DegronMD

Uniprot ID: Q9BZL4

Source protein: Protein phosphatase 1 regulatory subunit 12C

Source gene: PPP1R12C

Class: DEG_SCF_FBW7_1

Location: 471:476

E3 ligase: FBXW7

DEGRON score: 0.9965

ASA_SCORE: 96.7667

COIL: 0.9752

CONS_SCORE: 0.479

DSS_SCORE: 0.5994

HELIX: 0.0117

FCONS_SCORE: 1.165

RIG_SCORE: 0.6458

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E465D	TCGA-90-7964	LUSC	TCGA	ITPTPS	DEG_SCF_FBW7_1	0.1667
p.E465D	DO27046	LUSC	ICGC	ITPTPS	DEG_SCF_FBW7_1	0.1667
p.R470I	TCGA-AX-A2HC	UCEC	TCGA	ITPTPS	DEG_SCF_FBW7_1	0.3056
p.R470I	DO50672	ORCA	ICGC	ITPTPS	DEG_SCF_FBW7_1	0.3056
p.R470I	DO41572	UCEC	ICGC	ITPTPS	DEG_SCF_FBW7_1	0.3056
p.P473L	TCGA-EA-A410	CESC	TCGA	ITPTPS	DEG_SCF_FBW7_1	0.7582
p.P473L	DO49929	CESC	ICGC	ITPTPS	DEG_SCF_FBW7_1	0.7582
p.P473L	DO229051	LICA	ICGC	ITPTPS	DEG_SCF_FBW7_1	0.7582
p.L468I	DO229018	LICA	ICGC	ITPTPS	DEG_SCF_FBW7_1	0.25
p.R467H	DO27907	ORCA	ICGC	ITPTPS	DEG_SCF_FBW7_1	0.2222
p.V484I	DO229208	THCA	ICGC	ITPTPS	DEG_SCF_FBW7_1	0.1111
p.P480L	SIDM00096	T-Cell Non-Hodgkin's Lymphoma	GDSC	ITPTPS	DEG_SCF_FBW7_1	0.2222
p.P480L	ACH-000338	Lymphoma	CCLE	ITPTPS	DEG_SCF_FBW7_1	0.2222
p.S483F	ACH-000580	Skin Cancer	CCLE	ITPTPS	DEG_SCF_FBW7_1	0.1389
p.R483Q	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	ITPTPS	DEG_SCF_FBW7_1	0.1389
p.R475H	SNU-1040	large_intestine	COSMIC	ITPTPS	DEG_SCF_FBW7_1	0.8244
p.R475H	RKO	large_intestine	COSMIC	ITPTPS	DEG_SCF_FBW7_1	0.8244
p.K473N	COLO-824	breast	COSMIC	ITPTPS	DEG_SCF_FBW7_1	0.6918

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BZL4	Protein phosphatase 1 regulatory subunit 12C	DEG_SCF_FBW7_1	471:476	ITPTPS	FBXW7	0.9965	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons