DegronMD

Uniprot ID: P46934

Source protein: E3 ubiquitin-protein ligase NEDD4

Source gene: NEDD4

Class: CBL_PTK

Location: 188:196

E3 ligase: CBL

DEGRON score: 0.9054

ASA_SCORE: 66.3556

COIL: 0.8262

CONS_SCORE: 0.3697

DSS_SCORE: 0.4303

HELIX: 0.0453

FCONS_SCORE: 0.9994

RIG_SCORE: 0.685

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L202F	TCGA-BF-A1PU	SKCM	TCGA	DSSSYTFPP	CBL_PTK	0.1667
p.L202F	DO50278	SKCM	ICGC	DSSSYTFPP	CBL_PTK	0.1667
p.N205H	TCGA-BR-8680	STAD	TCGA	DSSSYTFPP	CBL_PTK	0.0833
p.N205H	DO47769	STAD	ICGC	DSSSYTFPP	CBL_PTK	0.0833
p.N183K	DO229037	LICA	ICGC	DSSSYTFPP	CBL_PTK	0.1944
p.D188E	DO229045	LICA	ICGC	DSSSYTFPP	CBL_PTK	0.6758
p.S187N	SIDM02050	Colorectal Carcinoma	GDSC	DSSSYTFPP	CBL_PTK	0.3056
p.V185D	SIDM00529	Breast Carcinoma	GDSC	DSSSYTFPP	CBL_PTK	0.25
p.V185D	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	DSSSYTFPP	CBL_PTK	0.25
p.V185D	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	DSSSYTFPP	CBL_PTK	0.25
p.V185D	SIDM00863	Burkitt's Lymphoma	GDSC	DSSSYTFPP	CBL_PTK	0.25
p.G204E	SIDM00449	B-Lymphoblastic Leukemia	GDSC	DSSSYTFPP	CBL_PTK	0.1111
p.G204E	ACH-000922	Leukemia	CCLE	DSSSYTFPP	CBL_PTK	0.1111
p.G204E	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	DSSSYTFPP	CBL_PTK	0.1111
p.S189G	SIDM01088	Endometrial Carcinoma	GDSC	DSSSYTFPP	CBL_PTK	0.5882
p.S189G	ACH-000965	Endometrial/Uterine Cancer	CCLE	DSSSYTFPP	CBL_PTK	0.5882
p.S189G	RL95-2	endometrium	COSMIC	DSSSYTFPP	CBL_PTK	0.5882
p.S191G	SIDM01619	Endometrial Carcinoma	GDSC	DSSSYTFPP	CBL_PTK	0.5882
p.S191G	ACH-000984	Endometrial/Uterine Cancer	CCLE	DSSSYTFPP	CBL_PTK	0.5882
p.I203N	SNU-81	large_intestine	COSMIC	DSSSYTFPP	CBL_PTK	0.1389
p.Q188R	CHSA8926	bone	COSMIC	DSSSYTFPP	CBL_PTK	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46934	E3 ubiquitin-protein ligase NEDD4	CBL_PTK	188:196	DSSSYTFPP	CBL	0.9054	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons