DegronMD

Uniprot ID: P56945

Source protein: Breast cancer anti-estrogen resistance protein 1

Source gene: BCAR1

Class: DEG_COP1_1

Location: 112:120

E3 ligase: COP1

DEGRON score: 0.9996

ASA_SCORE: 63.6

COIL: 0.7843

CONS_SCORE: 0.3858

DSS_SCORE: 0.6104

HELIX: 0.0907

FCONS_SCORE: 1.3625

RIG_SCORE: 0.7218

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A118S	TCGA-24-1423	OV	TCGA	DSVYLVPTP	DEG_COP1_1	0.7588
p.A118T	TCGA-A5-A0G1	UCEC	TCGA	DSVYLVPTP	DEG_COP1_1	0.7139
p.A118T	DO42472	UCEC	ICGC	DSVYLVPTP	DEG_COP1_1	0.7139
p.R105H	TCGA-A6-5665	COAD	TCGA	DSVYLVPTP	DEG_COP1_1	0.1389
p.R105H	DO9756	COAD	ICGC	DSVYLVPTP	DEG_COP1_1	0.1389
p.T127A	TCGA-D3-A51G	SKCM	TCGA	DSVYLVPTP	DEG_COP1_1	0.1389
p.T127A	DO47700	SKCM	ICGC	DSVYLVPTP	DEG_COP1_1	0.1389
p.P128T	TCGA-EE-A2M8	SKCM	TCGA	DSVYLVPTP	DEG_COP1_1	0.5556
p.P128T	DO38075	SKCM	ICGC	DSVYLVPTP	DEG_COP1_1	0.5556
p.P128L	TCGA-S9-A6U5	LGG	TCGA	DSVYLVPTP	DEG_COP1_1	0.5556
p.G123D	TCGA-SJ-A6ZI	UCEC	TCGA	DSVYLVPTP	DEG_COP1_1	0.25
p.G123D	TCGA-W3-A828	SKCM	TCGA	DSVYLVPTP	DEG_COP1_1	0.25
p.G123D	DO51273	SKCM	ICGC	DSVYLVPTP	DEG_COP1_1	0.25
p.G123D	DO219784	UCEC	ICGC	DSVYLVPTP	DEG_COP1_1	0.25
p.P122S	DO229010	COCA	ICGC	DSVYLVPTP	DEG_COP1_1	0.2778
p.P122S	DO229013	COCA	ICGC	DSVYLVPTP	DEG_COP1_1	0.2778
p.P122S	DO229016	COCA	ICGC	DSVYLVPTP	DEG_COP1_1	0.2778
p.P122S	DO229003	COCA	ICGC	DSVYLVPTP	DEG_COP1_1	0.2778
p.P122S	DO229005	COCA	ICGC	DSVYLVPTP	DEG_COP1_1	0.2778
p.P122S	DO230659	LAML	ICGC	DSVYLVPTP	DEG_COP1_1	0.2778
p.P122S	DO50996	LAML	ICGC	DSVYLVPTP	DEG_COP1_1	0.2778
p.P122S	DO229232	THCA	ICGC	DSVYLVPTP	DEG_COP1_1	0.2778
p.P118T	DO229019	LICA	ICGC	DSVYLVPTP	DEG_COP1_1	0.7031
p.A129T	SIDM02059	Colorectal Carcinoma	GDSC	DSVYLVPTP	DEG_COP1_1	0.0833
p.G126A	ACH-000823	Esophageal Cancer	CCLE	DSVYLVPTP	DEG_COP1_1	0.1667
p.G126A	KYSE-140	oesophagus	COSMIC	DSVYLVPTP	DEG_COP1_1	0.1667
p.G124A	KYSE-140	oesophagus	COSMIC	DSVYLVPTP	DEG_COP1_1	0.2222
p.G126S	MOLM-13	haematopoietic_and_lymphoid_tissue	COSMIC	DSVYLVPTP	DEG_COP1_1	0.1667
p.V126F	ABC-1	lung	COSMIC	DSVYLVPTP	DEG_COP1_1	0.1667
p.A109T	CW-2	large_intestine	COSMIC	DSVYLVPTP	DEG_COP1_1	0.25
p.S112G	L-363	haematopoietic_and_lymphoid_tissue	COSMIC	DSVYLVPTP	DEG_COP1_1	0.6993
p.G124S	MOLM-13	haematopoietic_and_lymphoid_tissue	COSMIC	DSVYLVPTP	DEG_COP1_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSVYLVPTP

Degron related mutations and impact score

Drug responses associated with BCAR1 mutations

All proteins holding degron of DSVYLVPTP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P56945	Breast cancer anti-estrogen resistance protein 1	DEG_COP1_1	112:120	DSVYLVPTP	COP1	0.9996	More...