DegronMD

Uniprot ID: O43151

Source protein: Methylcytosine dioxygenase TET3

Source gene: TET3

Class: DEG_SCF_FBW7_1

Location: 442:449

E3 ligase: FBXW7

DEGRON score: 0.9574

ASA_SCORE: 94.6875

COIL: 0.9608

CONS_SCORE: 0.3273

DSS_SCORE: 0.7212

HELIX: 0.0208

FCONS_SCORE: 0.8909

RIG_SCORE: 0.5967

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K443M	TCGA-IB-7651	PAAD	TCGA	PPATPRSS	DEG_SCF_FBW7_1	0.8062
p.K443M	DO46657	PAAD	ICGC	PPATPRSS	DEG_SCF_FBW7_1	0.8062
p.K446Q	TCGA-V1-A9OQ	PRAD	TCGA	PPATPRSS	DEG_SCF_FBW7_1	0.6944
p.K446Q	DO219383	PRAD	ICGC	PPATPRSS	DEG_SCF_FBW7_1	0.6944
p.P448S	TCGA-Z2-A8RT	SKCM	TCGA	PPATPRSS	DEG_SCF_FBW7_1	0.6752
p.P448S	DO51301	SKCM	ICGC	PPATPRSS	DEG_SCF_FBW7_1	0.6752
p.P450S	DO230309	COCA	ICGC	PPATPRSS	DEG_SCF_FBW7_1	0.3056
p.D437E	DO229058	LICA	ICGC	PPATPRSS	DEG_SCF_FBW7_1	0.1944
p.P433S	DO228017	SKCA	ICGC	PPATPRSS	DEG_SCF_FBW7_1	0.0833
p.P459S	SIDM01240	Melanoma	GDSC	PPATPRSS	DEG_SCF_FBW7_1	0.0556
p.P459S	451Lu	skin	COSMIC	PPATPRSS	DEG_SCF_FBW7_1	0.0556
p.R454H	SIDM00917	Acute Myeloid Leukemia	GDSC	PPATPRSS	DEG_SCF_FBW7_1	0.1944
p.R454H	CESS	haematopoietic_and_lymphoid_tissue	COSMIC	PPATPRSS	DEG_SCF_FBW7_1	0.1944
p.T445M	SIDM01039	Other Solid Cancers	GDSC	PPATPRSS	DEG_SCF_FBW7_1	0.8534
p.T445M	JAR	placenta	COSMIC	PPATPRSS	DEG_SCF_FBW7_1	0.8534
p.R447Q	SIDM01138	Pancreatic Carcinoma	GDSC	PPATPRSS	DEG_SCF_FBW7_1	0.6218
p.R447Q	PANC-03-27	pancreas	COSMIC	PPATPRSS	DEG_SCF_FBW7_1	0.6218
p.P440T	ACH-000279	Bone Cancer	CCLE	PPATPRSS	DEG_SCF_FBW7_1	0.2778
p.G452R	ACH-000974	Endometrial/Uterine Cancer	CCLE	PPATPRSS	DEG_SCF_FBW7_1	0.25
p.R443H	SK-UT-1	soft_tissue	COSMIC	PPATPRSS	DEG_SCF_FBW7_1	0.8244
p.V450G	BE2-M17	autonomic_ganglia	COSMIC	PPATPRSS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43151	Methylcytosine dioxygenase TET3	DEG_SCF_FBW7_1	442:449	PPATPRSS	FBXW7	0.9574	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons