DegronMD

Uniprot ID: P46934

Source protein: E3 ubiquitin-protein ligase NEDD4

Source gene: NEDD4

Class: DEG_SCF_FBW7_1

Location: 49:56

E3 ligase: FBXW7

DEGRON score: 0.5706

ASA_SCORE: 69.7125

COIL: 0.5225

CONS_SCORE: 0.3622

DSS_SCORE: 0.4356

HELIX: 0.1741

FCONS_SCORE: 0.9888

RIG_SCORE: 0.797

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V66I	TCGA-06-0126	GBM	TCGA	MKLTPRQT	DEG_SCF_FBW7_1	0.0556
p.V66I	DO11519	GBM	ICGC	MKLTPRQT	DEG_SCF_FBW7_1	0.0556
p.S42L	TCGA-AJ-A2QM	UCEC	TCGA	MKLTPRQT	DEG_SCF_FBW7_1	0.1389
p.S42L	DO43690	UCEC	ICGC	MKLTPRQT	DEG_SCF_FBW7_1	0.1389
p.T43A	TCGA-V4-A9F4	UVM	TCGA	MKLTPRQT	DEG_SCF_FBW7_1	0.1667
p.M52L	DO51208	BRCA	ICGC	MKLTPRQT	DEG_SCF_FBW7_1	0.711
p.R40W	DO227634	COCA	ICGC	MKLTPRQT	DEG_SCF_FBW7_1	0.0833
p.Q60R	DO229005	COCA	ICGC	MKLTPRQT	DEG_SCF_FBW7_1	0.2222
p.Q60R	SIDM00231	Kidney Carcinoma	GDSC	MKLTPRQT	DEG_SCF_FBW7_1	0.2222
p.Q60R	SIDM00054	Pancreatic Carcinoma	GDSC	MKLTPRQT	DEG_SCF_FBW7_1	0.2222
p.Q60R	SIDM01443	Gastric Carcinoma	GDSC	MKLTPRQT	DEG_SCF_FBW7_1	0.2222
p.T43M	DO228123	EOPC	ICGC	MKLTPRQT	DEG_SCF_FBW7_1	0.1667
p.T43K	DO229031	LICA	ICGC	MKLTPRQT	DEG_SCF_FBW7_1	0.1667
p.Q60K	DO229035	LICA	ICGC	MKLTPRQT	DEG_SCF_FBW7_1	0.2222
p.G54R	DO222542	MELA	ICGC	MKLTPRQT	DEG_SCF_FBW7_1	0.7568
p.P53L	DO222908	MELA	ICGC	MKLTPRQT	DEG_SCF_FBW7_1	0.7582
p.K50M	DO34873	PACA	ICGC	MKLTPRQT	DEG_SCF_FBW7_1	0.6951
p.D50Y	DO231249	THCA	ICGC	MKLTPRQT	DEG_SCF_FBW7_1	0.7325
p.T61A	DO50075	UCEC	ICGC	MKLTPRQT	DEG_SCF_FBW7_1	0.1944
p.N65K	SIDM01265	Plasma Cell Myeloma	GDSC	MKLTPRQT	DEG_SCF_FBW7_1	0.0833
p.T61I	ACH-000804	Neuroblastoma	CCLE	MKLTPRQT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46934	E3 ubiquitin-protein ligase NEDD4	DEG_SCF_FBW7_1	49:56	MKLTPRQT	FBXW7	0.5706	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons