DegronMD - P56945(BCAR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A118S	TCGA-24-1423	OV	TCGA	DSVYLVPTP	DEG_COP1_1	112:120	Mutation altering degron motif	0.7588
p.Q307H	TCGA-55-8089	LUAD	TCGA	SVSKDVPDGP	DEG_COP1_1	311:320	Mutation rewiring degron network	0.2222
p.Q307H	DO23690	LUAD	ICGC	SVSKDVPDGP	DEG_COP1_1	311:320	Mutation rewiring degron network	0.2222
p.A118T	TCGA-A5-A0G1	UCEC	TCGA	DSVYLVPTP	DEG_COP1_1	112:120	Mutation altering degron motif	0.7139
p.A118T	DO42472	UCEC	ICGC	DSVYLVPTP	DEG_COP1_1	112:120	Mutation altering degron motif	0.7139
p.R105H	TCGA-A6-5665	COAD	TCGA	DSVYLVPTP	DEG_COP1_1	112:120	Mutation rewiring degron network	0.1389
p.R105H	DO9756	COAD	ICGC	DSVYLVPTP	DEG_COP1_1	112:120	Mutation rewiring degron network	0.1389
p.M318V	TCGA-AJ-A2QO	UCEC	TCGA	SVSKDVPDGP	DEG_COP1_1	311:320	Mutation altering degron motif	0.7208
p.P283L	TCGA-BH-A18G	BRCA	TCGA	GRDPLLEVY	DEG_APCC_DBOX_1	279:287	Mutation altering degron motif	0.7582
p.P283L	DO3686	BRCA	ICGC	GRDPLLEVY	DEG_APCC_DBOX_1	279:287	Mutation altering degron motif	0.7582
p.R301W	TCGA-CA-6718	COAD	TCGA	SVSKDVPDGP	DEG_COP1_1	311:320	Mutation rewiring degron network	0.0556
p.R301W	SIDM01617	Endometrial Carcinoma	GDSC	SVSKDVPDGP	DEG_COP1_1	311:320	Mutation rewiring degron network	0.0556
p.G322C	TCGA-D3-A2JP	SKCM	TCGA	SVSKDVPDGP	DEG_COP1_1	311:320	Mutation rewiring degron network	0.2778
p.G322C	TCGA-FS-A1ZP	SKCM	TCGA	SVSKDVPDGP	DEG_COP1_1	311:320	Mutation rewiring degron network	0.2778
p.K321N	TCGA-D3-A2JP	SKCM	TCGA	SVSKDVPDGP	DEG_COP1_1	311:320	Mutation rewiring degron network	0.3056
p.K321N	DO47407	SKCM	ICGC	SVSKDVPDGP	DEG_COP1_1	311:320	Mutation rewiring degron network	0.3056
p.T127A	TCGA-D3-A51G	SKCM	TCGA	DSVYLVPTP	DEG_COP1_1	112:120	Mutation rewiring degron network	0.1389
p.T127A	DO47700	SKCM	ICGC	DSVYLVPTP	DEG_COP1_1	112:120	Mutation rewiring degron network	0.1389
p.P128T	TCGA-EE-A2M8	SKCM	TCGA	DSVYLVPTP	DEG_COP1_1	112:120	Mutation blocking phosphorylation signal	0.5556
p.P128T	DO38075	SKCM	ICGC	DSVYLVPTP	DEG_COP1_1	112:120	Mutation blocking phosphorylation signal	0.5556
p.E271K	TCGA-EO-A22U	UCEC	TCGA	GRDPLLEVY	DEG_APCC_DBOX_1	279:287	Mutation rewiring degron network	0.1111
p.E271K	DO43755	UCEC	ICGC	GRDPLLEVY	DEG_APCC_DBOX_1	279:287	Mutation rewiring degron network	0.1111
p.Y295C	TCGA-LN-A49S	ESCA	TCGA	GRDPLLEVY	DEG_APCC_DBOX_1	279:287	Mutation substituting flanking lysine	0.2222
p.P128L	TCGA-S9-A6U5	LGG	TCGA	DSVYLVPTP	DEG_COP1_1	112:120	Mutation blocking phosphorylation signal	0.5556
p.G123D	TCGA-SJ-A6ZI	UCEC	TCGA	DSVYLVPTP	DEG_COP1_1	112:120	Mutation rewiring degron network	0.25
p.G123D	TCGA-W3-A828	SKCM	TCGA	DSVYLVPTP	DEG_COP1_1	112:120	Mutation rewiring degron network	0.25
p.G123D	DO51273	SKCM	ICGC	DSVYLVPTP	DEG_COP1_1	112:120	Mutation rewiring degron network	0.25
p.G123D	DO219784	UCEC	ICGC	DSVYLVPTP	DEG_COP1_1	112:120	Mutation rewiring degron network	0.25
p.Y305C	DO5326	BRCA	ICGC	SVSKDVPDGP	DEG_COP1_1	311:320	Mutation rewiring degron network	0.1667
p.L295R	DO9756	COAD	ICGC	GRDPLLEVY	DEG_APCC_DBOX_1	279:287	Mutation substituting flanking lysine	0.2222
p.A322T	DO230326	COCA	ICGC	SVSKDVPDGP	DEG_COP1_1	311:320	Mutation rewiring degron network	0.2778
p.R278Q	DO222840	COCA	ICGC	GRDPLLEVY	DEG_APCC_DBOX_1	279:287	Mutation rewiring degron network	0.3056
p.P122S	DO229010	COCA	ICGC	DSVYLVPTP	DEG_COP1_1	112:120	Mutation rewiring degron network	0.2778
p.P122S	DO229013	COCA	ICGC	DSVYLVPTP	DEG_COP1_1	112:120	Mutation rewiring degron network	0.2778
p.P122S	DO229016	COCA	ICGC	DSVYLVPTP	DEG_COP1_1	112:120	Mutation rewiring degron network	0.2778
p.P122S	DO229003	COCA	ICGC	DSVYLVPTP	DEG_COP1_1	112:120	Mutation rewiring degron network	0.2778
p.P122S	DO229005	COCA	ICGC	DSVYLVPTP	DEG_COP1_1	112:120	Mutation rewiring degron network	0.2778
p.P122S	DO230659	LAML	ICGC	DSVYLVPTP	DEG_COP1_1	112:120	Mutation rewiring degron network	0.2778
p.P122S	DO50996	LAML	ICGC	DSVYLVPTP	DEG_COP1_1	112:120	Mutation rewiring degron network	0.2778
p.P122S	DO229232	THCA	ICGC	DSVYLVPTP	DEG_COP1_1	112:120	Mutation rewiring degron network	0.2778
p.P316S	DO233207	GACA	ICGC	SVSKDVPDGP	DEG_COP1_1	311:320	Mutation altering degron motif	0.6752
p.P118T	DO229019	LICA	ICGC	DSVYLVPTP	DEG_COP1_1	112:120	Mutation altering degron motif	0.7031
p.Q310K	DO229036	LICA	ICGC	SVSKDVPDGP	DEG_COP1_1	311:320	Mutation rewiring degron network	0.3056
p.Q292K	DO229045	LICA	ICGC	GRDPLLEVY	DEG_APCC_DBOX_1	279:287	Mutation blocking phosphorylation signal	0.6389
p.P269H	DO232224	PBCA	ICGC	GRDPLLEVY	DEG_APCC_DBOX_1	279:287	Mutation blocking phosphorylation signal	0.5
p.Y324H	DO220073	SARC	ICGC	SVSKDVPDGP	DEG_COP1_1	311:320	Mutation rewiring degron network	0.2222
p.G274C	DO37703	SKCM	ICGC	GRDPLLEVY	DEG_APCC_DBOX_1	279:287	Mutation rewiring degron network	0.1944
p.G274C	DO47407	SKCM	ICGC	GRDPLLEVY	DEG_APCC_DBOX_1	279:287	Mutation rewiring degron network	0.1944
p.M270V	DO42177	UCEC	ICGC	GRDPLLEVY	DEG_APCC_DBOX_1	279:287	Mutation rewiring degron network	0.0833
p.R317K	DO43755	UCEC	ICGC	SVSKDVPDGP	DEG_COP1_1	311:320	Mutation altering degron motif	0.7237
p.A129T	SIDM02059	Colorectal Carcinoma	GDSC	DSVYLVPTP	DEG_COP1_1	112:120	Mutation rewiring degron network	0.0833
p.Y280H	SIDM01307	Colorectal Carcinoma	GDSC	GRDPLLEVY	DEG_APCC_DBOX_1	279:287	Mutation altering degron motif	0.7229
p.P305L	SIDM01175	Other Sarcomas	GDSC	SVSKDVPDGP	DEG_COP1_1	311:320	Mutation rewiring degron network	0.1667
p.V320F	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	SVSKDVPDGP	DEG_COP1_1	311:320	Mutation altering degron motif	0.7068
p.V320F	ABC-1	lung	COSMIC	SVSKDVPDGP	DEG_COP1_1	311:320	Mutation altering degron motif	0.7068
p.A312V	SIDM00217	Colorectal Carcinoma	GDSC	SVSKDVPDGP	DEG_COP1_1	311:320	Mutation altering degron motif	0.6936
p.A312V	SNU-1040	large intestine	COSMIC	SVSKDVPDGP	DEG_COP1_1	311:320	Mutation altering degron motif	0.6936
p.N324S	SIDM01686	Chronic Myelogenous Leukemia	GDSC	SVSKDVPDGP	DEG_COP1_1	311:320	Mutation rewiring degron network	0.2222
p.K314M	ACH-000207	Head and Neck Cancer	CCLE	SVSKDVPDGP	DEG_COP1_1	311:320	Mutation altering degron motif	0.6951
p.V274F	ACH-000528	Lung Cancer	CCLE	GRDPLLEVY	DEG_APCC_DBOX_1	279:287	Mutation rewiring degron network	0.1944
p.V274F	ABC-1	lung	COSMIC	GRDPLLEVY	DEG_APCC_DBOX_1	279:287	Mutation rewiring degron network	0.1944
p.G126A	ACH-000823	Esophageal Cancer	CCLE	DSVYLVPTP	DEG_COP1_1	112:120	Mutation rewiring degron network	0.1667
p.G126A	KYSE-140	oesophagus	COSMIC	DSVYLVPTP	DEG_COP1_1	112:120	Mutation rewiring degron network	0.1667
p.G124A	KYSE-140	oesophagus	COSMIC	DSVYLVPTP	DEG_COP1_1	112:120	Mutation rewiring degron network	0.2222
p.V292F	ABC-1	lung	COSMIC	GRDPLLEVY	DEG_APCC_DBOX_1	279:287	Mutation blocking phosphorylation signal	0.6389
p.V272F	ABC-1	lung	COSMIC	GRDPLLEVY	DEG_APCC_DBOX_1	279:287	Mutation rewiring degron network	0.1389
p.G126S	MOLM-13	haematopoietic and lymphoid tissue	COSMIC	DSVYLVPTP	DEG_COP1_1	112:120	Mutation rewiring degron network	0.1667
p.V126F	ABC-1	lung	COSMIC	DSVYLVPTP	DEG_COP1_1	112:120	Mutation rewiring degron network	0.1667
p.S278G	L-363	haematopoietic and lymphoid tissue	COSMIC	GRDPLLEVY	DEG_APCC_DBOX_1	279:287	Mutation rewiring degron network	0.3056
p.S306G	L-363	haematopoietic and lymphoid tissue	COSMIC	SVSKDVPDGP	DEG_COP1_1	311:320	Mutation blocking phosphorylation signal	0.6389
p.A109T	CW-2	large intestine	COSMIC	DSVYLVPTP	DEG_COP1_1	112:120	Mutation rewiring degron network	0.25
p.S112G	L-363	haematopoietic and lymphoid tissue	COSMIC	DSVYLVPTP	DEG_COP1_1	112:120	Mutation altering degron motif	0.6993
p.G124S	MOLM-13	haematopoietic and lymphoid tissue	COSMIC	DSVYLVPTP	DEG_COP1_1	112:120	Mutation rewiring degron network	0.2222

Kaplan plot for BCAR1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BCAR1

UniProt ID: P56945

Entrez ID: 9564

Protein name: Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BCAR1 in