DegronMD - O94916(NFAT5)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E964D	TCGA-19-5956	GBM	TCGA	VATPGTT	DEG_SCF_FBW7_1	974:980	Mutation rewiring degron network	0.0556
p.E509D	TCGA-60-2698	LUSC	TCGA	VPPYHD	LIG_APCC_ABBA_1	508:513	Mutation altering degron motif	0.6758
p.A978V	TCGA-AX-A06F	UCEC	TCGA	VATPGTT	DEG_SCF_FBW7_1	974:980	Mutation altering degron motif	0.6936
p.T69I	TCGA-AX-A0J1	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.2778
p.T69I	DO41199	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.2778
p.H521Y	TCGA-CQ-7069	HNSC	TCGA	VPPYHD	LIG_APCC_ABBA_1	508:513	Mutation rewiring degron network	0.1111
p.P977S	TCGA-D3-A51G	SKCM	TCGA	VATPGTT	DEG_SCF_FBW7_1	974:980	Mutation altering degron motif	0.6752
p.P977S	TCGA-N7-A4Y0	UCS	TCGA	VATPGTT	DEG_SCF_FBW7_1	974:980	Mutation altering degron motif	0.6752
p.S505C	TCGA-D8-A1J8	BRCA	TCGA	VPPYHD	LIG_APCC_ABBA_1	508:513	Mutation rewiring degron network	0.25
p.S985F	TCGA-DK-A1AC	BLCA	TCGA	VATPGTT	DEG_SCF_FBW7_1	974:980	Mutation rewiring degron network	0.1944
p.F1200L	TCGA-DK-A6B6	BLCA	TCGA	IQTPMLS	DEG_SCF_FBW7_1	1191:1197	Mutation rewiring degron network	0.25
p.G71S	TCGA-EO-A22U	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	71:75	Mutation altering degron motif	0.6993
p.G71S	DO43755	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	71:75	Mutation altering degron motif	0.6993
p.V63L	DO222830	BTCA	ICGC	APSSS	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.1111
p.V82F	DO229036	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.1389
p.D77Y	DO229037	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.2778
p.A64S	DO229041	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.1389
p.D74Y	DO229008	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	71:75	Mutation altering degron motif	0.7325
p.P519A	DO231541	LINC	ICGC	VPPYHD	LIG_APCC_ABBA_1	508:513	Mutation rewiring degron network	0.1667
p.R62W	DO23516	LIRI	ICGC	APSSS	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.0833
p.D507G	DO25209	LUAD	ICGC	VPPYHD	LIG_APCC_ABBA_1	508:513	Mutation rewiring degron network	0.3056
p.S1205F	DO232224	PBCA	ICGC	IQTPMLS	DEG_SCF_FBW7_1	1191:1197	Mutation rewiring degron network	0.1111
p.P70L	DO37667	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.3056
p.P1206S	DO50301	SKCM	ICGC	IQTPMLS	DEG_SCF_FBW7_1	1191:1197	Mutation rewiring degron network	0.0833
p.N983I	DO38195	STAD	ICGC	VATPGTT	DEG_SCF_FBW7_1	974:980	Mutation rewiring degron network	0.25
p.K500R	DO50076	UCEC	ICGC	VPPYHD	LIG_APCC_ABBA_1	508:513	Mutation rewiring degron network	0.1111
p.N983H	DO43041	UCEC	ICGC	VATPGTT	DEG_SCF_FBW7_1	974:980	Mutation rewiring degron network	0.25
p.T502N	DO52402	UCEC	ICGC	VPPYHD	LIG_APCC_ABBA_1	508:513	Mutation rewiring degron network	0.1667
p.P1182Q	SIDM00845	Burkitt's Lymphoma	GDSC	IQTPMLS	DEG_SCF_FBW7_1	1191:1197	Mutation rewiring degron network	0.0833
p.Q969H	SIDM00419	Ewing's Sarcoma	GDSC	VATPGTT	DEG_SCF_FBW7_1	974:980	Mutation rewiring degron network	0.1944
p.S76L	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.3056
p.S76L	HOP-62	lung	COSMIC	APSSS	DEG_SPOP_SBC_1	71:75	Mutation rewiring degron network	0.3056
p.M966I	SIDM00217	Colorectal Carcinoma	GDSC	VATPGTT	DEG_SCF_FBW7_1	974:980	Mutation rewiring degron network	0.1111
p.M966I	SNU-1040	large intestine	COSMIC	VATPGTT	DEG_SCF_FBW7_1	974:980	Mutation rewiring degron network	0.1111
p.P976S	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	VATPGTT	DEG_SCF_FBW7_1	974:980	Mutation altering degron motif	0.6752
p.L985W	ACH-000449	Sarcoma	CCLE	VATPGTT	DEG_SCF_FBW7_1	974:980	Mutation rewiring degron network	0.1944
p.L985W	MES-SA	soft tissue	COSMIC	VATPGTT	DEG_SCF_FBW7_1	974:980	Mutation rewiring degron network	0.1944
p.Q1190R	ACH-000961	Endometrial/Uterine Cancer	CCLE	IQTPMLS	DEG_SCF_FBW7_1	1191:1197	Mutation rewiring degron network	0.3056
p.Q1184H	ACH-002256	Leukemia	CCLE	IQTPMLS	DEG_SCF_FBW7_1	1191:1197	Mutation rewiring degron network	0.1389
p.M965I	SNU-1040	large intestine	COSMIC	VATPGTT	DEG_SCF_FBW7_1	974:980	Mutation rewiring degron network	0.0833
p.Q1198H	PCI-15A	upper aerodigestive tract	COSMIC	IQTPMLS	DEG_SCF_FBW7_1	1191:1197	Mutation rewiring degron network	0.3056
p.V974I	LS-411N	large intestine	COSMIC	VATPGTT	DEG_SCF_FBW7_1	974:980	Mutation altering degron motif	0.5965
p.G1207S	JHU-022	upper aerodigestive tract	COSMIC	IQTPMLS	DEG_SCF_FBW7_1	1191:1197	Mutation rewiring degron network	0.0556

Kaplan plot for NFAT5 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NFAT5

UniProt ID: O94916

Entrez ID: 10725

Protein name: Nuclear factor of activated T-cells 5 (NF-AT5) (T-cell transcription factor NFAT5) (Tonicity-responsive enhancer-binding protein) (TonE-binding protein) (TonEBP)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for NFAT5 in