DegronMD - Q8N568(DCLK2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A334S	TCGA-12-0822	GBM	TCGA	LSTPKST	DEG_SCF_FBW7_1	329:335	Mutation altering degron motif	0.7588
p.A334S	DO11064	GBM	ICGC	LSTPKST	DEG_SCF_FBW7_1	329:335	Mutation altering degron motif	0.7588
p.R323Q	TCGA-A5-A2K3	UCEC	TCGA	LSTPKST	DEG_SCF_FBW7_1	329:335	Mutation rewiring degron network	0.1667
p.R323Q	DO43899	UCEC	ICGC	LSTPKST	DEG_SCF_FBW7_1	329:335	Mutation rewiring degron network	0.1667
p.G26W	TCGA-AA-3947	COAD	TCGA	APSSS	DEG_SPOP_SBC_1	27:31	Mutation rewiring degron network	0.3056
p.G26W	DO8192	COAD	ICGC	APSSS	DEG_SPOP_SBC_1	27:31	Mutation rewiring degron network	0.3056
p.G324S	TCGA-AP-A1DK	UCEC	TCGA	LSTPKST	DEG_SCF_FBW7_1	329:335	Mutation rewiring degron network	0.1944
p.G324S	DO42033	UCEC	ICGC	LSTPKST	DEG_SCF_FBW7_1	329:335	Mutation rewiring degron network	0.1944
p.R323W	TCGA-AX-A0J1	UCEC	TCGA	LSTPKST	DEG_SCF_FBW7_1	329:335	Mutation rewiring degron network	0.1667
p.R323W	DO41199	UCEC	ICGC	LSTPKST	DEG_SCF_FBW7_1	329:335	Mutation rewiring degron network	0.1667
p.S36G	TCGA-BR-8487	STAD	TCGA	APSSS	DEG_SPOP_SBC_1	27:31	Mutation rewiring degron network	0.1944
p.S36G	DO47867	STAD	ICGC	APSSS	DEG_SPOP_SBC_1	27:31	Mutation rewiring degron network	0.1944
p.S31P	TCGA-CR-7388	HNSC	TCGA	APSSS	DEG_SPOP_SBC_1	27:31	Mutation altering degron motif	0.7863
p.S31P	TCGA-FI-A2D5	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	27:31	Mutation altering degron motif	0.7863
p.S31P	DO14284	HNSC	ICGC	APSSS	DEG_SPOP_SBC_1	27:31	Mutation altering degron motif	0.7863
p.S31P	DO41331	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	27:31	Mutation altering degron motif	0.7863
p.S31P	ACH-001960	Bile Duct Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	27:31	Mutation altering degron motif	0.7863
p.K17N	TCGA-H7-A6C5	HNSC	TCGA	APSSS	DEG_SPOP_SBC_1	27:31	Mutation substituting flanking lysine	0.1667
p.K17N	DO49996	HNSC	ICGC	APSSS	DEG_SPOP_SBC_1	27:31	Mutation substituting flanking lysine	0.1667
p.R729S	TCGA-L5-A4OI	ESCA	TCGA	PAPTPPES	DEG_SCF_FBW7_1	736:743	Mutation rewiring degron network	0.1389
p.P734H	TCGA-QG-A5Z2	COAD	TCGA	PAPTPPES	DEG_SCF_FBW7_1	736:743	Mutation rewiring degron network	0.2778
p.S338C	DO458	BLCA	ICGC	LSTPKST	DEG_SCF_FBW7_1	329:335	Mutation blocking phosphorylation signal	0.6944
p.P332R	DO224995	BRCA	ICGC	LSTPKST	DEG_SCF_FBW7_1	329:335	Mutation altering degron motif	0.7512
p.P748S	DO229013	COCA	ICGC	PAPTPPES	DEG_SCF_FBW7_1	736:743	Mutation rewiring degron network	0.1944
p.P748S	DO229016	COCA	ICGC	PAPTPPES	DEG_SCF_FBW7_1	736:743	Mutation rewiring degron network	0.1944
p.P748S	DO229003	COCA	ICGC	PAPTPPES	DEG_SCF_FBW7_1	736:743	Mutation rewiring degron network	0.1944
p.P748S	DO229005	COCA	ICGC	PAPTPPES	DEG_SCF_FBW7_1	736:743	Mutation rewiring degron network	0.1944
p.P748R	DO229013	COCA	ICGC	PAPTPPES	DEG_SCF_FBW7_1	736:743	Mutation rewiring degron network	0.1944
p.P748R	DO229016	COCA	ICGC	PAPTPPES	DEG_SCF_FBW7_1	736:743	Mutation rewiring degron network	0.1944
p.P748R	DO229003	COCA	ICGC	PAPTPPES	DEG_SCF_FBW7_1	736:743	Mutation rewiring degron network	0.1944
p.P748R	DO229005	COCA	ICGC	PAPTPPES	DEG_SCF_FBW7_1	736:743	Mutation rewiring degron network	0.1944
p.S30F	DO233088	GACA	ICGC	APSSS	DEG_SPOP_SBC_1	27:31	Mutation altering degron motif	0.9093
p.P741L	DO233798	GACA	ICGC	PAPTPPES	DEG_SCF_FBW7_1	736:743	Mutation altering degron motif	0.6471
p.S339R	DO233823	GACA	ICGC	LSTPKST	DEG_SCF_FBW7_1	329:335	Mutation rewiring degron network	0.2222
p.P332S	DO219097	HNSC	ICGC	LSTPKST	DEG_SCF_FBW7_1	329:335	Mutation altering degron motif	0.6752
p.A27S	DO228971	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	27:31	Mutation altering degron motif	0.7588
p.A319S	DO229026	LICA	ICGC	LSTPKST	DEG_SCF_FBW7_1	329:335	Mutation rewiring degron network	0.0556
p.L329R	DO45201	LIRI	ICGC	LSTPKST	DEG_SCF_FBW7_1	329:335	Mutation altering degron motif	0.8428
p.S337F	DO37671	SKCM	ICGC	LSTPKST	DEG_SCF_FBW7_1	329:335	Mutation blocking phosphorylation signal	0.7222
p.P342Q	DO42033	UCEC	ICGC	LSTPKST	DEG_SCF_FBW7_1	329:335	Mutation rewiring degron network	0.1389
p.P746H	SIDM02021	Esophageal Carcinoma	GDSC	PAPTPPES	DEG_SCF_FBW7_1	736:743	Mutation rewiring degron network	0.25
p.P342L	SIDM00955	Melanoma	GDSC	LSTPKST	DEG_SCF_FBW7_1	329:335	Mutation rewiring degron network	0.1389
p.P342L	ACH-000812	Skin Cancer	CCLE	LSTPKST	DEG_SCF_FBW7_1	329:335	Mutation rewiring degron network	0.1389
p.P342L	COLO-783	skin	COSMIC	LSTPKST	DEG_SCF_FBW7_1	329:335	Mutation rewiring degron network	0.1389
p.P753S	SIDM00007	Other Solid Cancers	GDSC	PAPTPPES	DEG_SCF_FBW7_1	736:743	Mutation rewiring degron network	0.0556
p.P753S	ACH-001550	Skin Cancer	CCLE	PAPTPPES	DEG_SCF_FBW7_1	736:743	Mutation rewiring degron network	0.0556
p.P753S	MCC13	skin	COSMIC	PAPTPPES	DEG_SCF_FBW7_1	736:743	Mutation rewiring degron network	0.0556
p.G728S	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PAPTPPES	DEG_SCF_FBW7_1	736:743	Mutation rewiring degron network	0.1111
p.G728S	ACH-000937	Leukemia	CCLE	PAPTPPES	DEG_SCF_FBW7_1	736:743	Mutation rewiring degron network	0.1111
p.G728S	PF-382	haematopoietic and lymphoid tissue	COSMIC	PAPTPPES	DEG_SCF_FBW7_1	736:743	Mutation rewiring degron network	0.1111
p.R18K	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	27:31	Mutation rewiring degron network	0.0833
p.R18K	ACH-000851	Lung Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	27:31	Mutation rewiring degron network	0.0833
p.Y331C	SIDM01409	Bladder Carcinoma	GDSC	LSTPKST	DEG_SCF_FBW7_1	329:335	Mutation altering degron motif	0.7087
p.Y331C	ACH-000834	Bladder Cancer	CCLE	LSTPKST	DEG_SCF_FBW7_1	329:335	Mutation altering degron motif	0.7087
p.A27T	SIDM01424	B-Lymphoblastic Leukemia	GDSC	APSSS	DEG_SPOP_SBC_1	27:31	Mutation altering degron motif	0.7139
p.A27T	ACH-000782	Leukemia	CCLE	APSSS	DEG_SPOP_SBC_1	27:31	Mutation altering degron motif	0.7139
p.A27T	ACH-001735	Leukemia	CCLE	APSSS	DEG_SPOP_SBC_1	27:31	Mutation altering degron motif	0.7139
p.A737G	PC-14	lung	COSMIC	PAPTPPES	DEG_SCF_FBW7_1	736:743	Mutation altering degron motif	0.6429
p.S37P	SK-MG-1	central nervous system	COSMIC	APSSS	DEG_SPOP_SBC_1	27:31	Mutation rewiring degron network	0.1667
p.A736G	PC-14	lung	COSMIC	PAPTPPES	DEG_SCF_FBW7_1	736:743	Mutation altering degron motif	0.754
p.S334F	Mewo	skin	COSMIC	LSTPKST	DEG_SCF_FBW7_1	329:335	Mutation altering degron motif	0.6871
p.P735S	MCC13	skin	COSMIC	PAPTPPES	DEG_SCF_FBW7_1	736:743	Mutation rewiring degron network	0.3056
p.P325L	COLO-783	skin	COSMIC	LSTPKST	DEG_SCF_FBW7_1	329:335	Mutation rewiring degron network	0.2222
p.P736S	MCC13	skin	COSMIC	PAPTPPES	DEG_SCF_FBW7_1	736:743	Mutation altering degron motif	0.6752

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DCLK2

UniProt ID: Q8N568

Entrez ID: 166614

Protein name: Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (CaMK-like CREB regulatory kinase 2) (CL2) (CLICK-II) (CLICK2) (Doublecortin domain-containing protein 3B) (Doublecortin-like and CAM kinase-like 2) (Doublecortin-like kinase 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DCLK2 in