DegronMD

Uniprot ID: Q9NZ52

Source protein: ADP-ribosylation factor-binding protein GGA3

Source gene: GGA3

Class: DEG_SCF_FBW7_1

Location: 344:351

E3 ligase: FBXW7

DEGRON score: 0.9977

ASA_SCORE: 86.825

COIL: 0.9609

CONS_SCORE: 0.284

DSS_SCORE: 0.6277

HELIX: 0.023

FCONS_SCORE: 1.1262

RIG_SCORE: 0.5597

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q361K	TCGA-66-2795	LUSC	TCGA	PAPTPPSS	DEG_SCF_FBW7_1	0.0556
p.L338V	TCGA-AA-3984	COAD	TCGA	PAPTPPSS	DEG_SCF_FBW7_1	0.1667
p.S351L	TCGA-CR-6481	HNSC	TCGA	PAPTPPSS	DEG_SCF_FBW7_1	0.7667
p.S337T	TCGA-ER-A2NG	SKCM	TCGA	PAPTPPSS	DEG_SCF_FBW7_1	0.1389
p.S338C	DO51612	CESC	ICGC	PAPTPPSS	DEG_SCF_FBW7_1	0.1667
p.S349R	DO229009	LICA	ICGC	PAPTPPSS	DEG_SCF_FBW7_1	0.7427
p.R334Q	DO38288	STAD	ICGC	PAPTPPSS	DEG_SCF_FBW7_1	0.0556
p.A345T	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	PAPTPPSS	DEG_SCF_FBW7_1	0.6028
p.A345T	NCI-H1155	lung	COSMIC	PAPTPPSS	DEG_SCF_FBW7_1	0.6028
p.R334W	SK-UT-1	soft_tissue	COSMIC	PAPTPPSS	DEG_SCF_FBW7_1	0.0556
p.S338P	SIG-M5	haematopoietic_and_lymphoid_tissue	COSMIC	PAPTPPSS	DEG_SCF_FBW7_1	0.1667
p.S338A	SU-DHL-16	haematopoietic_and_lymphoid_tissue	COSMIC	PAPTPPSS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZ52	ADP-ribosylation factor-binding protein GGA3	DEG_SCF_FBW7_1	344:351	PAPTPPSS	FBXW7	0.9977	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons