DegronMD - O43151(TET3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T811A	TCGA-5M-AAT6	COAD	TCGA	LDTPTKS	DEG_SCF_FBW7_1	806:812	Mutation altering degron motif	0.7139
p.T811A	DO223703	COAD	ICGC	LDTPTKS	DEG_SCF_FBW7_1	806:812	Mutation altering degron motif	0.7139
p.A415G	TCGA-A2-A0CL	BRCA	TCGA	PPATPRTE	DEG_SCF_FBW7_2	425:432	Mutation rewiring degron network	0.0556
p.A415G	DO2155	BRCA	ICGC	PPATPRTE	DEG_SCF_FBW7_2	425:432	Mutation rewiring degron network	0.0556
p.A784V	TCGA-A5-A0G1	UCEC	TCGA	PLTPTLS	DEG_SCF_FBW7_1	790:796	Mutation rewiring degron network	0.1667
p.A784V	DO42472	UCEC	ICGC	PLTPTLS	DEG_SCF_FBW7_1	790:796	Mutation rewiring degron network	0.1667
p.L1421M	TCGA-A5-A0G2	UCEC	TCGA	MGKTPLSE	DEG_SCF_FBW7_2	1417:1424	Mutation altering degron motif	0.711
p.L1421M	DO41235	UCEC	ICGC	MGKTPLSE	DEG_SCF_FBW7_2	1417:1424	Mutation altering degron motif	0.711
p.R798H	TCGA-AA-3864	COAD	TCGA	PLTPTLS	DEG_SCF_FBW7_1	790:796	Mutation rewiring degron network	0.2778
p.R798H	TCGA-AA-3864	COAD	TCGA	LDTPTKS	DEG_SCF_FBW7_1	806:812	Mutation rewiring degron network	0.1111
p.R798H	DO8490	COAD	ICGC	PLTPTLS	DEG_SCF_FBW7_1	790:796	Mutation rewiring degron network	0.2778
p.R798H	DO8490	COAD	ICGC	LDTPTKS	DEG_SCF_FBW7_1	806:812	Mutation rewiring degron network	0.1111
p.P512H	TCGA-AD-6889	COAD	TCGA	PTPSSE	DEG_SCF_FBW7_2	512:517	Mutation altering degron motif	0.7694
p.P512H	DO8463	COAD	ICGC	PTPSSE	DEG_SCF_FBW7_2	512:517	Mutation altering degron motif	0.7694
p.R490Q	TCGA-AJ-A3BG	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	494:498	Mutation rewiring degron network	0.2222
p.R490Q	DO42633	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	494:498	Mutation rewiring degron network	0.2222
p.S1409L	TCGA-AP-A0LM	UCEC	TCGA	MGKTPLSE	DEG_SCF_FBW7_2	1417:1424	Mutation rewiring degron network	0.1111
p.S1409L	DO43306	UCEC	ICGC	MGKTPLSE	DEG_SCF_FBW7_2	1417:1424	Mutation rewiring degron network	0.1111
p.R798C	TCGA-AX-A1CE	UCEC	TCGA	PLTPTLS	DEG_SCF_FBW7_1	790:796	Mutation rewiring degron network	0.2778
p.R798C	TCGA-AX-A1CE	UCEC	TCGA	LDTPTKS	DEG_SCF_FBW7_1	806:812	Mutation rewiring degron network	0.1111
p.R798C	DO42280	UCEC	ICGC	PLTPTLS	DEG_SCF_FBW7_1	790:796	Mutation rewiring degron network	0.2778
p.R798C	DO42280	UCEC	ICGC	LDTPTKS	DEG_SCF_FBW7_1	806:812	Mutation rewiring degron network	0.1111
p.P525L	TCGA-B6-A0RS	BRCA	TCGA	PTPSSE	DEG_SCF_FBW7_2	512:517	Mutation rewiring degron network	0.1111
p.P525L	TCGA-B6-A0RS	BRCA	TCGA	KRSLFLE	LIG_APCC_ABBAyCdc20_2	535:541	Mutation rewiring degron network	0.0556
p.P525L	DO4012	BRCA	ICGC	PTPSSE	DEG_SCF_FBW7_2	512:517	Mutation rewiring degron network	0.1111
p.P525L	DO4012	BRCA	ICGC	KRSLFLE	LIG_APCC_ABBAyCdc20_2	535:541	Mutation rewiring degron network	0.0556
p.P1424H	TCGA-D3-A2J8	SKCM	TCGA	MGKTPLSE	DEG_SCF_FBW7_2	1417:1424	Mutation altering degron motif	0.7694
p.P1424H	DO37778	SKCM	ICGC	MGKTPLSE	DEG_SCF_FBW7_2	1417:1424	Mutation altering degron motif	0.7694
p.P428Q	TCGA-D3-A2JD	SKCM	TCGA	PPATPRTE	DEG_SCF_FBW7_2	425:432	Mutation altering degron motif	0.7035
p.P428Q	DO37543	SKCM	ICGC	PPATPRTE	DEG_SCF_FBW7_2	425:432	Mutation altering degron motif	0.7035
p.S535I	TCGA-DF-A2KN	UCEC	TCGA	KRSLFLE	LIG_APCC_ABBAyCdc20_2	535:541	Mutation altering degron motif	0.7341
p.S535I	DO223282	UCEC	ICGC	KRSLFLE	LIG_APCC_ABBAyCdc20_2	535:541	Mutation altering degron motif	0.7341
p.P509S	TCGA-EE-A2MS	SKCM	TCGA	PTPSSE	DEG_SCF_FBW7_2	512:517	Mutation rewiring degron network	0.25
p.P509S	DO37567	SKCM	ICGC	PTPSSE	DEG_SCF_FBW7_2	512:517	Mutation rewiring degron network	0.25
p.R538S	TCGA-FV-A495	LIHC	TCGA	KRSLFLE	LIG_APCC_ABBAyCdc20_2	535:541	Mutation altering degron motif	0.7427
p.R538S	DO44890	LIHC	ICGC	KRSLFLE	LIG_APCC_ABBAyCdc20_2	535:541	Mutation altering degron motif	0.7427
p.K443M	TCGA-IB-7651	PAAD	TCGA	PPATPRSS	DEG_SCF_FBW7_1	442:449	Mutation altering degron motif	0.8062
p.K443M	DO46657	PAAD	ICGC	PPATPRSS	DEG_SCF_FBW7_1	442:449	Mutation altering degron motif	0.8062
p.A1434V	TCGA-L5-A43J	ESCA	TCGA	MGKTPLSE	DEG_SCF_FBW7_2	1417:1424	Mutation rewiring degron network	0.0556
p.E807K	TCGA-QC-A7B5	SARC	TCGA	LDTPTKS	DEG_SCF_FBW7_1	806:812	Mutation altering degron motif	0.7022
p.E807K	DO220239	SARC	ICGC	LDTPTKS	DEG_SCF_FBW7_1	806:812	Mutation altering degron motif	0.7022
p.A520D	TCGA-SJ-A6ZI	UCEC	TCGA	PTPSSE	DEG_SCF_FBW7_2	512:517	Mutation rewiring degron network	0.25
p.A520D	DO219784	UCEC	ICGC	PTPSSE	DEG_SCF_FBW7_2	512:517	Mutation rewiring degron network	0.25
p.K446Q	TCGA-V1-A9OQ	PRAD	TCGA	PPATPRSS	DEG_SCF_FBW7_1	442:449	Mutation altering degron motif	0.6944
p.K446Q	DO219383	PRAD	ICGC	PPATPRSS	DEG_SCF_FBW7_1	442:449	Mutation altering degron motif	0.6944
p.P448S	TCGA-Z2-A8RT	SKCM	TCGA	PPATPRSS	DEG_SCF_FBW7_1	442:449	Mutation altering degron motif	0.6752
p.P448S	DO51301	SKCM	ICGC	PPATPRSS	DEG_SCF_FBW7_1	442:449	Mutation altering degron motif	0.6752
p.R821W	DO222650	BTCA	ICGC	LDTPTKS	DEG_SCF_FBW7_1	806:812	Mutation rewiring degron network	0.0833
p.A421V	DO222950	BTCA	ICGC	PPATPRTE	DEG_SCF_FBW7_2	425:432	Mutation rewiring degron network	0.2222
p.A421V	DO23090	LINC	ICGC	PPATPRTE	DEG_SCF_FBW7_2	425:432	Mutation rewiring degron network	0.2222
p.A530P	DO230309	COCA	ICGC	KRSLFLE	LIG_APCC_ABBAyCdc20_2	535:541	Mutation rewiring degron network	0.1944
p.P450S	DO230309	COCA	ICGC	PPATPRSS	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.3056
p.P500S	DO222864	COCA	ICGC	APSSS	DEG_SPOP_SBC_1	494:498	Mutation rewiring degron network	0.2778
p.A784T	DO234374	ESAD	ICGC	PLTPTLS	DEG_SCF_FBW7_1	790:796	Mutation rewiring degron network	0.1667
p.R798L	DO228948	LICA	ICGC	PLTPTLS	DEG_SCF_FBW7_1	790:796	Mutation rewiring degron network	0.2778
p.R798L	DO228948	LICA	ICGC	LDTPTKS	DEG_SCF_FBW7_1	806:812	Mutation rewiring degron network	0.1111
p.V505L	DO229028	LICA	ICGC	PTPSSE	DEG_SCF_FBW7_2	512:517	Mutation rewiring degron network	0.1389
p.V505L	DO229028	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	494:498	Mutation rewiring degron network	0.1389
p.A792S	DO229041	LICA	ICGC	PLTPTLS	DEG_SCF_FBW7_1	790:796	Mutation altering degron motif	0.7588
p.D437E	DO229058	LICA	ICGC	PPATPRSS	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.1944
p.D437E	DO229058	LICA	ICGC	PPATPRTE	DEG_SCF_FBW7_2	425:432	Mutation rewiring degron network	0.1944
p.P797L	DO222714	MELA	ICGC	PLTPTLS	DEG_SCF_FBW7_1	790:796	Mutation rewiring degron network	0.3056
p.P797L	DO222714	MELA	ICGC	LDTPTKS	DEG_SCF_FBW7_1	806:812	Mutation rewiring degron network	0.0833
p.P509Q	DO232036	ORCA	ICGC	PTPSSE	DEG_SCF_FBW7_2	512:517	Mutation rewiring degron network	0.25
p.V432A	DO34656	PACA	ICGC	PPATPRTE	DEG_SCF_FBW7_2	425:432	Mutation altering degron motif	0.6936
p.P433S	DO228017	SKCA	ICGC	PPATPRSS	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.0833
p.P433S	DO228017	SKCA	ICGC	PPATPRTE	DEG_SCF_FBW7_2	425:432	Mutation rewiring degron network	0.3056
p.A1410V	DO229272	THCA	ICGC	MGKTPLSE	DEG_SCF_FBW7_2	1417:1424	Mutation rewiring degron network	0.1389
p.D545N	SIDM01266	Colorectal Carcinoma	GDSC	KRSLFLE	LIG_APCC_ABBAyCdc20_2	535:541	Mutation rewiring degron network	0.2222
p.T783S	SIDM00025	Head and Neck Carcinoma	GDSC	PLTPTLS	DEG_SCF_FBW7_1	790:796	Mutation rewiring degron network	0.1389
p.T783S	UDSCC2	upper aerodigestive tract	COSMIC	PLTPTLS	DEG_SCF_FBW7_1	790:796	Mutation rewiring degron network	0.1389
p.L507F	SIDM00007	Other Solid Cancers	GDSC	PTPSSE	DEG_SCF_FBW7_2	512:517	Mutation rewiring degron network	0.1944
p.L507F	SIDM00007	Other Solid Cancers	GDSC	APSSS	DEG_SPOP_SBC_1	494:498	Mutation rewiring degron network	0.0833
p.L507F	MCC13	skin	COSMIC	PTPSSE	DEG_SCF_FBW7_2	512:517	Mutation rewiring degron network	0.1944
p.L507F	MCC13	skin	COSMIC	APSSS	DEG_SPOP_SBC_1	494:498	Mutation rewiring degron network	0.0833
p.P459S	SIDM01240	Melanoma	GDSC	PPATPRSS	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.0556
p.P459S	451Lu	skin	COSMIC	PPATPRSS	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.0556
p.R454H	SIDM00917	Acute Myeloid Leukemia	GDSC	PPATPRSS	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.1944
p.R454H	CESS	haematopoietic and lymphoid tissue	COSMIC	PPATPRSS	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.1944
p.E1424D	SIDM00832	Colorectal Carcinoma	GDSC	MGKTPLSE	DEG_SCF_FBW7_2	1417:1424	Mutation altering degron motif	0.6758
p.E1424D	SW948	large intestine	COSMIC	MGKTPLSE	DEG_SCF_FBW7_2	1417:1424	Mutation altering degron motif	0.6758
p.T445M	SIDM01039	Other Solid Cancers	GDSC	PPATPRSS	DEG_SCF_FBW7_1	442:449	Mutation altering degron motif	0.8534
p.T445M	JAR	placenta	COSMIC	PPATPRSS	DEG_SCF_FBW7_1	442:449	Mutation altering degron motif	0.8534
p.E1424G	SIDM00282	Colorectal Carcinoma	GDSC	MGKTPLSE	DEG_SCF_FBW7_2	1417:1424	Mutation altering degron motif	0.7199
p.E1424G	CW-2	large intestine	COSMIC	MGKTPLSE	DEG_SCF_FBW7_2	1417:1424	Mutation altering degron motif	0.7199
p.R536H	SIDM01113	Other Sarcomas	GDSC	KRSLFLE	LIG_APCC_ABBAyCdc20_2	535:541	Mutation altering degron motif	0.7133
p.R536H	SK-UT-1	soft tissue	COSMIC	KRSLFLE	LIG_APCC_ABBAyCdc20_2	535:541	Mutation altering degron motif	0.7133
p.A427T	SIDM00214	Colorectal Carcinoma	GDSC	PPATPRTE	DEG_SCF_FBW7_2	425:432	Mutation altering degron motif	0.6028
p.A427T	SNU-407	large intestine	COSMIC	PPATPRTE	DEG_SCF_FBW7_2	425:432	Mutation altering degron motif	0.6028
p.V543G	SIDM01229	Neuroblastoma	GDSC	KRSLFLE	LIG_APCC_ABBAyCdc20_2	535:541	Mutation rewiring degron network	0.2778
p.V543G	BE2-M17	autonomic ganglia	COSMIC	KRSLFLE	LIG_APCC_ABBAyCdc20_2	535:541	Mutation rewiring degron network	0.2778
p.T546I	SIDM00256	Neuroblastoma	GDSC	KRSLFLE	LIG_APCC_ABBAyCdc20_2	535:541	Mutation rewiring degron network	0.1944
p.R447Q	SIDM01138	Pancreatic Carcinoma	GDSC	PPATPRSS	DEG_SCF_FBW7_1	442:449	Mutation altering degron motif	0.6218
p.R447Q	PANC-03-27	pancreas	COSMIC	PPATPRSS	DEG_SCF_FBW7_1	442:449	Mutation altering degron motif	0.6218
p.P425H	SIDM01491	Colorectal Carcinoma	GDSC	PPATPRTE	DEG_SCF_FBW7_2	425:432	Mutation altering degron motif	0.7694
p.P440T	ACH-000279	Bone Cancer	CCLE	PPATPRSS	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.2778
p.P440T	ACH-000279	Bone Cancer	CCLE	PPATPRTE	DEG_SCF_FBW7_2	425:432	Mutation rewiring degron network	0.1111
p.S528F	ACH-000509	Lymphoma	CCLE	KRSLFLE	LIG_APCC_ABBAyCdc20_2	535:541	Mutation rewiring degron network	0.1389
p.S528F	ACH-002240	Lymphoma	CCLE	KRSLFLE	LIG_APCC_ABBAyCdc20_2	535:541	Mutation rewiring degron network	0.1389
p.P524L	ACH-000574	Ovarian Cancer	CCLE	PTPSSE	DEG_SCF_FBW7_2	512:517	Mutation rewiring degron network	0.1389
p.H508Y	ACH-000581	Gastric Cancer	CCLE	PTPSSE	DEG_SCF_FBW7_2	512:517	Mutation rewiring degron network	0.2222
p.H508Y	ACH-000581	Gastric Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	494:498	Mutation rewiring degron network	0.0556
p.H508Y	ACH-001203	Lymphoma	CCLE	PTPSSE	DEG_SCF_FBW7_2	512:517	Mutation rewiring degron network	0.2222
p.H508Y	ACH-001203	Lymphoma	CCLE	APSSS	DEG_SPOP_SBC_1	494:498	Mutation rewiring degron network	0.0556
p.R538G	ACH-000786	Lymphoma	CCLE	KRSLFLE	LIG_APCC_ABBAyCdc20_2	535:541	Mutation altering degron motif	0.7568
p.R538M	ACH-000929	Lung Cancer	CCLE	KRSLFLE	LIG_APCC_ABBAyCdc20_2	535:541	Mutation altering degron motif	0.8632
p.G452R	ACH-000974	Endometrial/Uterine Cancer	CCLE	PPATPRSS	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.25
p.G801R	ACH-000988	Endometrial/Uterine Cancer	CCLE	PLTPTLS	DEG_SCF_FBW7_1	790:796	Mutation blocking phosphorylation signal	0.6389
p.G801R	ACH-000988	Endometrial/Uterine Cancer	CCLE	LDTPTKS	DEG_SCF_FBW7_1	806:812	Mutation blocking phosphorylation signal	0.6389
p.V521M	ACH-002044	Head and Neck Cancer	CCLE	PTPSSE	DEG_SCF_FBW7_2	512:517	Mutation rewiring degron network	0.2222
p.H550Y	NCI-SNU-16	stomach	COSMIC	KRSLFLE	LIG_APCC_ABBAyCdc20_2	535:541	Mutation rewiring degron network	0.0833
p.H550Y	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	KRSLFLE	LIG_APCC_ABBAyCdc20_2	535:541	Mutation rewiring degron network	0.0833
p.Q515H	NCI-H1573	lung	COSMIC	PTPSSE	DEG_SCF_FBW7_2	512:517	Mutation altering degron motif	0.7582
p.S792C	CAL-148	breast	COSMIC	PLTPTLS	DEG_SCF_FBW7_1	790:796	Mutation altering degron motif	0.7541
p.V510I	CW-2	large intestine	COSMIC	PTPSSE	DEG_SCF_FBW7_2	512:517	Mutation rewiring degron network	0.2778
p.R443H	SK-UT-1	soft tissue	COSMIC	PPATPRSS	DEG_SCF_FBW7_1	442:449	Mutation altering degron motif	0.8244
p.S1411P	NCI-H2081	lung	COSMIC	MGKTPLSE	DEG_SCF_FBW7_2	1417:1424	Mutation rewiring degron network	0.1667
p.S1411P	A101D	skin	COSMIC	MGKTPLSE	DEG_SCF_FBW7_2	1417:1424	Mutation rewiring degron network	0.1667
p.V450G	BE2-M17	autonomic ganglia	COSMIC	PPATPRSS	DEG_SCF_FBW7_1	442:449	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TET3

UniProt ID: O43151

Entrez ID: 200424

Protein name: Methylcytosine dioxygenase TET3 (EC 1.14.11.n2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TET3 in