DegronMD

Uniprot ID: P28749

Source protein: Retinoblastoma-like protein 1

Source gene: RBL1

Class: DEG_ODPH_VHL_1

Location: 683:696

E3 ligase: VHL

DEGRON score: 0.9666

ASA_SCORE: 71.5786

COIL: 0.7374

CONS_SCORE: 0.2079

DSS_SCORE: 0.3293

HELIX: 0.1164

FCONS_SCORE: 0.9904

RIG_SCORE: 0.7647

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q700L	TCGA-06-0155	GBM	TCGA	IAPSSSITAENVSI	DEG_ODPH_VHL_1	0.2222
p.Q700L	DO11292	GBM	ICGC	IAPSSSITAENVSI	DEG_ODPH_VHL_1	0.2222
p.L703I	TCGA-AP-A1DV	UCEC	TCGA	IAPSSSITAENVSI	DEG_ODPH_VHL_1	0.1389
p.L703I	DO229035	LICA	ICGC	IAPSSSITAENVSI	DEG_ODPH_VHL_1	0.1389
p.L703I	DO43186	UCEC	ICGC	IAPSSSITAENVSI	DEG_ODPH_VHL_1	0.1389
p.S688N	TCGA-AX-A1C5	UCEC	TCGA	IAPSSSITAENVSI	DEG_ODPH_VHL_1	0.5958
p.S688N	DO41422	UCEC	ICGC	IAPSSSITAENVSI	DEG_ODPH_VHL_1	0.5958
p.K682N	TCGA-AX-A2HC	UCEC	TCGA	IAPSSSITAENVSI	DEG_ODPH_VHL_1	0.3056
p.K682N	DO41572	UCEC	ICGC	IAPSSSITAENVSI	DEG_ODPH_VHL_1	0.3056
p.P685S	TCGA-FS-A1ZW	SKCM	TCGA	IAPSSSITAENVSI	DEG_ODPH_VHL_1	0.6752
p.P685S	DO37519	SKCM	ICGC	IAPSSSITAENVSI	DEG_ODPH_VHL_1	0.6752
p.S695L	DO1116	BRCA	ICGC	IAPSSSITAENVSI	DEG_ODPH_VHL_1	0.6556
p.P698H	DO229019	LICA	ICGC	IAPSSSITAENVSI	DEG_ODPH_VHL_1	0.2778
p.T704K	DO229025	LICA	ICGC	IAPSSSITAENVSI	DEG_ODPH_VHL_1	0.1111
p.G678E	DO222887	MELA	ICGC	IAPSSSITAENVSI	DEG_ODPH_VHL_1	0.1944
p.P698L	DO33392	PACA	ICGC	IAPSSSITAENVSI	DEG_ODPH_VHL_1	0.2778
p.A684T	SIDM00611	Kidney Carcinoma	GDSC	IAPSSSITAENVSI	DEG_ODPH_VHL_1	0.7139
p.A684T	SIDM01659	Kidney Carcinoma	GDSC	IAPSSSITAENVSI	DEG_ODPH_VHL_1	0.7139
p.A684T	ACH-000313	Kidney Cancer	CCLE	IAPSSSITAENVSI	DEG_ODPH_VHL_1	0.7139
p.A684T	ACH-000684	Kidney Cancer	CCLE	IAPSSSITAENVSI	DEG_ODPH_VHL_1	0.7139
p.A684T	KMRC-1	kidney	COSMIC	IAPSSSITAENVSI	DEG_ODPH_VHL_1	0.7139
p.E677Q	ACH-000975	Lung Cancer	CCLE	IAPSSSITAENVSI	DEG_ODPH_VHL_1	0.1667
p.G678R	ACH-001521	Skin Cancer	CCLE	IAPSSSITAENVSI	DEG_ODPH_VHL_1	0.1944
p.K682Q	ACH-001864	Bile Duct Cancer	CCLE	IAPSSSITAENVSI	DEG_ODPH_VHL_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28749	Retinoblastoma-like protein 1	DEG_ODPH_VHL_1	683:696	IAPSSSITAENVSI	VHL	0.9666	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IAPSSSITAENVSI

Degron related mutations and impact score

Drug responses associated with RBL1 mutations

All proteins holding degron of IAPSSSITAENVSI