DegronMD - Q9BZL4(PPP1R12C)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S336Y	TCGA-22-5491	LUSC	TCGA	APSSS	DEG_SPOP_SBC_1	334:338	Mutation altering degron motif	0.8231
p.S336Y	DO26420	LUSC	ICGC	APSSS	DEG_SPOP_SBC_1	334:338	Mutation altering degron motif	0.8231
p.R328W	TCGA-55-7283	LUAD	TCGA	APSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1667
p.R328W	DO23606	LUAD	ICGC	APSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1667
p.E465D	TCGA-90-7964	LUSC	TCGA	ITPTPS	DEG_SCF_FBW7_1	471:476	Mutation rewiring degron network	0.1667
p.E465D	DO27046	LUSC	ICGC	ITPTPS	DEG_SCF_FBW7_1	471:476	Mutation rewiring degron network	0.1667
p.A334V	TCGA-AA-3514	COAD	TCGA	APSSS	DEG_SPOP_SBC_1	334:338	Mutation altering degron motif	0.5825
p.A334V	DO10486	COAD	ICGC	APSSS	DEG_SPOP_SBC_1	334:338	Mutation altering degron motif	0.5825
p.R470I	TCGA-AX-A2HC	UCEC	TCGA	ITPTPS	DEG_SCF_FBW7_1	471:476	Mutation rewiring degron network	0.3056
p.R470I	DO50672	ORCA	ICGC	ITPTPS	DEG_SCF_FBW7_1	471:476	Mutation rewiring degron network	0.3056
p.R470I	DO41572	UCEC	ICGC	ITPTPS	DEG_SCF_FBW7_1	471:476	Mutation rewiring degron network	0.3056
p.P473L	TCGA-EA-A410	CESC	TCGA	ITPTPS	DEG_SCF_FBW7_1	471:476	Mutation altering degron motif	0.7582
p.P473L	DO49929	CESC	ICGC	ITPTPS	DEG_SCF_FBW7_1	471:476	Mutation altering degron motif	0.7582
p.P473L	DO229051	LICA	ICGC	ITPTPS	DEG_SCF_FBW7_1	471:476	Mutation altering degron motif	0.7582
p.S336F	TCGA-EE-A3JI	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	334:338	Mutation altering degron motif	0.9093
p.S336F	DO47268	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	334:338	Mutation altering degron motif	0.9093
p.L468I	DO229018	LICA	ICGC	ITPTPS	DEG_SCF_FBW7_1	471:476	Mutation rewiring degron network	0.25
p.R467H	DO27907	ORCA	ICGC	ITPTPS	DEG_SCF_FBW7_1	471:476	Mutation rewiring degron network	0.2222
p.V484I	DO229208	THCA	ICGC	ITPTPS	DEG_SCF_FBW7_1	471:476	Mutation rewiring degron network	0.1111
p.P480L	SIDM00096	T-Cell Non-Hodgkin's Lymphoma	GDSC	ITPTPS	DEG_SCF_FBW7_1	471:476	Mutation rewiring degron network	0.2222
p.P480L	ACH-000338	Lymphoma	CCLE	ITPTPS	DEG_SCF_FBW7_1	471:476	Mutation rewiring degron network	0.2222
p.S327N	SIDM00930	Osteosarcoma	GDSC	APSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1389
p.S327N	ACH-001715	Bone Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1389
p.S327N	CAL-72	bone	COSMIC	APSSS	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.1389
p.S483F	ACH-000580	Skin Cancer	CCLE	ITPTPS	DEG_SCF_FBW7_1	471:476	Mutation rewiring degron network	0.1389
p.R483Q	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	ITPTPS	DEG_SCF_FBW7_1	471:476	Mutation rewiring degron network	0.1389
p.R475H	SNU-1040	large intestine	COSMIC	ITPTPS	DEG_SCF_FBW7_1	471:476	Mutation altering degron motif	0.8244
p.R475H	RKO	large intestine	COSMIC	ITPTPS	DEG_SCF_FBW7_1	471:476	Mutation altering degron motif	0.8244
p.P334S	MOLM-13	haematopoietic and lymphoid tissue	COSMIC	APSSS	DEG_SPOP_SBC_1	334:338	Mutation altering degron motif	0.6752
p.K473N	COLO-824	breast	COSMIC	ITPTPS	DEG_SCF_FBW7_1	471:476	Mutation altering degron motif	0.6918

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPP1R12C

UniProt ID: Q9BZL4

Entrez ID: 54776

Protein name: Protein phosphatase 1 regulatory subunit 12C (Protein phosphatase 1 myosin-binding subunit of 85 kDa) (Protein phosphatase 1 myosin-binding subunit p85)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPP1R12C in