DegronMD

Uniprot ID: O94916

Source protein: Nuclear factor of activated T-cells 5

Source gene: NFAT5

Class: DEG_SCF_FBW7_1

Location: 1191:1197

E3 ligase: FBXW7

DEGRON score: 0.9735

ASA_SCORE: 107.8286

COIL: 0.9553

CONS_SCORE: 0.2957

DSS_SCORE: 0.7076

HELIX: 0.0271

FCONS_SCORE: 0.8746

RIG_SCORE: 0.6919

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F1200L	TCGA-DK-A6B6	BLCA	TCGA	IQTPMLS	DEG_SCF_FBW7_1	0.25
p.S1205F	DO232224	PBCA	ICGC	IQTPMLS	DEG_SCF_FBW7_1	0.1111
p.P1206S	DO50301	SKCM	ICGC	IQTPMLS	DEG_SCF_FBW7_1	0.0833
p.P1182Q	SIDM00845	Burkitt's Lymphoma	GDSC	IQTPMLS	DEG_SCF_FBW7_1	0.0833
p.Q1190R	ACH-000961	Endometrial/Uterine Cancer	CCLE	IQTPMLS	DEG_SCF_FBW7_1	0.3056
p.Q1184H	ACH-002256	Leukemia	CCLE	IQTPMLS	DEG_SCF_FBW7_1	0.1389
p.Q1198H	PCI-15A	upper_aerodigestive_tract	COSMIC	IQTPMLS	DEG_SCF_FBW7_1	0.3056
p.G1207S	JHU-022	upper_aerodigestive_tract	COSMIC	IQTPMLS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94916	Nuclear factor of activated T-cells 5	DEG_SCF_FBW7_1	1191:1197	IQTPMLS	FBXW7	0.9735	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons