DegronMD

Uniprot ID: P28749

Source protein: Retinoblastoma-like protein 1

Source gene: RBL1

Class: LIG_APCC_ABBAyCdc20_2

Location: 657:663

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9635

ASA_SCORE: 99.1714

COIL: 0.6587

CONS_SCORE: 0.3063

DSS_SCORE: 0.615

HELIX: 0.2197

FCONS_SCORE: 1.0629

RIG_SCORE: 0.6917

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S650F	TCGA-AX-A2HC	UCEC	TCGA	KRRLFGE	LIG_APCC_ABBAyCdc20_2	0.5833
p.S650F	DO41572	UCEC	ICGC	KRRLFGE	LIG_APCC_ABBAyCdc20_2	0.5833
p.S650A	TCGA-AZ-4315	COAD	TCGA	KRRLFGE	LIG_APCC_ABBAyCdc20_2	0.5833
p.S650A	DO8842	COAD	ICGC	KRRLFGE	LIG_APCC_ABBAyCdc20_2	0.5833
p.A653T	TCGA-BR-4292	STAD	TCGA	KRRLFGE	LIG_APCC_ABBAyCdc20_2	0.2222
p.A653T	DO38495	STAD	ICGC	KRRLFGE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R647C	TCGA-DF-A2KU	UCEC	TCGA	KRRLFGE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R647C	DO223286	UCEC	ICGC	KRRLFGE	LIG_APCC_ABBAyCdc20_2	0.0556
p.G662V	DO228016	SKCA	ICGC	KRRLFGE	LIG_APCC_ABBAyCdc20_2	0.6421
p.S649C	SIDM00739	Non-Small Cell Lung Carcinoma	GDSC	KRRLFGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.S649C	ACH-000675	Lung Cancer	CCLE	KRRLFGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.S649C	NCI-H1734	lung	COSMIC	KRRLFGE	LIG_APCC_ABBAyCdc20_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28749	Retinoblastoma-like protein 1	LIG_APCC_ABBAyCdc20_2	657:663	KRRLFGE	APC,CDC20,FZR1	0.9635	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons