DegronMD

Uniprot ID: O94916

Source protein: Nuclear factor of activated T-cells 5

Source gene: NFAT5

Class: LIG_APCC_ABBA_1

Location: 508:513

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5367

ASA_SCORE: 60.6167

COIL: 0.8402

CONS_SCORE: 0.7238

DSS_SCORE: 0.2026

HELIX: 0.0173

FCONS_SCORE: 1.2187

RIG_SCORE: 0.7667

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E509D	TCGA-60-2698	LUSC	TCGA	VPPYHD	LIG_APCC_ABBA_1	0.6758
p.H521Y	TCGA-CQ-7069	HNSC	TCGA	VPPYHD	LIG_APCC_ABBA_1	0.1111
p.S505C	TCGA-D8-A1J8	BRCA	TCGA	VPPYHD	LIG_APCC_ABBA_1	0.25
p.P519A	DO231541	LINC	ICGC	VPPYHD	LIG_APCC_ABBA_1	0.1667
p.D507G	DO25209	LUAD	ICGC	VPPYHD	LIG_APCC_ABBA_1	0.3056
p.K500R	DO50076	UCEC	ICGC	VPPYHD	LIG_APCC_ABBA_1	0.1111
p.T502N	DO52402	UCEC	ICGC	VPPYHD	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94916	Nuclear factor of activated T-cells 5	LIG_APCC_ABBA_1	508:513	VPPYHD	APC,CDC20,FZR1	0.5367	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons