DegronMD

Uniprot ID: O43151

Source protein: Methylcytosine dioxygenase TET3

Source gene: TET3

Class: DEG_SCF_FBW7_1

Location: 806:812

E3 ligase: FBXW7

DEGRON score: 0.9667

ASA_SCORE: 72.2286

COIL: 0.6743

CONS_SCORE: 0.4905

DSS_SCORE: 0.4506

HELIX: 0.2961

FCONS_SCORE: 0.7835

RIG_SCORE: 0.7653

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T811A	TCGA-5M-AAT6	COAD	TCGA	LDTPTKS	DEG_SCF_FBW7_1	0.7139
p.T811A	DO223703	COAD	ICGC	LDTPTKS	DEG_SCF_FBW7_1	0.7139
p.R798H	TCGA-AA-3864	COAD	TCGA	LDTPTKS	DEG_SCF_FBW7_1	0.1111
p.R798H	DO8490	COAD	ICGC	LDTPTKS	DEG_SCF_FBW7_1	0.1111
p.R798C	TCGA-AX-A1CE	UCEC	TCGA	LDTPTKS	DEG_SCF_FBW7_1	0.1111
p.R798C	DO42280	UCEC	ICGC	LDTPTKS	DEG_SCF_FBW7_1	0.1111
p.E807K	TCGA-QC-A7B5	SARC	TCGA	LDTPTKS	DEG_SCF_FBW7_1	0.7022
p.E807K	DO220239	SARC	ICGC	LDTPTKS	DEG_SCF_FBW7_1	0.7022
p.R821W	DO222650	BTCA	ICGC	LDTPTKS	DEG_SCF_FBW7_1	0.0833
p.R798L	DO228948	LICA	ICGC	LDTPTKS	DEG_SCF_FBW7_1	0.1111
p.P797L	DO222714	MELA	ICGC	LDTPTKS	DEG_SCF_FBW7_1	0.0833
p.G801R	ACH-000988	Endometrial/Uterine Cancer	CCLE	LDTPTKS	DEG_SCF_FBW7_1	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43151	Methylcytosine dioxygenase TET3	DEG_SCF_FBW7_1	806:812	LDTPTKS	FBXW7	0.9667	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons