DegronMD

Uniprot ID: Q9NZ52

Source protein: ADP-ribosylation factor-binding protein GGA3

Source gene: GGA3

Class: DEG_ODPH_VHL_1

Location: 342:355

E3 ligase: VHL

DEGRON score: 0.969

ASA_SCORE: 83.9214

COIL: 0.9576

CONS_SCORE: 0.2645

DSS_SCORE: 0.6673

HELIX: 0.0201

FCONS_SCORE: 1.0115

RIG_SCORE: 0.5788

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D333Y	TCGA-2G-AAFH	TGCT	TCGA	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	0.0833
p.Q361K	TCGA-66-2795	LUSC	TCGA	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	0.1667
p.L338V	TCGA-AA-3984	COAD	TCGA	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	0.2222
p.G352D	TCGA-BR-8361	STAD	TCGA	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	0.6087
p.S351L	TCGA-CR-6481	HNSC	TCGA	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	0.6556
p.S337T	TCGA-ER-A2NG	SKCM	TCGA	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	0.1944
p.S338C	DO51612	CESC	ICGC	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	0.2222
p.L362I	DO228974	LICA	ICGC	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	0.1389
p.P332T	DO229041	LICA	ICGC	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	0.0556
p.S349R	DO229009	LICA	ICGC	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	0.7427
p.R334Q	DO38288	STAD	ICGC	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	0.1111
p.A362D	SIDM00596	Endometrial Carcinoma	GDSC	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	0.1389
p.A362D	HEC-1	endometrium	COSMIC	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	0.1389
p.A345T	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	0.6028
p.A345T	NCI-H1155	lung	COSMIC	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	0.6028
p.D333N	SIDM00850	Gastric Carcinoma	GDSC	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	0.0833
p.D333N	AGS	stomach	COSMIC	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	0.0833
p.R334W	SK-UT-1	soft_tissue	COSMIC	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	0.1111
p.S338P	SIG-M5	haematopoietic_and_lymphoid_tissue	COSMIC	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	0.2222
p.S338A	SU-DHL-16	haematopoietic_and_lymphoid_tissue	COSMIC	LAPAPTPPSSGIPI	DEG_ODPH_VHL_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZ52	ADP-ribosylation factor-binding protein GGA3	DEG_ODPH_VHL_1	342:355	LAPAPTPPSSGIPI	VHL	0.969	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons