DegronMD

Uniprot ID: Q8N568

Source protein: Serine/threonine-protein kinase DCLK2

Source gene: DCLK2

Class: DEG_SCF_FBW7_1

Location: 329:335

E3 ligase: FBXW7

DEGRON score: 0.9579

ASA_SCORE: 93.3429

COIL: 0.9263

CONS_SCORE: 0.4658

DSS_SCORE: 0.724

HELIX: 0.0387

FCONS_SCORE: 0.991

RIG_SCORE: 0.5542

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A334S	TCGA-12-0822	GBM	TCGA	LSTPKST	DEG_SCF_FBW7_1	0.7588
p.A334S	DO11064	GBM	ICGC	LSTPKST	DEG_SCF_FBW7_1	0.7588
p.R323Q	TCGA-A5-A2K3	UCEC	TCGA	LSTPKST	DEG_SCF_FBW7_1	0.1667
p.R323Q	DO43899	UCEC	ICGC	LSTPKST	DEG_SCF_FBW7_1	0.1667
p.G324S	TCGA-AP-A1DK	UCEC	TCGA	LSTPKST	DEG_SCF_FBW7_1	0.1944
p.G324S	DO42033	UCEC	ICGC	LSTPKST	DEG_SCF_FBW7_1	0.1944
p.R323W	TCGA-AX-A0J1	UCEC	TCGA	LSTPKST	DEG_SCF_FBW7_1	0.1667
p.R323W	DO41199	UCEC	ICGC	LSTPKST	DEG_SCF_FBW7_1	0.1667
p.S338C	DO458	BLCA	ICGC	LSTPKST	DEG_SCF_FBW7_1	0.6944
p.P332R	DO224995	BRCA	ICGC	LSTPKST	DEG_SCF_FBW7_1	0.7512
p.S339R	DO233823	GACA	ICGC	LSTPKST	DEG_SCF_FBW7_1	0.2222
p.P332S	DO219097	HNSC	ICGC	LSTPKST	DEG_SCF_FBW7_1	0.6752
p.A319S	DO229026	LICA	ICGC	LSTPKST	DEG_SCF_FBW7_1	0.0556
p.L329R	DO45201	LIRI	ICGC	LSTPKST	DEG_SCF_FBW7_1	0.8428
p.S337F	DO37671	SKCM	ICGC	LSTPKST	DEG_SCF_FBW7_1	0.7222
p.P342Q	DO42033	UCEC	ICGC	LSTPKST	DEG_SCF_FBW7_1	0.1389
p.P342L	SIDM00955	Melanoma	GDSC	LSTPKST	DEG_SCF_FBW7_1	0.1389
p.P342L	ACH-000812	Skin Cancer	CCLE	LSTPKST	DEG_SCF_FBW7_1	0.1389
p.P342L	COLO-783	skin	COSMIC	LSTPKST	DEG_SCF_FBW7_1	0.1389
p.Y331C	SIDM01409	Bladder Carcinoma	GDSC	LSTPKST	DEG_SCF_FBW7_1	0.7087
p.Y331C	ACH-000834	Bladder Cancer	CCLE	LSTPKST	DEG_SCF_FBW7_1	0.7087
p.S334F	Mewo	skin	COSMIC	LSTPKST	DEG_SCF_FBW7_1	0.6871
p.P325L	COLO-783	skin	COSMIC	LSTPKST	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N568	Serine/threonine-protein kinase DCLK2	DEG_SCF_FBW7_1	329:335	LSTPKST	FBXW7	0.9579	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons