DegronMD

Uniprot ID: Q8N568

Source protein: Serine/threonine-protein kinase DCLK2

Source gene: DCLK2

Class: DEG_SCF_FBW7_1

Location: 736:743

E3 ligase: FBXW7

DEGRON score: 0.9959

ASA_SCORE: 102.2375

COIL: 0.9783

CONS_SCORE: 0.1391

DSS_SCORE: 0.7884

HELIX: 0.0079

FCONS_SCORE: 1.0978

RIG_SCORE: 0.4944

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A736G	PC-14	lung	COSMIC	PAPTPPES	DEG_SCF_FBW7_1	0.754
p.P736S	MCC13	skin	COSMIC	PAPTPPES	DEG_SCF_FBW7_1	0.6752
p.P741L	DO233798	GACA	ICGC	PAPTPPES	DEG_SCF_FBW7_1	0.6471
p.A737G	PC-14	lung	COSMIC	PAPTPPES	DEG_SCF_FBW7_1	0.6429
p.P735S	MCC13	skin	COSMIC	PAPTPPES	DEG_SCF_FBW7_1	0.3056
p.P734H	TCGA-QG-A5Z2	COAD	TCGA	PAPTPPES	DEG_SCF_FBW7_1	0.2778
p.P746H	SIDM02021	Esophageal Carcinoma	GDSC	PAPTPPES	DEG_SCF_FBW7_1	0.25
p.P748S	DO229013	COCA	ICGC	PAPTPPES	DEG_SCF_FBW7_1	0.1944
p.P748S	DO229016	COCA	ICGC	PAPTPPES	DEG_SCF_FBW7_1	0.1944
p.P748S	DO229003	COCA	ICGC	PAPTPPES	DEG_SCF_FBW7_1	0.1944
p.P748S	DO229005	COCA	ICGC	PAPTPPES	DEG_SCF_FBW7_1	0.1944
p.P748R	DO229013	COCA	ICGC	PAPTPPES	DEG_SCF_FBW7_1	0.1944
p.P748R	DO229016	COCA	ICGC	PAPTPPES	DEG_SCF_FBW7_1	0.1944
p.P748R	DO229003	COCA	ICGC	PAPTPPES	DEG_SCF_FBW7_1	0.1944
p.P748R	DO229005	COCA	ICGC	PAPTPPES	DEG_SCF_FBW7_1	0.1944
p.R729S	TCGA-L5-A4OI	ESCA	TCGA	PAPTPPES	DEG_SCF_FBW7_1	0.1389
p.G728S	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PAPTPPES	DEG_SCF_FBW7_1	0.1111
p.G728S	ACH-000937	Leukemia	CCLE	PAPTPPES	DEG_SCF_FBW7_1	0.1111
p.G728S	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	PAPTPPES	DEG_SCF_FBW7_1	0.1111
p.P753S	SIDM00007	Other Solid Cancers	GDSC	PAPTPPES	DEG_SCF_FBW7_1	0.0556
p.P753S	ACH-001550	Skin Cancer	CCLE	PAPTPPES	DEG_SCF_FBW7_1	0.0556
p.P753S	MCC13	skin	COSMIC	PAPTPPES	DEG_SCF_FBW7_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N568	Serine/threonine-protein kinase DCLK2	DEG_SCF_FBW7_1	736:743	PAPTPPES	FBXW7	0.9959	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons