DegronMD - Q9NZ52(GGA3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D333Y	TCGA-2G-AAFH	TGCT	TCGA	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	342:355	Mutation rewiring degron network	0.0833
p.Q361K	TCGA-66-2795	LUSC	TCGA	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	342:355	Mutation rewiring degron network	0.1667
p.Q361K	TCGA-66-2795	LUSC	TCGA	PAPTPPSS	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.0556
p.L338V	TCGA-AA-3984	COAD	TCGA	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	342:355	Mutation rewiring degron network	0.2222
p.L338V	TCGA-AA-3984	COAD	TCGA	PAPTPPSS	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.1667
p.T261S	TCGA-AJ-A3EK	UCEC	TCGA	KRRTLFKLA	DEG_APCC_DBOX_1	258:266	Mutation altering degron motif	0.6005
p.P162L	TCGA-AP-A1DK	UCEC	TCGA	KNPVFDD	LIG_APCC_ABBAyCdc20_2	165:171	Mutation rewiring degron network	0.25
p.G352D	TCGA-BR-8361	STAD	TCGA	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	342:355	Mutation altering degron motif	0.6087
p.K176E	TCGA-BR-A4QL	STAD	TCGA	KNPVFDD	LIG_APCC_ABBAyCdc20_2	165:171	Mutation blocking ubiquitination signal	0.6389
p.L156P	TCGA-CM-6162	COAD	TCGA	KNPVFDD	LIG_APCC_ABBAyCdc20_2	165:171	Mutation rewiring degron network	0.0833
p.S351L	TCGA-CR-6481	HNSC	TCGA	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	342:355	Mutation altering degron motif	0.6556
p.S351L	TCGA-CR-6481	HNSC	TCGA	PAPTPPSS	DEG_SCF_FBW7_1	344:351	Mutation altering degron motif	0.7667
p.P167S	TCGA-EB-A5UN	SKCM	TCGA	KNPVFDD	LIG_APCC_ABBAyCdc20_2	165:171	Mutation altering degron motif	0.5641
p.P167S	TCGA-GN-A8LK	SKCM	TCGA	KNPVFDD	LIG_APCC_ABBAyCdc20_2	165:171	Mutation altering degron motif	0.5641
p.S337T	TCGA-ER-A2NG	SKCM	TCGA	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	342:355	Mutation rewiring degron network	0.1944
p.S337T	TCGA-ER-A2NG	SKCM	TCGA	PAPTPPSS	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.1389
p.E172K	TCGA-FU-A40J	CESC	TCGA	KNPVFDD	LIG_APCC_ABBAyCdc20_2	165:171	Mutation rewiring degron network	0.3056
p.L156M	TCGA-IB-7651	PAAD	TCGA	KNPVFDD	LIG_APCC_ABBAyCdc20_2	165:171	Mutation rewiring degron network	0.0833
p.P160S	TCGA-OL-A66N	BRCA	TCGA	KNPVFDD	LIG_APCC_ABBAyCdc20_2	165:171	Mutation rewiring degron network	0.1944
p.D170H	TCGA-P4-A5EA	KIRP	TCGA	KNPVFDD	LIG_APCC_ABBAyCdc20_2	165:171	Mutation altering degron motif	0.6577
p.S371C	TCGA-Q1-A73O	CESC	TCGA	PSSTS	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.0833
p.S175C	TCGA-S5-AA26	BLCA	TCGA	KNPVFDD	LIG_APCC_ABBAyCdc20_2	165:171	Mutation rewiring degron network	0.2222
p.R255W	DO561	BLCA	ICGC	KRRTLFKLA	DEG_APCC_DBOX_1	258:266	Mutation rewiring degron network	0.25
p.R255W	DO38427	STAD	ICGC	KRRTLFKLA	DEG_APCC_DBOX_1	258:266	Mutation rewiring degron network	0.25
p.R255W	EB2	haematopoietic and lymphoid tissue	COSMIC	KRRTLFKLA	DEG_APCC_DBOX_1	258:266	Mutation rewiring degron network	0.25
p.S338C	DO51612	CESC	ICGC	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	342:355	Mutation rewiring degron network	0.2222
p.S338C	DO51612	CESC	ICGC	PAPTPPSS	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.1667
p.E272D	DO8778	COAD	ICGC	KRRTLFKLA	DEG_APCC_DBOX_1	258:266	Mutation rewiring degron network	0.1667
p.R255Q	DO8312	COAD	ICGC	KRRTLFKLA	DEG_APCC_DBOX_1	258:266	Mutation rewiring degron network	0.25
p.A379T	DO230311	COCA	ICGC	PSSTS	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.3056
p.S445N	DO222789	ESCA	ICGC	APSSS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.1667
p.E464Q	DO233204	GACA	ICGC	APSSS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.0833
p.L362I	DO228974	LICA	ICGC	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	342:355	Mutation rewiring degron network	0.1389
p.N381K	DO229036	LICA	ICGC	PSSTS	DEG_SPOP_SBC_1	380:384	Mutation altering degron motif	0.6918
p.A249D	DO229037	LICA	ICGC	KRRTLFKLA	DEG_APCC_DBOX_1	258:266	Mutation substituting flanking lysine	0.1944
p.P332T	DO229041	LICA	ICGC	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	342:355	Mutation rewiring degron network	0.0556
p.S349R	DO229009	LICA	ICGC	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	342:355	Mutation altering degron motif	0.7427
p.S349R	DO229009	LICA	ICGC	PAPTPPSS	DEG_SCF_FBW7_1	344:351	Mutation altering degron motif	0.7427
p.Q267K	DO229009	LICA	ICGC	KRRTLFKLA	DEG_APCC_DBOX_1	258:266	Mutation blocking phosphorylation signal	0.75
p.T453A	DO219178	LUSC	ICGC	APSSS	DEG_SPOP_SBC_1	451:455	Mutation altering degron motif	0.7139
p.L163V	DO52666	MALY	ICGC	KNPVFDD	LIG_APCC_ABBAyCdc20_2	165:171	Mutation rewiring degron network	0.2778
p.G380V	DO37679	SKCM	ICGC	PSSTS	DEG_SPOP_SBC_1	380:384	Mutation altering degron motif	0.7532
p.V256A	DO38795	STAD	ICGC	KRRTLFKLA	DEG_APCC_DBOX_1	258:266	Mutation rewiring degron network	0.2778
p.L459S	DO222392	STAD	ICGC	APSSS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.2222
p.R334Q	DO38288	STAD	ICGC	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	342:355	Mutation rewiring degron network	0.1111
p.R334Q	DO38288	STAD	ICGC	PAPTPPSS	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.0556
p.T275N	DO229264	THCA	ICGC	KRRTLFKLA	DEG_APCC_DBOX_1	258:266	Mutation blocking phosphorylation signal	0.5278
p.V373A	DO229218	THCA	ICGC	PSSTS	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.1389
p.A379V	DO229211	THCA	ICGC	PSSTS	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.3056
p.E272K	DO40843	UCEC	ICGC	KRRTLFKLA	DEG_APCC_DBOX_1	258:266	Mutation rewiring degron network	0.1667
p.R181H	DO41903	UCEC	ICGC	KNPVFDD	LIG_APCC_ABBAyCdc20_2	165:171	Mutation rewiring degron network	0.0556
p.R181H	DO41847	UCEC	ICGC	KNPVFDD	LIG_APCC_ABBAyCdc20_2	165:171	Mutation rewiring degron network	0.0556
p.R174W	DO42560	UCEC	ICGC	KNPVFDD	LIG_APCC_ABBAyCdc20_2	165:171	Mutation blocking ubiquitination signal	0.6944
p.R174W	DO42793	UCEC	ICGC	KNPVFDD	LIG_APCC_ABBAyCdc20_2	165:171	Mutation blocking ubiquitination signal	0.6944
p.V168M	DO41361	UCEC	ICGC	KNPVFDD	LIG_APCC_ABBAyCdc20_2	165:171	Mutation altering degron motif	0.6097
p.S371P	SIDM00396	Acute Myeloid Leukemia	GDSC	PSSTS	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.0833
p.S371P	SIG-M5	haematopoietic and lymphoid tissue	COSMIC	PSSTS	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.0833
p.A362D	SIDM00596	Endometrial Carcinoma	GDSC	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	342:355	Mutation rewiring degron network	0.1389
p.A362D	HEC-1	endometrium	COSMIC	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	342:355	Mutation rewiring degron network	0.1389
p.A345T	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	342:355	Mutation altering degron motif	0.6028
p.A345T	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	PAPTPPSS	DEG_SCF_FBW7_1	344:351	Mutation altering degron motif	0.6028
p.A345T	NCI-H1155	lung	COSMIC	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	342:355	Mutation altering degron motif	0.6028
p.A345T	NCI-H1155	lung	COSMIC	PAPTPPSS	DEG_SCF_FBW7_1	344:351	Mutation altering degron motif	0.6028
p.S371A	SIDM00404	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSSTS	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.0833
p.S371A	SU-DHL-16	haematopoietic and lymphoid tissue	COSMIC	PSSTS	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.0833
p.E270Q	SIDM00864	Cervical Carcinoma	GDSC	KRRTLFKLA	DEG_APCC_DBOX_1	258:266	Mutation rewiring degron network	0.2222
p.E270Q	DoTc2-4510	cervix	COSMIC	KRRTLFKLA	DEG_APCC_DBOX_1	258:266	Mutation rewiring degron network	0.2222
p.D333N	SIDM00850	Gastric Carcinoma	GDSC	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	342:355	Mutation rewiring degron network	0.0833
p.D333N	AGS	stomach	COSMIC	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	342:355	Mutation rewiring degron network	0.0833
p.K258N	SIDM01150	Non-Small Cell Lung Carcinoma	GDSC	KRRTLFKLA	DEG_APCC_DBOX_1	258:266	Mutation altering degron motif	0.5806
p.K258N	NCI-H838	lung	COSMIC	KRRTLFKLA	DEG_APCC_DBOX_1	258:266	Mutation altering degron motif	0.5806
p.D261N	ACH-000880	Gastric Cancer	CCLE	KRRTLFKLA	DEG_APCC_DBOX_1	258:266	Mutation altering degron motif	0.6932
p.D261N	AGS	stomach	COSMIC	KRRTLFKLA	DEG_APCC_DBOX_1	258:266	Mutation altering degron motif	0.6932
p.D170N	ACH-000960	Leukemia	CCLE	KNPVFDD	LIG_APCC_ABBAyCdc20_2	165:171	Mutation altering degron motif	0.5821
p.D170N	REH	haematopoietic and lymphoid tissue	COSMIC	KNPVFDD	LIG_APCC_ABBAyCdc20_2	165:171	Mutation altering degron motif	0.5821
p.A273T	ACH-000980	Lung Cancer	CCLE	KRRTLFKLA	DEG_APCC_DBOX_1	258:266	Mutation rewiring degron network	0.1389
p.A273T	NCI-H1155	lung	COSMIC	KRRTLFKLA	DEG_APCC_DBOX_1	258:266	Mutation rewiring degron network	0.1389
p.L444V	ACH-002349	Non-Cancerous	CCLE	APSSS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.1389
p.A377T	KP-N-YS	autonomic ganglia	COSMIC	PSSTS	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.25
p.R334W	SK-UT-1	soft tissue	COSMIC	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	342:355	Mutation rewiring degron network	0.1111
p.R334W	SK-UT-1	soft tissue	COSMIC	PAPTPPSS	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.0556
p.E259D	DG-75	haematopoietic and lymphoid tissue	COSMIC	KRRTLFKLA	DEG_APCC_DBOX_1	258:266	Mutation altering degron motif	0.6758
p.R173K	SF539	central nervous system	COSMIC	KNPVFDD	LIG_APCC_ABBAyCdc20_2	165:171	Mutation rewiring degron network	0.2778
p.S249A	SU-DHL-16	haematopoietic and lymphoid tissue	COSMIC	KRRTLFKLA	DEG_APCC_DBOX_1	258:266	Mutation substituting flanking lysine	0.1944
p.P452L	SNU-C2B	large intestine	COSMIC	APSSS	DEG_SPOP_SBC_1	451:455	Mutation altering degron motif	0.6471
p.P452L	HCC1143	breast	COSMIC	APSSS	DEG_SPOP_SBC_1	451:455	Mutation altering degron motif	0.6471
p.R166W	EB2	haematopoietic and lymphoid tissue	COSMIC	KNPVFDD	LIG_APCC_ABBAyCdc20_2	165:171	Mutation altering degron motif	0.8634
p.S338P	SIG-M5	haematopoietic and lymphoid tissue	COSMIC	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	342:355	Mutation rewiring degron network	0.2222
p.S338P	SIG-M5	haematopoietic and lymphoid tissue	COSMIC	PAPTPPSS	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.1667
p.S249P	SIG-M5	haematopoietic and lymphoid tissue	COSMIC	KRRTLFKLA	DEG_APCC_DBOX_1	258:266	Mutation substituting flanking lysine	0.1944
p.R181C	HCC1500	breast	COSMIC	KNPVFDD	LIG_APCC_ABBAyCdc20_2	165:171	Mutation rewiring degron network	0.0556
p.S338A	SU-DHL-16	haematopoietic and lymphoid tissue	COSMIC	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	342:355	Mutation rewiring degron network	0.2222
p.S338A	SU-DHL-16	haematopoietic and lymphoid tissue	COSMIC	PAPTPPSS	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GGA3

UniProt ID: Q9NZ52

Entrez ID: 23163

Protein name: ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GGA3 in