DegronMD

Uniprot ID: O94916

Source protein: Nuclear factor of activated T-cells 5

Source gene: NFAT5

Class: DEG_SCF_FBW7_1

Location: 974:980

E3 ligase: FBXW7

DEGRON score: 0.9786

ASA_SCORE: 91.3857

COIL: 0.9479

CONS_SCORE: 0.293

DSS_SCORE: 0.6544

HELIX: 0.0199

FCONS_SCORE: 0.9713

RIG_SCORE: 0.7029

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E964D	TCGA-19-5956	GBM	TCGA	VATPGTT	DEG_SCF_FBW7_1	0.0556
p.A978V	TCGA-AX-A06F	UCEC	TCGA	VATPGTT	DEG_SCF_FBW7_1	0.6936
p.P977S	TCGA-D3-A51G	SKCM	TCGA	VATPGTT	DEG_SCF_FBW7_1	0.6752
p.P977S	TCGA-N7-A4Y0	UCS	TCGA	VATPGTT	DEG_SCF_FBW7_1	0.6752
p.S985F	TCGA-DK-A1AC	BLCA	TCGA	VATPGTT	DEG_SCF_FBW7_1	0.1944
p.N983I	DO38195	STAD	ICGC	VATPGTT	DEG_SCF_FBW7_1	0.25
p.N983H	DO43041	UCEC	ICGC	VATPGTT	DEG_SCF_FBW7_1	0.25
p.Q969H	SIDM00419	Ewing's Sarcoma	GDSC	VATPGTT	DEG_SCF_FBW7_1	0.1944
p.M966I	SIDM00217	Colorectal Carcinoma	GDSC	VATPGTT	DEG_SCF_FBW7_1	0.1111
p.M966I	SNU-1040	large_intestine	COSMIC	VATPGTT	DEG_SCF_FBW7_1	0.1111
p.P976S	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	VATPGTT	DEG_SCF_FBW7_1	0.6752
p.L985W	ACH-000449	Sarcoma	CCLE	VATPGTT	DEG_SCF_FBW7_1	0.1944
p.L985W	MES-SA	soft_tissue	COSMIC	VATPGTT	DEG_SCF_FBW7_1	0.1944
p.M965I	SNU-1040	large_intestine	COSMIC	VATPGTT	DEG_SCF_FBW7_1	0.0833
p.V974I	LS-411N	large_intestine	COSMIC	VATPGTT	DEG_SCF_FBW7_1	0.5965

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94916	Nuclear factor of activated T-cells 5	DEG_SCF_FBW7_1	974:980	VATPGTT	FBXW7	0.9786	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons