DegronMD

Uniprot ID: P28749

Source protein: Retinoblastoma-like protein 1

Source gene: RBL1

Class: DEG_SCF_FBW7_1

Location: 383:389

E3 ligase: FBXW7

DEGRON score: 0.9944

ASA_SCORE: 67.7143

COIL: 0.685

CONS_SCORE: 0.4712

DSS_SCORE: 0.3283

HELIX: 0.2639

FCONS_SCORE: 1.0722

RIG_SCORE: 0.7965

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A382S	TCGA-AP-A1DK	UCEC	TCGA	VITPVAS	DEG_SCF_FBW7_1	0.3056
p.A382S	DO42033	UCEC	ICGC	VITPVAS	DEG_SCF_FBW7_1	0.3056
p.Q398H	TCGA-DA-A1IB	SKCM	TCGA	VITPVAS	DEG_SCF_FBW7_1	0.0833
p.Q398H	DO38033	SKCM	ICGC	VITPVAS	DEG_SCF_FBW7_1	0.0833
p.Q392K	TCGA-ER-A19P	SKCM	TCGA	VITPVAS	DEG_SCF_FBW7_1	0.25
p.Q392K	DO228952	LICA	ICGC	VITPVAS	DEG_SCF_FBW7_1	0.25
p.Q392K	DO229027	LICA	ICGC	VITPVAS	DEG_SCF_FBW7_1	0.25
p.Q392K	DO47623	SKCM	ICGC	VITPVAS	DEG_SCF_FBW7_1	0.25
p.S389L	TCGA-JX-A3Q0	CESC	TCGA	VITPVAS	DEG_SCF_FBW7_1	0.8778
p.S389L	DO51607	CESC	ICGC	VITPVAS	DEG_SCF_FBW7_1	0.8778
p.Y376H	TCGA-L5-A8NM	ESCA	TCGA	VITPVAS	DEG_SCF_FBW7_1	0.1389
p.S399T	DO6456	CLLE	ICGC	VITPVAS	DEG_SCF_FBW7_1	0.0556
p.Q398K	DO229027	LICA	ICGC	VITPVAS	DEG_SCF_FBW7_1	0.0833
p.A388E	DO229031	LICA	ICGC	VITPVAS	DEG_SCF_FBW7_1	0.659
p.R374W	SIDM00228	Thyroid Gland Carcinoma	GDSC	VITPVAS	DEG_SCF_FBW7_1	0.0833
p.R374W	ACH-000897	Thyroid Cancer	CCLE	VITPVAS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P28749	Retinoblastoma-like protein 1	DEG_SCF_FBW7_1	383:389	VITPVAS	FBXW7	0.9944	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons