DegronMD

Uniprot ID: O43151

Source protein: Methylcytosine dioxygenase TET3

Source gene: TET3

Class: DEG_SCF_FBW7_2

Location: 1417:1424

E3 ligase: FBXW7

DEGRON score: 0.9804

ASA_SCORE: 87.5

COIL: 0.8925

CONS_SCORE: 0.3556

DSS_SCORE: 0.7061

HELIX: 0.0598

FCONS_SCORE: 1.1673

RIG_SCORE: 0.6533

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1421M	TCGA-A5-A0G2	UCEC	TCGA	MGKTPLSE	DEG_SCF_FBW7_2	0.711
p.L1421M	DO41235	UCEC	ICGC	MGKTPLSE	DEG_SCF_FBW7_2	0.711
p.S1409L	TCGA-AP-A0LM	UCEC	TCGA	MGKTPLSE	DEG_SCF_FBW7_2	0.1111
p.S1409L	DO43306	UCEC	ICGC	MGKTPLSE	DEG_SCF_FBW7_2	0.1111
p.P1424H	TCGA-D3-A2J8	SKCM	TCGA	MGKTPLSE	DEG_SCF_FBW7_2	0.7694
p.P1424H	DO37778	SKCM	ICGC	MGKTPLSE	DEG_SCF_FBW7_2	0.7694
p.A1434V	TCGA-L5-A43J	ESCA	TCGA	MGKTPLSE	DEG_SCF_FBW7_2	0.0556
p.A1410V	DO229272	THCA	ICGC	MGKTPLSE	DEG_SCF_FBW7_2	0.1389
p.E1424D	SIDM00832	Colorectal Carcinoma	GDSC	MGKTPLSE	DEG_SCF_FBW7_2	0.6758
p.E1424D	SW948	large_intestine	COSMIC	MGKTPLSE	DEG_SCF_FBW7_2	0.6758
p.E1424G	SIDM00282	Colorectal Carcinoma	GDSC	MGKTPLSE	DEG_SCF_FBW7_2	0.7199
p.E1424G	CW-2	large_intestine	COSMIC	MGKTPLSE	DEG_SCF_FBW7_2	0.7199
p.S1411P	NCI-H2081	lung	COSMIC	MGKTPLSE	DEG_SCF_FBW7_2	0.1667
p.S1411P	A101D	skin	COSMIC	MGKTPLSE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43151	Methylcytosine dioxygenase TET3	DEG_SCF_FBW7_2	1417:1424	MGKTPLSE	FBXW7	0.9804	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons