DegronMD

Uniprot ID: Q9NZ52

Source protein: ADP-ribosylation factor-binding protein GGA3

Source gene: GGA3

Class: DEG_APCC_DBOX_1

Location: 258:266

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8633

ASA_SCORE: 79.1222

COIL: 0.1867

CONS_SCORE: 0.4169

DSS_SCORE: 0.3729

HELIX: 0.807

FCONS_SCORE: 0.9891

RIG_SCORE: 0.8008

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T261S	TCGA-AJ-A3EK	UCEC	TCGA	KRRTLFKLA	DEG_APCC_DBOX_1	0.6005
p.R255W	DO561	BLCA	ICGC	KRRTLFKLA	DEG_APCC_DBOX_1	0.25
p.R255W	DO38427	STAD	ICGC	KRRTLFKLA	DEG_APCC_DBOX_1	0.25
p.R255W	EB2	haematopoietic_and_lymphoid_tissue	COSMIC	KRRTLFKLA	DEG_APCC_DBOX_1	0.25
p.E272D	DO8778	COAD	ICGC	KRRTLFKLA	DEG_APCC_DBOX_1	0.1667
p.R255Q	DO8312	COAD	ICGC	KRRTLFKLA	DEG_APCC_DBOX_1	0.25
p.A249D	DO229037	LICA	ICGC	KRRTLFKLA	DEG_APCC_DBOX_1	0.1944
p.Q267K	DO229009	LICA	ICGC	KRRTLFKLA	DEG_APCC_DBOX_1	0.75
p.V256A	DO38795	STAD	ICGC	KRRTLFKLA	DEG_APCC_DBOX_1	0.2778
p.T275N	DO229264	THCA	ICGC	KRRTLFKLA	DEG_APCC_DBOX_1	0.5278
p.E272K	DO40843	UCEC	ICGC	KRRTLFKLA	DEG_APCC_DBOX_1	0.1667
p.E270Q	SIDM00864	Cervical Carcinoma	GDSC	KRRTLFKLA	DEG_APCC_DBOX_1	0.2222
p.E270Q	DoTc2-4510	cervix	COSMIC	KRRTLFKLA	DEG_APCC_DBOX_1	0.2222
p.K258N	SIDM01150	Non-Small Cell Lung Carcinoma	GDSC	KRRTLFKLA	DEG_APCC_DBOX_1	0.5806
p.K258N	NCI-H838	lung	COSMIC	KRRTLFKLA	DEG_APCC_DBOX_1	0.5806
p.D261N	ACH-000880	Gastric Cancer	CCLE	KRRTLFKLA	DEG_APCC_DBOX_1	0.6932
p.D261N	AGS	stomach	COSMIC	KRRTLFKLA	DEG_APCC_DBOX_1	0.6932
p.A273T	ACH-000980	Lung Cancer	CCLE	KRRTLFKLA	DEG_APCC_DBOX_1	0.1389
p.A273T	NCI-H1155	lung	COSMIC	KRRTLFKLA	DEG_APCC_DBOX_1	0.1389
p.E259D	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	KRRTLFKLA	DEG_APCC_DBOX_1	0.6758
p.S249A	SU-DHL-16	haematopoietic_and_lymphoid_tissue	COSMIC	KRRTLFKLA	DEG_APCC_DBOX_1	0.1944
p.S249P	SIG-M5	haematopoietic_and_lymphoid_tissue	COSMIC	KRRTLFKLA	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZ52	ADP-ribosylation factor-binding protein GGA3	DEG_APCC_DBOX_1	258:266	KRRTLFKLA	APC,CDC20,FZR1	0.8633	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons