DegronMD - Q02413(DSG1)

FUNCTION: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

GO - Biological processes (BP): calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell-cell adhesion [GO:0098609]; cell-cell junction assembly [GO:0007043]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; maternal process involved in female pregnancy [GO:00... View more >>

GO - Molecular function (MF): calcium ion binding [GO:0005509]; gamma-catenin binding [GO:0045295]; toxic substance binding [GO:0015643]

GO - Cellular component (CC): apical plasma membrane [GO:0016324]; cornified envelope [GO:0001533]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; desmosome [GO:0030057]; ficolin-1-rich granule membrane [GO:0101003]; integral component of membrane [GO:0016021]; lateral plasma membrane [GO:0016328]; plasm... View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A900E	TCGA-AP-A051	UCEC	TCGA	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation altering degron motif	0.7701
p.A900E	TCGA-AP-A051	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	900:904	Mutation altering degron motif	0.7701
p.A900E	DO42673	UCEC	ICGC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation altering degron motif	0.7701
p.A900E	DO42673	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	900:904	Mutation altering degron motif	0.7701
p.L909P	DO222769	COCA	ICGC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation altering degron motif	0.7582
p.S902I	TCGA-AP-A059	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	900:904	Mutation altering degron motif	0.7341
p.S902I	DO41361	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	900:904	Mutation altering degron motif	0.7341
p.D523Y	DO229015	LICA	ICGC	DSSQVYSSEP	CBL_PTK	523:532	Mutation altering degron motif	0.7325
p.A900T	SIDM01612	Endometrial Carcinoma	GDSC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation altering degron motif	0.7139
p.A900T	SIDM01612	Endometrial Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	900:904	Mutation altering degron motif	0.7139
p.A900T	ACH-000946	Endometrial/Uterine Cancer	CCLE	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	899:911	Mutation altering degron motif	0.7139
p.A900T	ACH-000946	Endometrial/Uterine Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	900:904	Mutation altering degron motif	0.7139
p.Y528S	DO229005	COCA	ICGC	DSSQVYSSEP	CBL_PTK	523:532	Mutation altering degron motif	0.712
p.Y528S	DO229346	LAML	ICGC	DSSQVYSSEP	CBL_PTK	523:532	Mutation altering degron motif	0.712
p.Y528S	DO52365	LUSC	ICGC	DSSQVYSSEP	CBL_PTK	523:532	Mutation altering degron motif	0.712
p.S902N	SIDM00151	Ovarian Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	900:904	Mutation altering degron motif	0.7069
p.S902N	ACH-000966	Ovarian Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	900:904	Mutation altering degron motif	0.7069
p.S902N	IGROV-1	ovary	COSMIC	APSSS	DEG_SPOP_SBC_1	900:904	Mutation altering degron motif	0.7069
p.P532T	TCGA-97-A4M3	LUAD	TCGA	DSSQVYSSEP	CBL_PTK	523:532	Mutation altering degron motif	0.7031
p.P532T	DO218937	LUAD	ICGC	DSSQVYSSEP	CBL_PTK	523:532	Mutation altering degron motif	0.7031

Showing 1 to 20 of 135 entries

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Kaplan plot for DSG1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DSG1

UniProt ID: Q02413

Entrez ID: 1828

Protein name: Desmoglein-1 (Cadherin family member 4) (Desmosomal glycoprotein 1) (DG1) (DGI) (Pemphigus foliaceus antigen)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DSG1 in