DegronMD

Uniprot ID: Q9BZL4

Source protein: Protein phosphatase 1 regulatory subunit 12C

Source gene: PPP1R12C

Class: DEG_SPOP_SBC_1

Location: 334:338

E3 ligase: SPOP

DEGRON score: 0.5991

ASA_SCORE: 62.58

COIL: 0.7522

CONS_SCORE: 0.3873

DSS_SCORE: 0.7799

HELIX: 0.1782

FCONS_SCORE: 0.7939

RIG_SCORE: 0.4975

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S336Y	TCGA-22-5491	LUSC	TCGA	APSSS	DEG_SPOP_SBC_1	0.8231
p.S336Y	DO26420	LUSC	ICGC	APSSS	DEG_SPOP_SBC_1	0.8231
p.R328W	TCGA-55-7283	LUAD	TCGA	APSSS	DEG_SPOP_SBC_1	0.1667
p.R328W	DO23606	LUAD	ICGC	APSSS	DEG_SPOP_SBC_1	0.1667
p.A334V	TCGA-AA-3514	COAD	TCGA	APSSS	DEG_SPOP_SBC_1	0.5825
p.A334V	DO10486	COAD	ICGC	APSSS	DEG_SPOP_SBC_1	0.5825
p.S336F	TCGA-EE-A3JI	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	0.9093
p.S336F	DO47268	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	0.9093
p.S327N	SIDM00930	Osteosarcoma	GDSC	APSSS	DEG_SPOP_SBC_1	0.1389
p.S327N	ACH-001715	Bone Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	0.1389
p.S327N	CAL-72	bone	COSMIC	APSSS	DEG_SPOP_SBC_1	0.1389
p.P334S	MOLM-13	haematopoietic_and_lymphoid_tissue	COSMIC	APSSS	DEG_SPOP_SBC_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	731:735	APSSS	SPOP	0.9933	More...
O14646	Chromodomain-helicase-DNA-binding protein 1	DEG_SPOP_SBC_1	953:957	APSSS	SPOP	0.9988	More...
O15178	T-box transcription factor T	DEG_SPOP_SBC_1	392:396	APSSS	SPOP	0.9697	More...
O43151	Methylcytosine dioxygenase TET3	DEG_SPOP_SBC_1	494:498	APSSS	SPOP	0.9987	More...
O94916	Nuclear factor of activated T-cells 5	DEG_SPOP_SBC_1	71:75	APSSS	SPOP	0.9702	More...
P20333	Tumor necrosis factor receptor superfamily member 1B	DEG_SPOP_SBC_1	323:327	APSSS	SPOP	0.9828	More...
P22681	E3 ubiquitin-protein ligase CBL	DEG_SPOP_SBC_1	602:606	APSSS	SPOP	0.9967	More...
P28749	Retinoblastoma-like protein 1	DEG_SPOP_SBC_1	684:688	APSSS	SPOP	0.9678	More...
P49750	YLP motif-containing protein 1	DEG_SPOP_SBC_1	44:48	APSSS	SPOP	0.9709	More...
P51813	Cytoplasmic tyrosine-protein kinase BMX	DEG_SPOP_SBC_1	184:188	APSSS	SPOP	0.948	More...
P55055	Oxysterols receptor LXR-beta	DEG_SPOP_SBC_1	23:27	APSSS	SPOP	0.9793	More...
Q01538	Myelin transcription factor 1	DEG_SPOP_SBC_1	709:713	APSSS	SPOP	0.9547	More...
Q02413	Desmoglein-1	DEG_SPOP_SBC_1	900:904	APSSS	SPOP	0.9826	More...
Q12816	Trophinin	DEG_SPOP_SBC_1	744:748	APSSS	SPOP	0.7061	More...
Q13029	PR domain zinc finger protein 2	DEG_SPOP_SBC_1	997:1001	APSSS	SPOP	0.992	More...
Q14432	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	DEG_SPOP_SBC_1	471:475	APSSS	SPOP	0.9973	More...
Q15111	Inactive phospholipase C-like protein 1	DEG_SPOP_SBC_1	1067:1071	APSSS	SPOP	0.9786	More...
Q17RY0	Cytoplasmic polyadenylation element-binding protein 4	DEG_SPOP_SBC_1	176:180	APSSS	SPOP	0.6438	More...
Q5F1R6	DnaJ homolog subfamily C member 21	DEG_SPOP_SBC_1	509:513	APSSS	SPOP	0.9898	More...
Q5SRE5	Nucleoporin NUP188	DEG_SPOP_SBC_1	1528:1532	APSSS	SPOP	0.9644	More...
Q5T4S7	E3 ubiquitin-protein ligase UBR4	DEG_SPOP_SBC_1	2847:2851	APSSS	SPOP	0.9198	More...
Q5TH69	Brefeldin A-inhibited guanine nucleotide-exchange protein 3	DEG_SPOP_SBC_1	1647:1651	APSSS	SPOP	0.699	More...
Q69YQ0	Cytospin-A	DEG_SPOP_SBC_1	365:369	APSSS	SPOP	0.9921	More...
Q6DN14	Multiple C2 and transmembrane domain-containing protein 1	DEG_SPOP_SBC_1	156:160	APSSS	SPOP	0.97	More...
Q6UB99	Ankyrin repeat domain-containing protein 11	DEG_SPOP_SBC_1	309:313	APSSS	SPOP	0.9971	More...
Q6VN20	Ran-binding protein 10	DEG_SPOP_SBC_1	407:411	APSSS	SPOP	0.9973	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	2812:2816	APSSS	SPOP	0.8312	More...
Q765P7	Protein MTSS 2	DEG_SPOP_SBC_1	278:282	APSSS	SPOP	0.998	More...
Q86TC9	Myopalladin	DEG_SPOP_SBC_1	738:742	APSSS	SPOP	0.9648	More...
Q8IUD6	E3 ubiquitin-protein ligase RNF135	DEG_SPOP_SBC_1	232:236	APSSS	SPOP	0.9952	More...
Q8N1G1	RNA exonuclease 1 homolog	DEG_SPOP_SBC_1	579:583	APSSS	SPOP	0.9083	More...
Q8N568	Serine/threonine-protein kinase DCLK2	DEG_SPOP_SBC_1	27:31	APSSS	SPOP	0.9226	More...
Q8NFV4	Protein ABHD11	DEG_SPOP_SBC_1	37:41	APSSS	SPOP	0.9163	More...
Q92502	StAR-related lipid transfer protein 8	DEG_SPOP_SBC_1	98:102	APSSS	SPOP	0.9973	More...
Q92777	Synapsin-2	DEG_SPOP_SBC_1	510:514	APSSS	SPOP	0.9476	More...
Q92797	Symplekin	DEG_SPOP_SBC_1	1166:1170	APSSS	SPOP	0.9914	More...
Q96C03	Mitochondrial dynamics protein MID49	DEG_SPOP_SBC_1	97:101	APSSS	SPOP	0.9969	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	754:758	APSSS	SPOP	0.9874	More...
Q96IQ9	Zinc finger protein 414	DEG_SPOP_SBC_1	36:40	APSSS	SPOP	0.8854	More...
Q96JK2	DDB1- and CUL4-associated factor 5	DEG_SPOP_SBC_1	703:707	APSSS	SPOP	0.9639	More...
Q96RK0	Protein capicua homolog	DEG_SPOP_SBC_1	531:535	APSSS	SPOP	0.9615	More...
Q99490	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2	DEG_SPOP_SBC_1	136:140	APSSS	SPOP	0.9502	More...
Q9BTC0	Death-inducer obliterator 1	DEG_SPOP_SBC_1	971:975	APSSS	SPOP	0.8763	More...
Q9BZL4	Protein phosphatase 1 regulatory subunit 12C	DEG_SPOP_SBC_1	334:338	APSSS	SPOP	0.5991	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1546:1550	APSSS	SPOP	0.9917	More...
Q9H4Z2	Zinc finger protein 335	DEG_SPOP_SBC_1	391:395	APSSS	SPOP	0.9969	More...
Q9HCF6	Transient receptor potential cation channel subfamily M member 3	DEG_SPOP_SBC_1	1464:1468	APSSS	SPOP	0.826	More...
Q9NQB0	Transcription factor 7-like 2	DEG_SPOP_SBC_1	584:588	APSSS	SPOP	0.9803	More...
Q9NSC2	Sal-like protein 1	DEG_SPOP_SBC_1	148:152	APSSS	SPOP	0.9984	More...
Q9NVE5	Ubiquitin carboxyl-terminal hydrolase 40	DEG_SPOP_SBC_1	836:840	APSSS	SPOP	0.7326	More...
Q9NZ52	ADP-ribosylation factor-binding protein GGA3	DEG_SPOP_SBC_1	451:455	APSSS	SPOP	0.9988	More...
Q9P2Y4	Zinc finger protein 219	DEG_SPOP_SBC_1	157:161	APSSS	SPOP	0.9074	More...
Q9UER7	Death domain-associated protein 6	DEG_SPOP_SBC_1	38:42	APSSS	SPOP	0.9809	More...
Q9UGP4	LIM domain-containing protein 1	DEG_SPOP_SBC_1	349:353	APSSS	SPOP	0.9974	More...
Q9UHB7	AF4/FMR2 family member 4	DEG_SPOP_SBC_1	882:886	APSSS	SPOP	0.9979	More...
Q9UJ55	MAGE-like protein 2	DEG_SPOP_SBC_1	784:788	APSSS	SPOP	0.9907	More...
Q9UJQ4	Sal-like protein 4	DEG_SPOP_SBC_1	701:705	APSSS	SPOP	0.9907	More...
Q9UL68	Myelin transcription factor 1-like protein	DEG_SPOP_SBC_1	696:700	APSSS	SPOP	0.9933	More...
Q9UPN7	Serine/threonine-protein phosphatase 6 regulatory subunit 1	DEG_SPOP_SBC_1	814:818	APSSS	SPOP	0.9953	More...
Q9Y253	DNA polymerase eta	DEG_SPOP_SBC_1	433:437	APSSS	SPOP	0.5241	More...
Q9Y5B0	RNA polymerase II subunit A C-terminal domain phosphatase	DEG_SPOP_SBC_1	791:795	APSSS	SPOP	0.9729	More...
A6NLJ0	C2 calcium-dependent domain-containing protein 4B	DEG_SPOP_SBC_1	221:225	APSSS	SPOP	0.9908	More...
O14513	Nck-associated protein 5	DEG_SPOP_SBC_1	1024:1028	APSSS	SPOP	0.9788	More...
Q8WYQ9	Zinc finger CCHC domain-containing protein 14	DEG_SPOP_SBC_1	728:732	APSSS	SPOP	0.9933	More...
Q96AC6	Kinesin-like protein KIFC2	DEG_SPOP_SBC_1	746:750	APSSS	SPOP	0.9977	More...
Q9H2A3	Neurogenin-2	DEG_SPOP_SBC_1	221:225	APSSS	SPOP	0.7055	More...
Q75VX8	GRB2-associated and regulator of MAPK protein 2	DEG_SPOP_SBC_1	684:688	APSSS	SPOP	0.9956	More...
Q9HCE3	Zinc finger protein 532	DEG_SPOP_SBC_1	53:57	APSSS	SPOP	0.9702	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	338:342	APSSS	SPOP	0.9902	More...
Q8N1P7	Beta/gamma crystallin domain-containing protein 2	DEG_SPOP_SBC_1	707:711	APSSS	SPOP	0.9693	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: APSSS

Degron related mutations and impact score

Drug responses associated with PPP1R12C mutations

All proteins holding degron of APSSS