5882
p.A900T	SIDM01612	Endometrial Carcinoma	GDSC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation altering degron motif	0.7139
p.A900T	SIDM01612	Endometrial Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	900:904	Mutation altering degron motif	0.7139
p.A900T	ACH-000946	Endometrial/Uterine Cancer	CCLE	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation altering degron motif	0.7139
p.A900T	ACH-000946	Endometrial/Uterine Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	900:904	Mutation altering degron motif	0.7139
p.V921L	ACH-001367	Neuroblastoma	CCLE	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DSG1

UniProt ID: Q02413

Entrez ID: 1828

Protein name: Desmoglein-1 (Cadherin family member 4) (Desmosomal glycoprotein 1) (DG1) (DGI) (Pemphigus foliaceus antigen)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DSG1 in