DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VATPGTT
Uniprot ID:
O94916
Source protein:
Nuclear factor of activated T-cells 5
Source gene:
NFAT5
Class:
DEG_SCF_FBW7_1
Location:
974:980
E3 ligase:
FBXW7
DEGRON score:
0.9786
ASA_SCORE:
91.3857
COIL:
0.9479
CONS_SCORE:
0.293
DSS_SCORE:
0.6544
HELIX:
0.0199
FCONS_SCORE:
0.9713
RIG_SCORE:
0.7029
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A978V
TCGA-AX-A06F
UCEC
TCGA
VATPGTT
DEG_SCF_FBW7_1
0.6936
p.P977S
TCGA-D3-A51G
SKCM
TCGA
VATPGTT
DEG_SCF_FBW7_1
0.6752
p.P977S
TCGA-N7-A4Y0
UCS
TCGA
VATPGTT
DEG_SCF_FBW7_1
0.6752
p.P976S
SIDM01510
Non-Small Cell Lung Carcinoma
GDSC
VATPGTT
DEG_SCF_FBW7_1
0.6752
p.V974I
LS-411N
large_intestine
COSMIC
VATPGTT
DEG_SCF_FBW7_1
0.5965
p.N983I
DO38195
STAD
ICGC
VATPGTT
DEG_SCF_FBW7_1
0.25
p.N983H
DO43041
UCEC
ICGC
VATPGTT
DEG_SCF_FBW7_1
0.25
p.S985F
TCGA-DK-A1AC
BLCA
TCGA
VATPGTT
DEG_SCF_FBW7_1
0.1944
p.Q969H
SIDM00419
Ewing's Sarcoma
GDSC
VATPGTT
DEG_SCF_FBW7_1
0.1944
p.L985W
ACH-000449
Sarcoma
CCLE
VATPGTT
DEG_SCF_FBW7_1
0.1944
p.L985W
MES-SA
soft_tissue
COSMIC
VATPGTT
DEG_SCF_FBW7_1
0.1944
p.M966I
SIDM00217
Colorectal Carcinoma
GDSC
VATPGTT
DEG_SCF_FBW7_1
0.1111
p.M966I
SNU-1040
large_intestine
COSMIC
VATPGTT
DEG_SCF_FBW7_1
0.1111
p.M965I
SNU-1040
large_intestine
COSMIC
VATPGTT
DEG_SCF_FBW7_1
0.0833
p.E964D
TCGA-19-5956
GBM
TCGA
VATPGTT
DEG_SCF_FBW7_1
0.0556
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Drug responses associated with NFAT5 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of VATPGTT
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O94916
Nuclear factor of activated T-cells 5
DEG_SCF_FBW7_1
974:980
VATPGTT
FBXW7
0.9786
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