DegronMD

Uniprot ID: Q02413

Source protein: Desmoglein-1

Source gene: DSG1

Class: LIG_APCC_ABBA_1

Location: 937:942

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.942

ASA_SCORE: 81.9

COIL: 0.7083

CONS_SCORE: 0.6652

DSS_SCORE: 0.3742

HELIX: 0.0667

FCONS_SCORE: 0.9802

RIG_SCORE: 0.7516

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G932S	TCGA-2W-A8YY	CESC	TCGA	LSMHPE	LIG_APCC_ABBA_1	0.1944
p.G932S	TCGA-EJ-A65E	PRAD	TCGA	LSMHPE	LIG_APCC_ABBA_1	0.1944
p.G932S	DO223732	CESC	ICGC	LSMHPE	LIG_APCC_ABBA_1	0.1944
p.G932S	DO49754	PRAD	ICGC	LSMHPE	LIG_APCC_ABBA_1	0.1944
p.G932S	SIDM00282	Colorectal Carcinoma	GDSC	LSMHPE	LIG_APCC_ABBA_1	0.1944
p.G932S	ACH-000998	Colon/Colorectal Cancer	CCLE	LSMHPE	LIG_APCC_ABBA_1	0.1944
p.S938C	TCGA-66-2788	LUSC	TCGA	LSMHPE	LIG_APCC_ABBA_1	0.643
p.S938C	DO26749	LUSC	ICGC	LSMHPE	LIG_APCC_ABBA_1	0.643
p.E942K	TCGA-A5-A1OF	UCEC	TCGA	LSMHPE	LIG_APCC_ABBA_1	0.7022
p.E942K	TCGA-B5-A11N	UCEC	TCGA	LSMHPE	LIG_APCC_ABBA_1	0.7022
p.E942K	TCGA-EE-A2M5	SKCM	TCGA	LSMHPE	LIG_APCC_ABBA_1	0.7022
p.E942K	TCGA-S9-A7IQ	LGG	TCGA	LSMHPE	LIG_APCC_ABBA_1	0.7022
p.E942K	DO50204	LGG	ICGC	LSMHPE	LIG_APCC_ABBA_1	0.7022
p.E942K	DO220903	MELA	ICGC	LSMHPE	LIG_APCC_ABBA_1	0.7022
p.E942K	DO222423	MELA	ICGC	LSMHPE	LIG_APCC_ABBA_1	0.7022
p.E942K	DO37425	SKCM	ICGC	LSMHPE	LIG_APCC_ABBA_1	0.7022
p.E942K	DO42568	UCEC	ICGC	LSMHPE	LIG_APCC_ABBA_1	0.7022
p.E942K	DO41458	UCEC	ICGC	LSMHPE	LIG_APCC_ABBA_1	0.7022
p.M933K	TCGA-D3-A1Q6	SKCM	TCGA	LSMHPE	LIG_APCC_ABBA_1	0.2222
p.M933K	DO37450	SKCM	ICGC	LSMHPE	LIG_APCC_ABBA_1	0.2222
p.M933I	TCGA-DK-A6B6	BLCA	TCGA	LSMHPE	LIG_APCC_ABBA_1	0.2222
p.M933I	TCGA-IH-A3EA	SKCM	TCGA	LSMHPE	LIG_APCC_ABBA_1	0.2222
p.M933I	DO48576	BLCA	ICGC	LSMHPE	LIG_APCC_ABBA_1	0.2222
p.M933I	DO37667	SKCM	ICGC	LSMHPE	LIG_APCC_ABBA_1	0.2222
p.H947Y	TCGA-FW-A3R5	SKCM	TCGA	LSMHPE	LIG_APCC_ABBA_1	0.1944
p.H947Y	DO37406	SKCM	ICGC	LSMHPE	LIG_APCC_ABBA_1	0.1944
p.I927N	TCGA-PK-A5HA	ACC	TCGA	LSMHPE	LIG_APCC_ABBA_1	0.0556
p.E942D	DO229026	LICA	ICGC	LSMHPE	LIG_APCC_ABBA_1	0.5647
p.T930I	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	LSMHPE	LIG_APCC_ABBA_1	0.1389
p.T930I	ACH-000062	Lung Cancer	CCLE	LSMHPE	LIG_APCC_ABBA_1	0.1389
p.T930I	RERF-LC-MS	lung	COSMIC	LSMHPE	LIG_APCC_ABBA_1	0.1389
p.L943F	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	LSMHPE	LIG_APCC_ABBA_1	0.3056
p.L943F	ACH-000951	Lung Cancer	CCLE	LSMHPE	LIG_APCC_ABBA_1	0.3056
p.L943F	NCI-H2342	lung	COSMIC	LSMHPE	LIG_APCC_ABBA_1	0.3056
p.M933T	SIDM00655	Other Solid Cancers	GDSC	LSMHPE	LIG_APCC_ABBA_1	0.2222
p.M933T	ACH-001578	Embryonal Cancer	CCLE	LSMHPE	LIG_APCC_ABBA_1	0.2222
p.M933T	NCCIT	testis	COSMIC	LSMHPE	LIG_APCC_ABBA_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LSMHPE

Degron related mutations and impact score

Drug responses associated with DSG1 mutations

All proteins holding degron of LSMHPE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02413	Desmoglein-1	LIG_APCC_ABBA_1	937:942	LSMHPE	APC,CDC20,FZR1	0.942	More...