DegronMD

Uniprot ID: Q9NZ52

Source protein: ADP-ribosylation factor-binding protein GGA3

Source gene: GGA3

Class: LIG_APCC_ABBAyCdc20_2

Location: 165:171

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9387

ASA_SCORE: 103.1

COIL: 0.91

CONS_SCORE: 0.4024

DSS_SCORE: 0.6898

HELIX: 0.0781

FCONS_SCORE: 0.9671

RIG_SCORE: 0.6697

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P162L	TCGA-AP-A1DK	UCEC	TCGA	KNPVFDD	LIG_APCC_ABBAyCdc20_2	0.25
p.K176E	TCGA-BR-A4QL	STAD	TCGA	KNPVFDD	LIG_APCC_ABBAyCdc20_2	0.6389
p.L156P	TCGA-CM-6162	COAD	TCGA	KNPVFDD	LIG_APCC_ABBAyCdc20_2	0.0833
p.P167S	TCGA-EB-A5UN	SKCM	TCGA	KNPVFDD	LIG_APCC_ABBAyCdc20_2	0.5641
p.P167S	TCGA-GN-A8LK	SKCM	TCGA	KNPVFDD	LIG_APCC_ABBAyCdc20_2	0.5641
p.E172K	TCGA-FU-A40J	CESC	TCGA	KNPVFDD	LIG_APCC_ABBAyCdc20_2	0.3056
p.L156M	TCGA-IB-7651	PAAD	TCGA	KNPVFDD	LIG_APCC_ABBAyCdc20_2	0.0833
p.P160S	TCGA-OL-A66N	BRCA	TCGA	KNPVFDD	LIG_APCC_ABBAyCdc20_2	0.1944
p.D170H	TCGA-P4-A5EA	KIRP	TCGA	KNPVFDD	LIG_APCC_ABBAyCdc20_2	0.6577
p.S175C	TCGA-S5-AA26	BLCA	TCGA	KNPVFDD	LIG_APCC_ABBAyCdc20_2	0.2222
p.L163V	DO52666	MALY	ICGC	KNPVFDD	LIG_APCC_ABBAyCdc20_2	0.2778
p.R181H	DO41903	UCEC	ICGC	KNPVFDD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R181H	DO41847	UCEC	ICGC	KNPVFDD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R174W	DO42560	UCEC	ICGC	KNPVFDD	LIG_APCC_ABBAyCdc20_2	0.6944
p.R174W	DO42793	UCEC	ICGC	KNPVFDD	LIG_APCC_ABBAyCdc20_2	0.6944
p.V168M	DO41361	UCEC	ICGC	KNPVFDD	LIG_APCC_ABBAyCdc20_2	0.6097
p.D170N	ACH-000960	Leukemia	CCLE	KNPVFDD	LIG_APCC_ABBAyCdc20_2	0.5821
p.D170N	REH	haematopoietic_and_lymphoid_tissue	COSMIC	KNPVFDD	LIG_APCC_ABBAyCdc20_2	0.5821
p.R173K	SF539	central_nervous_system	COSMIC	KNPVFDD	LIG_APCC_ABBAyCdc20_2	0.2778
p.R166W	EB2	haematopoietic_and_lymphoid_tissue	COSMIC	KNPVFDD	LIG_APCC_ABBAyCdc20_2	0.8634
p.R181C	HCC1500	breast	COSMIC	KNPVFDD	LIG_APCC_ABBAyCdc20_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZ52	ADP-ribosylation factor-binding protein GGA3	LIG_APCC_ABBAyCdc20_2	165:171	KNPVFDD	APC,CDC20,FZR1	0.9387	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons