DegronMD - P28749(RBL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q700L	TCGA-06-0155	GBM	TCGA	IAPSSSITAENVSI	DEG_ODPH_VHL_1	683:696	Mutation rewiring degron network	0.2222
p.Q700L	DO11292	GBM	ICGC	IAPSSSITAENVSI	DEG_ODPH_VHL_1	683:696	Mutation rewiring degron network	0.2222
p.A382S	TCGA-AP-A1DK	UCEC	TCGA	VITPVAS	DEG_SCF_FBW7_1	383:389	Mutation rewiring degron network	0.3056
p.A382S	DO42033	UCEC	ICGC	VITPVAS	DEG_SCF_FBW7_1	383:389	Mutation rewiring degron network	0.3056
p.L703I	TCGA-AP-A1DV	UCEC	TCGA	IAPSSSITAENVSI	DEG_ODPH_VHL_1	683:696	Mutation rewiring degron network	0.1389
p.L703I	DO229035	LICA	ICGC	IAPSSSITAENVSI	DEG_ODPH_VHL_1	683:696	Mutation rewiring degron network	0.1389
p.L703I	DO43186	UCEC	ICGC	IAPSSSITAENVSI	DEG_ODPH_VHL_1	683:696	Mutation rewiring degron network	0.1389
p.S688N	TCGA-AX-A1C5	UCEC	TCGA	IAPSSSITAENVSI	DEG_ODPH_VHL_1	683:696	Mutation altering degron motif	0.5958
p.S688N	TCGA-AX-A1C5	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	684:688	Mutation altering degron motif	0.7069
p.S688N	DO41422	UCEC	ICGC	IAPSSSITAENVSI	DEG_ODPH_VHL_1	683:696	Mutation altering degron motif	0.5958
p.S688N	DO41422	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	684:688	Mutation altering degron motif	0.7069
p.K682N	TCGA-AX-A2HC	UCEC	TCGA	IAPSSSITAENVSI	DEG_ODPH_VHL_1	683:696	Mutation rewiring degron network	0.3056
p.K682N	TCGA-AX-A2HC	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.2778
p.K682N	DO41572	UCEC	ICGC	IAPSSSITAENVSI	DEG_ODPH_VHL_1	683:696	Mutation rewiring degron network	0.3056
p.K682N	DO41572	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.2778
p.S650F	TCGA-AX-A2HC	UCEC	TCGA	KRRLFGE	LIG_APCC_ABBAyCdc20_2	657:663	Mutation blocking phosphorylation signal	0.5833
p.S650F	DO41572	UCEC	ICGC	KRRLFGE	LIG_APCC_ABBAyCdc20_2	657:663	Mutation blocking phosphorylation signal	0.5833
p.S650A	TCGA-AZ-4315	COAD	TCGA	KRRLFGE	LIG_APCC_ABBAyCdc20_2	657:663	Mutation blocking phosphorylation signal	0.5833
p.S650A	DO8842	COAD	ICGC	KRRLFGE	LIG_APCC_ABBAyCdc20_2	657:663	Mutation blocking phosphorylation signal	0.5833
p.A653T	TCGA-BR-4292	STAD	TCGA	KRRLFGE	LIG_APCC_ABBAyCdc20_2	657:663	Mutation rewiring degron network	0.2222
p.A653T	DO38495	STAD	ICGC	KRRLFGE	LIG_APCC_ABBAyCdc20_2	657:663	Mutation rewiring degron network	0.2222
p.Q398H	TCGA-DA-A1IB	SKCM	TCGA	VITPVAS	DEG_SCF_FBW7_1	383:389	Mutation rewiring degron network	0.0833
p.Q398H	DO38033	SKCM	ICGC	VITPVAS	DEG_SCF_FBW7_1	383:389	Mutation rewiring degron network	0.0833
p.R647C	TCGA-DF-A2KU	UCEC	TCGA	KRRLFGE	LIG_APCC_ABBAyCdc20_2	657:663	Mutation rewiring degron network	0.0556
p.R647C	DO223286	UCEC	ICGC	KRRLFGE	LIG_APCC_ABBAyCdc20_2	657:663	Mutation rewiring degron network	0.0556
p.Q392K	TCGA-ER-A19P	SKCM	TCGA	VITPVAS	DEG_SCF_FBW7_1	383:389	Mutation rewiring degron network	0.25
p.Q392K	DO228952	LICA	ICGC	VITPVAS	DEG_SCF_FBW7_1	383:389	Mutation rewiring degron network	0.25
p.Q392K	DO229027	LICA	ICGC	VITPVAS	DEG_SCF_FBW7_1	383:389	Mutation rewiring degron network	0.25
p.Q392K	DO47623	SKCM	ICGC	VITPVAS	DEG_SCF_FBW7_1	383:389	Mutation rewiring degron network	0.25
p.P685S	TCGA-FS-A1ZW	SKCM	TCGA	IAPSSSITAENVSI	DEG_ODPH_VHL_1	683:696	Mutation altering degron motif	0.6752
p.P685S	TCGA-FS-A1ZW	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	684:688	Mutation altering degron motif	0.5641
p.P685S	DO37519	SKCM	ICGC	IAPSSSITAENVSI	DEG_ODPH_VHL_1	683:696	Mutation altering degron motif	0.6752
p.P685S	DO37519	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	684:688	Mutation altering degron motif	0.5641
p.S389L	TCGA-JX-A3Q0	CESC	TCGA	VITPVAS	DEG_SCF_FBW7_1	383:389	Mutation altering degron motif	0.8778
p.S389L	DO51607	CESC	ICGC	VITPVAS	DEG_SCF_FBW7_1	383:389	Mutation altering degron motif	0.8778
p.Y376H	TCGA-L5-A8NM	ESCA	TCGA	VITPVAS	DEG_SCF_FBW7_1	383:389	Mutation rewiring degron network	0.1389
p.S695L	DO1116	BRCA	ICGC	IAPSSSITAENVSI	DEG_ODPH_VHL_1	683:696	Mutation altering degron motif	0.6556
p.S399T	DO6456	CLLE	ICGC	VITPVAS	DEG_SCF_FBW7_1	383:389	Mutation rewiring degron network	0.0556
p.P698H	DO229019	LICA	ICGC	IAPSSSITAENVSI	DEG_ODPH_VHL_1	683:696	Mutation rewiring degron network	0.2778
p.P698H	DO229019	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.0556
p.T704K	DO229025	LICA	ICGC	IAPSSSITAENVSI	DEG_ODPH_VHL_1	683:696	Mutation rewiring degron network	0.1111
p.Q398K	DO229027	LICA	ICGC	VITPVAS	DEG_SCF_FBW7_1	383:389	Mutation rewiring degron network	0.0833
p.A388E	DO229031	LICA	ICGC	VITPVAS	DEG_SCF_FBW7_1	383:389	Mutation altering degron motif	0.659
p.G678E	DO222887	MELA	ICGC	IAPSSSITAENVSI	DEG_ODPH_VHL_1	683:696	Mutation rewiring degron network	0.1944
p.G678E	DO222887	MELA	ICGC	APSSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.1667
p.P698L	DO33392	PACA	ICGC	IAPSSSITAENVSI	DEG_ODPH_VHL_1	683:696	Mutation rewiring degron network	0.2778
p.P698L	DO33392	PACA	ICGC	APSSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.0556
p.G662V	DO228016	SKCA	ICGC	KRRLFGE	LIG_APCC_ABBAyCdc20_2	657:663	Mutation altering degron motif	0.6421
p.A684T	SIDM00611	Kidney Carcinoma	GDSC	IAPSSSITAENVSI	DEG_ODPH_VHL_1	683:696	Mutation altering degron motif	0.7139
p.A684T	SIDM00611	Kidney Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	684:688	Mutation altering degron motif	0.7139
p.A684T	SIDM01659	Kidney Carcinoma	GDSC	IAPSSSITAENVSI	DEG_ODPH_VHL_1	683:696	Mutation altering degron motif	0.7139
p.A684T	SIDM01659	Kidney Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	684:688	Mutation altering degron motif	0.7139
p.A684T	ACH-000313	Kidney Cancer	CCLE	IAPSSSITAENVSI	DEG_ODPH_VHL_1	683:696	Mutation altering degron motif	0.7139
p.A684T	ACH-000313	Kidney Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	684:688	Mutation altering degron motif	0.7139
p.A684T	ACH-000684	Kidney Cancer	CCLE	IAPSSSITAENVSI	DEG_ODPH_VHL_1	683:696	Mutation altering degron motif	0.7139
p.A684T	ACH-000684	Kidney Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	684:688	Mutation altering degron motif	0.7139
p.A684T	KMRC-1	kidney	COSMIC	IAPSSSITAENVSI	DEG_ODPH_VHL_1	683:696	Mutation altering degron motif	0.7139
p.A684T	KMRC-1	kidney	COSMIC	APSSS	DEG_SPOP_SBC_1	684:688	Mutation altering degron motif	0.7139
p.S649C	SIDM00739	Non-Small Cell Lung Carcinoma	GDSC	KRRLFGE	LIG_APCC_ABBAyCdc20_2	657:663	Mutation rewiring degron network	0.1111
p.S649C	ACH-000675	Lung Cancer	CCLE	KRRLFGE	LIG_APCC_ABBAyCdc20_2	657:663	Mutation rewiring degron network	0.1111
p.S649C	NCI-H1734	lung	COSMIC	KRRLFGE	LIG_APCC_ABBAyCdc20_2	657:663	Mutation rewiring degron network	0.1111
p.R374W	SIDM00228	Thyroid Gland Carcinoma	GDSC	VITPVAS	DEG_SCF_FBW7_1	383:389	Mutation rewiring degron network	0.0833
p.R374W	ACH-000897	Thyroid Cancer	CCLE	VITPVAS	DEG_SCF_FBW7_1	383:389	Mutation rewiring degron network	0.0833
p.E677Q	ACH-000975	Lung Cancer	CCLE	IAPSSSITAENVSI	DEG_ODPH_VHL_1	683:696	Mutation rewiring degron network	0.1667
p.E677Q	ACH-000975	Lung Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.1389
p.G678R	ACH-001521	Skin Cancer	CCLE	IAPSSSITAENVSI	DEG_ODPH_VHL_1	683:696	Mutation rewiring degron network	0.1944
p.G678R	ACH-001521	Skin Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.1667
p.K682Q	ACH-001864	Bile Duct Cancer	CCLE	IAPSSSITAENVSI	DEG_ODPH_VHL_1	683:696	Mutation rewiring degron network	0.3056
p.K682Q	ACH-001864	Bile Duct Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	684:688	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RBL1

UniProt ID: P28749

Entrez ID: 5933

Protein name: Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RBL1 in