DegronMD

Uniprot ID: P56945

Source protein: Breast cancer anti-estrogen resistance protein 1

Source gene: BCAR1

Class: DEG_APCC_DBOX_1

Location: 279:287

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9925

ASA_SCORE: 78.9222

COIL: 0.7979

CONS_SCORE: 0.3567

DSS_SCORE: 0.5413

HELIX: 0.1138

FCONS_SCORE: 0.9596

RIG_SCORE: 0.7345

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P283L	TCGA-BH-A18G	BRCA	TCGA	GRDPLLEVY	DEG_APCC_DBOX_1	0.7582
p.P283L	DO3686	BRCA	ICGC	GRDPLLEVY	DEG_APCC_DBOX_1	0.7582
p.E271K	TCGA-EO-A22U	UCEC	TCGA	GRDPLLEVY	DEG_APCC_DBOX_1	0.1111
p.E271K	DO43755	UCEC	ICGC	GRDPLLEVY	DEG_APCC_DBOX_1	0.1111
p.Y295C	TCGA-LN-A49S	ESCA	TCGA	GRDPLLEVY	DEG_APCC_DBOX_1	0.2222
p.L295R	DO9756	COAD	ICGC	GRDPLLEVY	DEG_APCC_DBOX_1	0.2222
p.R278Q	DO222840	COCA	ICGC	GRDPLLEVY	DEG_APCC_DBOX_1	0.3056
p.Q292K	DO229045	LICA	ICGC	GRDPLLEVY	DEG_APCC_DBOX_1	0.6389
p.P269H	DO232224	PBCA	ICGC	GRDPLLEVY	DEG_APCC_DBOX_1	0.5
p.G274C	DO37703	SKCM	ICGC	GRDPLLEVY	DEG_APCC_DBOX_1	0.1944
p.G274C	DO47407	SKCM	ICGC	GRDPLLEVY	DEG_APCC_DBOX_1	0.1944
p.M270V	DO42177	UCEC	ICGC	GRDPLLEVY	DEG_APCC_DBOX_1	0.0833
p.Y280H	SIDM01307	Colorectal Carcinoma	GDSC	GRDPLLEVY	DEG_APCC_DBOX_1	0.7229
p.V274F	ACH-000528	Lung Cancer	CCLE	GRDPLLEVY	DEG_APCC_DBOX_1	0.1944
p.V274F	ABC-1	lung	COSMIC	GRDPLLEVY	DEG_APCC_DBOX_1	0.1944
p.V292F	ABC-1	lung	COSMIC	GRDPLLEVY	DEG_APCC_DBOX_1	0.6389
p.V272F	ABC-1	lung	COSMIC	GRDPLLEVY	DEG_APCC_DBOX_1	0.1389
p.S278G	L-363	haematopoietic_and_lymphoid_tissue	COSMIC	GRDPLLEVY	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P56945	Breast cancer anti-estrogen resistance protein 1	DEG_APCC_DBOX_1	279:287	GRDPLLEVY	APC,CDC20,FZR1	0.9925	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons