DegronMD

Uniprot ID: O43151

Source protein: Methylcytosine dioxygenase TET3

Source gene: TET3

Class: LIG_APCC_ABBAyCdc20_2

Location: 535:541

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9144

ASA_SCORE: 119.4143

COIL: 0.551

CONS_SCORE: 0.3907

DSS_SCORE: 0.5976

HELIX: 0.427

FCONS_SCORE: 1.0685

RIG_SCORE: 0.7211

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P525L	TCGA-B6-A0RS	BRCA	TCGA	KRSLFLE	LIG_APCC_ABBAyCdc20_2	0.0556
p.P525L	DO4012	BRCA	ICGC	KRSLFLE	LIG_APCC_ABBAyCdc20_2	0.0556
p.S535I	TCGA-DF-A2KN	UCEC	TCGA	KRSLFLE	LIG_APCC_ABBAyCdc20_2	0.7341
p.S535I	DO223282	UCEC	ICGC	KRSLFLE	LIG_APCC_ABBAyCdc20_2	0.7341
p.R538S	TCGA-FV-A495	LIHC	TCGA	KRSLFLE	LIG_APCC_ABBAyCdc20_2	0.7427
p.R538S	DO44890	LIHC	ICGC	KRSLFLE	LIG_APCC_ABBAyCdc20_2	0.7427
p.A530P	DO230309	COCA	ICGC	KRSLFLE	LIG_APCC_ABBAyCdc20_2	0.1944
p.D545N	SIDM01266	Colorectal Carcinoma	GDSC	KRSLFLE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R536H	SIDM01113	Other Sarcomas	GDSC	KRSLFLE	LIG_APCC_ABBAyCdc20_2	0.7133
p.R536H	SK-UT-1	soft_tissue	COSMIC	KRSLFLE	LIG_APCC_ABBAyCdc20_2	0.7133
p.V543G	SIDM01229	Neuroblastoma	GDSC	KRSLFLE	LIG_APCC_ABBAyCdc20_2	0.2778
p.V543G	BE2-M17	autonomic_ganglia	COSMIC	KRSLFLE	LIG_APCC_ABBAyCdc20_2	0.2778
p.T546I	SIDM00256	Neuroblastoma	GDSC	KRSLFLE	LIG_APCC_ABBAyCdc20_2	0.1944
p.S528F	ACH-000509	Lymphoma	CCLE	KRSLFLE	LIG_APCC_ABBAyCdc20_2	0.1389
p.S528F	ACH-002240	Lymphoma	CCLE	KRSLFLE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R538G	ACH-000786	Lymphoma	CCLE	KRSLFLE	LIG_APCC_ABBAyCdc20_2	0.7568
p.R538M	ACH-000929	Lung Cancer	CCLE	KRSLFLE	LIG_APCC_ABBAyCdc20_2	0.8632
p.H550Y	NCI-SNU-16	stomach	COSMIC	KRSLFLE	LIG_APCC_ABBAyCdc20_2	0.0833
p.H550Y	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	KRSLFLE	LIG_APCC_ABBAyCdc20_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43151	Methylcytosine dioxygenase TET3	LIG_APCC_ABBAyCdc20_2	535:541	KRSLFLE	APC,CDC20,FZR1	0.9144	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons