DegronMD

Uniprot ID: Q02413

Source protein: Desmoglein-1

Source gene: DSG1

Class: DEG_ODPH_VHL_1

Location: 899:911

E3 ligase: VHL

DEGRON score: 0.9853

ASA_SCORE: 67.3385

COIL: 0.7773

CONS_SCORE: 0.7109

DSS_SCORE: 0.4507

HELIX: 0.0316

FCONS_SCORE: 1.0361

RIG_SCORE: 0.6887

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A900E	TCGA-AP-A051	UCEC	TCGA	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	0.7701
p.A900E	DO42673	UCEC	ICGC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	0.7701
p.S902I	TCGA-AP-A059	UCEC	TCGA	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	0.623
p.S902I	DO41361	UCEC	ICGC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	0.623
p.S890L	TCGA-AP-A0LM	UCEC	TCGA	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	0.0833
p.S890L	TCGA-AX-A1CE	UCEC	TCGA	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	0.0833
p.S890L	DO222762	COCA	ICGC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	0.0833
p.S890L	DO43306	UCEC	ICGC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	0.0833
p.S890L	DO42280	UCEC	ICGC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	0.0833
p.S890L	SIDM00217	Colorectal Carcinoma	GDSC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	0.0833
p.S890L	ACH-000999	Colon/Colorectal Cancer	CCLE	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	0.0833
p.S890L	SNU-1040	large_intestine	COSMIC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	0.0833
p.E916D	TCGA-AX-A1CE	UCEC	TCGA	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	0.1944
p.E916D	DO42280	UCEC	ICGC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	0.1944
p.V894G	TCGA-BR-4191	STAD	TCGA	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	0.1944
p.V894G	DO38891	STAD	ICGC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	0.1944
p.P914S	TCGA-EE-A29C	SKCM	TCGA	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	0.25
p.P914S	DO222727	MELA	ICGC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	0.25
p.P914S	DO38028	SKCM	ICGC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	0.25
p.H913Y	TCGA-EE-A29D	SKCM	TCGA	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	0.2778
p.H913Y	DO38123	SKCM	ICGC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	0.2778
p.L909P	DO222769	COCA	ICGC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	0.7582
p.V894A	DO234258	ESAD	ICGC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	0.1944
p.T910P	DO51004	LAML	ICGC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	0.5919
p.E916V	DO228202	LICA	ICGC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	0.1944
p.S902N	SIDM00151	Ovarian Carcinoma	GDSC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	0.5958
p.S902N	ACH-000966	Ovarian Cancer	CCLE	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	0.5958
p.S902N	IGROV-1	ovary	COSMIC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	0.5958
p.V921G	SIDM00516	Melanoma	GDSC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	0.0556
p.V921G	ACH-002166	Skin Cancer	CCLE	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	0.0556
p.V921G	MZ7-mel	skin	COSMIC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	0.0556
p.A900T	SIDM01612	Endometrial Carcinoma	GDSC	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	0.7139
p.A900T	ACH-000946	Endometrial/Uterine Cancer	CCLE	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	0.7139
p.V921L	ACH-001367	Neuroblastoma	CCLE	IAPSSSLPTSLTI	DEG_ODPH_VHL_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IAPSSSLPTSLTI

Degron related mutations and impact score

Drug responses associated with DSG1 mutations

All proteins holding degron of IAPSSSLPTSLTI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02413	Desmoglein-1	DEG_ODPH_VHL_1	899:911	IAPSSSLPTSLTI	VHL	0.9853	More...