DegronMD

Uniprot ID: O43151

Source protein: Methylcytosine dioxygenase TET3

Source gene: TET3

Class: DEG_SCF_FBW7_2

Location: 512:517

E3 ligase: FBXW7

DEGRON score: 0.9869

ASA_SCORE: 98.8167

COIL: 0.9568

CONS_SCORE: 0.3462

DSS_SCORE: 0.8528

HELIX: 0.0332

FCONS_SCORE: 1.0148

RIG_SCORE: 0.4984

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P512H	TCGA-AD-6889	COAD	TCGA	PTPSSE	DEG_SCF_FBW7_2	0.7694
p.P512H	DO8463	COAD	ICGC	PTPSSE	DEG_SCF_FBW7_2	0.7694
p.P525L	TCGA-B6-A0RS	BRCA	TCGA	PTPSSE	DEG_SCF_FBW7_2	0.1111
p.P525L	DO4012	BRCA	ICGC	PTPSSE	DEG_SCF_FBW7_2	0.1111
p.P509S	TCGA-EE-A2MS	SKCM	TCGA	PTPSSE	DEG_SCF_FBW7_2	0.25
p.P509S	DO37567	SKCM	ICGC	PTPSSE	DEG_SCF_FBW7_2	0.25
p.A520D	TCGA-SJ-A6ZI	UCEC	TCGA	PTPSSE	DEG_SCF_FBW7_2	0.25
p.A520D	DO219784	UCEC	ICGC	PTPSSE	DEG_SCF_FBW7_2	0.25
p.V505L	DO229028	LICA	ICGC	PTPSSE	DEG_SCF_FBW7_2	0.1389
p.P509Q	DO232036	ORCA	ICGC	PTPSSE	DEG_SCF_FBW7_2	0.25
p.L507F	SIDM00007	Other Solid Cancers	GDSC	PTPSSE	DEG_SCF_FBW7_2	0.1944
p.L507F	MCC13	skin	COSMIC	PTPSSE	DEG_SCF_FBW7_2	0.1944
p.P524L	ACH-000574	Ovarian Cancer	CCLE	PTPSSE	DEG_SCF_FBW7_2	0.1389
p.H508Y	ACH-000581	Gastric Cancer	CCLE	PTPSSE	DEG_SCF_FBW7_2	0.2222
p.H508Y	ACH-001203	Lymphoma	CCLE	PTPSSE	DEG_SCF_FBW7_2	0.2222
p.V521M	ACH-002044	Head and Neck Cancer	CCLE	PTPSSE	DEG_SCF_FBW7_2	0.2222
p.Q515H	NCI-H1573	lung	COSMIC	PTPSSE	DEG_SCF_FBW7_2	0.7582
p.V510I	CW-2	large_intestine	COSMIC	PTPSSE	DEG_SCF_FBW7_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43151	Methylcytosine dioxygenase TET3	DEG_SCF_FBW7_2	512:517	PTPSSE	FBXW7	0.9869	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons