DegronMD

Uniprot ID: Q02413

Source protein: Desmoglein-1

Source gene: DSG1

Class: DEG_SPOP_SBC_1

Location: 900:904

E3 ligase: SPOP

DEGRON score: 0.9826

ASA_SCORE: 72.32

COIL: 0.8984

CONS_SCORE: 0.7323

DSS_SCORE: 0.3619

HELIX: 0.0164

FCONS_SCORE: 1.0668

RIG_SCORE: 0.6894

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A900E	TCGA-AP-A051	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	0.7701
p.A900E	DO42673	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	0.7701
p.S902I	TCGA-AP-A059	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	0.7341
p.S902I	DO41361	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	0.7341
p.A900T	SIDM01612	Endometrial Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	0.7139
p.A900T	ACH-000946	Endometrial/Uterine Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	0.7139
p.S902N	SIDM00151	Ovarian Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	0.7069
p.S902N	ACH-000966	Ovarian Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	0.7069
p.S902N	IGROV-1	ovary	COSMIC	APSSS	DEG_SPOP_SBC_1	0.7069
p.V894G	TCGA-BR-4191	STAD	TCGA	APSSS	DEG_SPOP_SBC_1	0.1667
p.V894G	DO38891	STAD	ICGC	APSSS	DEG_SPOP_SBC_1	0.1667
p.V894A	DO234258	ESAD	ICGC	APSSS	DEG_SPOP_SBC_1	0.1667
p.H913Y	TCGA-EE-A29D	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	0.0833
p.H913Y	DO38123	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	0.0833
p.S890L	TCGA-AP-A0LM	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	0.0556
p.S890L	TCGA-AX-A1CE	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	0.0556
p.S890L	DO222762	COCA	ICGC	APSSS	DEG_SPOP_SBC_1	0.0556
p.S890L	DO43306	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	0.0556
p.S890L	DO42280	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	0.0556
p.S890L	SIDM00217	Colorectal Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	0.0556
p.S890L	ACH-000999	Colon/Colorectal Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	0.0556
p.S890L	SNU-1040	large_intestine	COSMIC	APSSS	DEG_SPOP_SBC_1	0.0556
p.P914S	TCGA-EE-A29C	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	0.0556
p.P914S	DO222727	MELA	ICGC	APSSS	DEG_SPOP_SBC_1	0.0556
p.P914S	DO38028	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	0.0556

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Drug responses associated with DSG1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of APSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZ52	ADP-ribosylation factor-binding protein GGA3	DEG_SPOP_SBC_1	451:455	APSSS	SPOP	0.9988	More...
Q9UHB7	AF4/FMR2 family member 4	DEG_SPOP_SBC_1	882:886	APSSS	SPOP	0.9979	More...
Q6UB99	Ankyrin repeat domain-containing protein 11	DEG_SPOP_SBC_1	309:313	APSSS	SPOP	0.9971	More...
Q99490	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2	DEG_SPOP_SBC_1	136:140	APSSS	SPOP	0.9502	More...
Q8N1P7	Beta/gamma crystallin domain-containing protein 2	DEG_SPOP_SBC_1	707:711	APSSS	SPOP	0.9693	More...
Q5TH69	Brefeldin A-inhibited guanine nucleotide-exchange protein 3	DEG_SPOP_SBC_1	1647:1651	APSSS	SPOP	0.699	More...
A6NLJ0	C2 calcium-dependent domain-containing protein 4B	DEG_SPOP_SBC_1	221:225	APSSS	SPOP	0.9908	More...
Q14432	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	DEG_SPOP_SBC_1	471:475	APSSS	SPOP	0.9973	More...
O14646	Chromodomain-helicase-DNA-binding protein 1	DEG_SPOP_SBC_1	953:957	APSSS	SPOP	0.9988	More...
Q17RY0	Cytoplasmic polyadenylation element-binding protein 4	DEG_SPOP_SBC_1	176:180	APSSS	SPOP	0.6438	More...
P51813	Cytoplasmic tyrosine-protein kinase BMX	DEG_SPOP_SBC_1	184:188	APSSS	SPOP	0.948	More...
Q69YQ0	Cytospin-A	DEG_SPOP_SBC_1	365:369	APSSS	SPOP	0.9921	More...
Q96JK2	DDB1- and CUL4-associated factor 5	DEG_SPOP_SBC_1	703:707	APSSS	SPOP	0.9639	More...
Q9UER7	Death domain-associated protein 6	DEG_SPOP_SBC_1	38:42	APSSS	SPOP	0.9809	More...
Q9BTC0	Death-inducer obliterator 1	DEG_SPOP_SBC_1	971:975	APSSS	SPOP	0.8763	More...
Q02413	Desmoglein-1	DEG_SPOP_SBC_1	900:904	APSSS	SPOP	0.9826	More...
Q9Y253	DNA polymerase eta	DEG_SPOP_SBC_1	433:437	APSSS	SPOP	0.5241	More...
Q5F1R6	DnaJ homolog subfamily C member 21	DEG_SPOP_SBC_1	509:513	APSSS	SPOP	0.9898	More...
P22681	E3 ubiquitin-protein ligase CBL	DEG_SPOP_SBC_1	602:606	APSSS	SPOP	0.9967	More...
Q8IUD6	E3 ubiquitin-protein ligase RNF135	DEG_SPOP_SBC_1	232:236	APSSS	SPOP	0.9952	More...
Q5T4S7	E3 ubiquitin-protein ligase UBR4	DEG_SPOP_SBC_1	2847:2851	APSSS	SPOP	0.9198	More...
Q75VX8	GRB2-associated and regulator of MAPK protein 2	DEG_SPOP_SBC_1	684:688	APSSS	SPOP	0.9956	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	2812:2816	APSSS	SPOP	0.8312	More...
Q15111	Inactive phospholipase C-like protein 1	DEG_SPOP_SBC_1	1067:1071	APSSS	SPOP	0.9786	More...
Q96AC6	Kinesin-like protein KIFC2	DEG_SPOP_SBC_1	746:750	APSSS	SPOP	0.9977	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: APSSS

Degron related mutations and impact score

Drug responses associated with DSG1 mutations

All proteins holding degron of APSSS