DegronMD - P46934(NEDD4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V66I	TCGA-06-0126	GBM	TCGA	MKLTPRQT	DEG_SCF_FBW7_1	49:56	Mutation rewiring degron network	0.0556
p.V66I	DO11519	GBM	ICGC	MKLTPRQT	DEG_SCF_FBW7_1	49:56	Mutation rewiring degron network	0.0556
p.P726A	TCGA-A6-4105	COAD	TCGA	PASSS	DEG_SPOP_SBC_1	735:739	Mutation rewiring degron network	0.0833
p.S42L	TCGA-AJ-A2QM	UCEC	TCGA	MKLTPRQT	DEG_SCF_FBW7_1	49:56	Mutation rewiring degron network	0.1389
p.S42L	DO43690	UCEC	ICGC	MKLTPRQT	DEG_SCF_FBW7_1	49:56	Mutation rewiring degron network	0.1389
p.L202F	TCGA-BF-A1PU	SKCM	TCGA	DSSSYTFPP	CBL_PTK	188:196	Mutation rewiring degron network	0.1667
p.L202F	DO50278	SKCM	ICGC	DSSSYTFPP	CBL_PTK	188:196	Mutation rewiring degron network	0.1667
p.Q729H	TCGA-BR-6566	STAD	TCGA	PASSS	DEG_SPOP_SBC_1	735:739	Mutation rewiring degron network	0.1667
p.N205H	TCGA-BR-8680	STAD	TCGA	DSSSYTFPP	CBL_PTK	188:196	Mutation rewiring degron network	0.0833
p.N205H	DO47769	STAD	ICGC	DSSSYTFPP	CBL_PTK	188:196	Mutation rewiring degron network	0.0833
p.T43A	TCGA-V4-A9F4	UVM	TCGA	MKLTPRQT	DEG_SCF_FBW7_1	49:56	Mutation rewiring degron network	0.1667
p.M52L	DO51208	BRCA	ICGC	MKLTPRQT	DEG_SCF_FBW7_1	49:56	Mutation altering degron motif	0.711
p.V732M	DO8224	COAD	ICGC	PASSS	DEG_SPOP_SBC_1	735:739	Mutation rewiring degron network	0.25
p.V732M	DO42825	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	735:739	Mutation rewiring degron network	0.25
p.R40W	DO227634	COCA	ICGC	MKLTPRQT	DEG_SCF_FBW7_1	49:56	Mutation rewiring degron network	0.0833
p.Q60R	DO229005	COCA	ICGC	MKLTPRQT	DEG_SCF_FBW7_1	49:56	Mutation rewiring degron network	0.2222
p.Q60R	SIDM00231	Kidney Carcinoma	GDSC	MKLTPRQT	DEG_SCF_FBW7_1	49:56	Mutation rewiring degron network	0.2222
p.Q60R	SIDM00054	Pancreatic Carcinoma	GDSC	MKLTPRQT	DEG_SCF_FBW7_1	49:56	Mutation rewiring degron network	0.2222
p.Q60R	SIDM01443	Gastric Carcinoma	GDSC	MKLTPRQT	DEG_SCF_FBW7_1	49:56	Mutation rewiring degron network	0.2222
p.T43M	DO228123	EOPC	ICGC	MKLTPRQT	DEG_SCF_FBW7_1	49:56	Mutation rewiring degron network	0.1667
p.A736E	DO228948	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	735:739	Mutation altering degron motif	0.659
p.P735T	DO228986	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	735:739	Mutation altering degron motif	0.7031
p.T43K	DO229031	LICA	ICGC	MKLTPRQT	DEG_SCF_FBW7_1	49:56	Mutation rewiring degron network	0.1667
p.Q60K	DO229035	LICA	ICGC	MKLTPRQT	DEG_SCF_FBW7_1	49:56	Mutation rewiring degron network	0.2222
p.S738R	DO229038	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	735:739	Mutation altering degron motif	0.7427
p.N183K	DO229037	LICA	ICGC	DSSSYTFPP	CBL_PTK	188:196	Mutation rewiring degron network	0.1944
p.D188E	DO229045	LICA	ICGC	DSSSYTFPP	CBL_PTK	188:196	Mutation altering degron motif	0.6758
p.S737L	DO220913	MELA	ICGC	PASSS	DEG_SPOP_SBC_1	735:739	Mutation altering degron motif	0.7667
p.G54R	DO222542	MELA	ICGC	MKLTPRQT	DEG_SCF_FBW7_1	49:56	Mutation altering degron motif	0.7568
p.P53L	DO222908	MELA	ICGC	MKLTPRQT	DEG_SCF_FBW7_1	49:56	Mutation altering degron motif	0.7582
p.K50M	DO34873	PACA	ICGC	MKLTPRQT	DEG_SCF_FBW7_1	49:56	Mutation altering degron motif	0.6951
p.D50Y	DO231249	THCA	ICGC	MKLTPRQT	DEG_SCF_FBW7_1	49:56	Mutation altering degron motif	0.7325
p.T61A	DO50075	UCEC	ICGC	MKLTPRQT	DEG_SCF_FBW7_1	49:56	Mutation rewiring degron network	0.1944
p.A736T	DO43971	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	735:739	Mutation altering degron motif	0.6028
p.S187N	SIDM02050	Colorectal Carcinoma	GDSC	DSSSYTFPP	CBL_PTK	188:196	Mutation rewiring degron network	0.3056
p.N65K	SIDM01265	Plasma Cell Myeloma	GDSC	MKLTPRQT	DEG_SCF_FBW7_1	49:56	Mutation rewiring degron network	0.0833
p.V185D	SIDM00529	Breast Carcinoma	GDSC	DSSSYTFPP	CBL_PTK	188:196	Mutation rewiring degron network	0.25
p.V185D	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	DSSSYTFPP	CBL_PTK	188:196	Mutation rewiring degron network	0.25
p.V185D	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	DSSSYTFPP	CBL_PTK	188:196	Mutation rewiring degron network	0.25
p.V185D	SIDM00863	Burkitt's Lymphoma	GDSC	DSSSYTFPP	CBL_PTK	188:196	Mutation rewiring degron network	0.25
p.G204E	SIDM00449	B-Lymphoblastic Leukemia	GDSC	DSSSYTFPP	CBL_PTK	188:196	Mutation rewiring degron network	0.1111
p.G204E	ACH-000922	Leukemia	CCLE	DSSSYTFPP	CBL_PTK	188:196	Mutation rewiring degron network	0.1111
p.G204E	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	DSSSYTFPP	CBL_PTK	188:196	Mutation rewiring degron network	0.1111
p.S189G	SIDM01088	Endometrial Carcinoma	GDSC	DSSSYTFPP	CBL_PTK	188:196	Mutation altering degron motif	0.5882
p.S189G	ACH-000965	Endometrial/Uterine Cancer	CCLE	DSSSYTFPP	CBL_PTK	188:196	Mutation altering degron motif	0.5882
p.S189G	RL95-2	endometrium	COSMIC	DSSSYTFPP	CBL_PTK	188:196	Mutation altering degron motif	0.5882
p.I726M	SIDM01588	Endometrial Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	735:739	Mutation rewiring degron network	0.0833
p.S191G	SIDM01619	Endometrial Carcinoma	GDSC	DSSSYTFPP	CBL_PTK	188:196	Mutation altering degron motif	0.5882
p.S191G	ACH-000984	Endometrial/Uterine Cancer	CCLE	DSSSYTFPP	CBL_PTK	188:196	Mutation altering degron motif	0.5882
p.T61I	ACH-000804	Neuroblastoma	CCLE	MKLTPRQT	DEG_SCF_FBW7_1	49:56	Mutation rewiring degron network	0.1944
p.T749I	5637	urinary tract	COSMIC	PASSS	DEG_SPOP_SBC_1	735:739	Mutation rewiring degron network	0.0556
p.Q729K	LCLC-103H	lung	COSMIC	PASSS	DEG_SPOP_SBC_1	735:739	Mutation rewiring degron network	0.1667
p.F741L	NCI-H1869	lung	COSMIC	PASSS	DEG_SPOP_SBC_1	735:739	Mutation rewiring degron network	0.2778
p.F741L	GP5d	large intestine	COSMIC	PASSS	DEG_SPOP_SBC_1	735:739	Mutation rewiring degron network	0.2778
p.I203N	SNU-81	large intestine	COSMIC	DSSSYTFPP	CBL_PTK	188:196	Mutation rewiring degron network	0.1389
p.Q188R	CHSA8926	bone	COSMIC	DSSSYTFPP	CBL_PTK	188:196	Mutation altering degron motif	0.7329

Kaplan plot for NEDD4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NEDD4

UniProt ID: P46934

Entrez ID: 4734

Protein name: E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NEDD4 in