DegronMD

Uniprot ID: O43151

Source protein: Methylcytosine dioxygenase TET3

Source gene: TET3

Class: DEG_SCF_FBW7_2

Location: 425:432

E3 ligase: FBXW7

DEGRON score: 0.9958

ASA_SCORE: 94.6125

COIL: 0.937

CONS_SCORE: 0.3823

DSS_SCORE: 0.6543

HELIX: 0.0306

FCONS_SCORE: 1.0671

RIG_SCORE: 0.6167

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A415G	TCGA-A2-A0CL	BRCA	TCGA	PPATPRTE	DEG_SCF_FBW7_2	0.0556
p.A415G	DO2155	BRCA	ICGC	PPATPRTE	DEG_SCF_FBW7_2	0.0556
p.P428Q	TCGA-D3-A2JD	SKCM	TCGA	PPATPRTE	DEG_SCF_FBW7_2	0.7035
p.P428Q	DO37543	SKCM	ICGC	PPATPRTE	DEG_SCF_FBW7_2	0.7035
p.A421V	DO222950	BTCA	ICGC	PPATPRTE	DEG_SCF_FBW7_2	0.2222
p.A421V	DO23090	LINC	ICGC	PPATPRTE	DEG_SCF_FBW7_2	0.2222
p.D437E	DO229058	LICA	ICGC	PPATPRTE	DEG_SCF_FBW7_2	0.1944
p.V432A	DO34656	PACA	ICGC	PPATPRTE	DEG_SCF_FBW7_2	0.6936
p.P433S	DO228017	SKCA	ICGC	PPATPRTE	DEG_SCF_FBW7_2	0.3056
p.A427T	SIDM00214	Colorectal Carcinoma	GDSC	PPATPRTE	DEG_SCF_FBW7_2	0.6028
p.A427T	SNU-407	large_intestine	COSMIC	PPATPRTE	DEG_SCF_FBW7_2	0.6028
p.P425H	SIDM01491	Colorectal Carcinoma	GDSC	PPATPRTE	DEG_SCF_FBW7_2	0.7694
p.P440T	ACH-000279	Bone Cancer	CCLE	PPATPRTE	DEG_SCF_FBW7_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43151	Methylcytosine dioxygenase TET3	DEG_SCF_FBW7_2	425:432	PPATPRTE	FBXW7	0.9958	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons