DegronMD

Uniprot ID: O43151

Source protein: Methylcytosine dioxygenase TET3

Source gene: TET3

Class: DEG_SCF_FBW7_1

Location: 790:796

E3 ligase: FBXW7

DEGRON score: 0.9994

ASA_SCORE: 87.2286

COIL: 0.9311

CONS_SCORE: 0.7603

DSS_SCORE: 0.5579

HELIX: 0.0321

FCONS_SCORE: 1.2209

RIG_SCORE: 0.7265

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A784V	TCGA-A5-A0G1	UCEC	TCGA	PLTPTLS	DEG_SCF_FBW7_1	0.1667
p.A784V	DO42472	UCEC	ICGC	PLTPTLS	DEG_SCF_FBW7_1	0.1667
p.R798H	TCGA-AA-3864	COAD	TCGA	PLTPTLS	DEG_SCF_FBW7_1	0.2778
p.R798H	DO8490	COAD	ICGC	PLTPTLS	DEG_SCF_FBW7_1	0.2778
p.R798C	TCGA-AX-A1CE	UCEC	TCGA	PLTPTLS	DEG_SCF_FBW7_1	0.2778
p.R798C	DO42280	UCEC	ICGC	PLTPTLS	DEG_SCF_FBW7_1	0.2778
p.A784T	DO234374	ESAD	ICGC	PLTPTLS	DEG_SCF_FBW7_1	0.1667
p.R798L	DO228948	LICA	ICGC	PLTPTLS	DEG_SCF_FBW7_1	0.2778
p.A792S	DO229041	LICA	ICGC	PLTPTLS	DEG_SCF_FBW7_1	0.7588
p.P797L	DO222714	MELA	ICGC	PLTPTLS	DEG_SCF_FBW7_1	0.3056
p.T783S	SIDM00025	Head and Neck Carcinoma	GDSC	PLTPTLS	DEG_SCF_FBW7_1	0.1389
p.T783S	UDSCC2	upper_aerodigestive_tract	COSMIC	PLTPTLS	DEG_SCF_FBW7_1	0.1389
p.G801R	ACH-000988	Endometrial/Uterine Cancer	CCLE	PLTPTLS	DEG_SCF_FBW7_1	0.6389
p.S792C	CAL-148	breast	COSMIC	PLTPTLS	DEG_SCF_FBW7_1	0.7541

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43151	Methylcytosine dioxygenase TET3	DEG_SCF_FBW7_1	790:796	PLTPTLS	FBXW7	0.9994	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons