DegronMD

Uniprot ID: P56945

Source protein: Breast cancer anti-estrogen resistance protein 1

Source gene: BCAR1

Class: DEG_COP1_1

Location: 311:320

E3 ligase: COP1

DEGRON score: 0.9992

ASA_SCORE: 81.31

COIL: 0.9336

CONS_SCORE: 0.2899

DSS_SCORE: 0.5441

HELIX: 0.0261

FCONS_SCORE: 0.7815

RIG_SCORE: 0.6619

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q307H	TCGA-55-8089	LUAD	TCGA	SVSKDVPDGP	DEG_COP1_1	0.2222
p.Q307H	DO23690	LUAD	ICGC	SVSKDVPDGP	DEG_COP1_1	0.2222
p.M318V	TCGA-AJ-A2QO	UCEC	TCGA	SVSKDVPDGP	DEG_COP1_1	0.7208
p.R301W	TCGA-CA-6718	COAD	TCGA	SVSKDVPDGP	DEG_COP1_1	0.0556
p.R301W	SIDM01617	Endometrial Carcinoma	GDSC	SVSKDVPDGP	DEG_COP1_1	0.0556
p.G322C	TCGA-D3-A2JP	SKCM	TCGA	SVSKDVPDGP	DEG_COP1_1	0.2778
p.G322C	TCGA-FS-A1ZP	SKCM	TCGA	SVSKDVPDGP	DEG_COP1_1	0.2778
p.K321N	TCGA-D3-A2JP	SKCM	TCGA	SVSKDVPDGP	DEG_COP1_1	0.3056
p.K321N	DO47407	SKCM	ICGC	SVSKDVPDGP	DEG_COP1_1	0.3056
p.Y305C	DO5326	BRCA	ICGC	SVSKDVPDGP	DEG_COP1_1	0.1667
p.A322T	DO230326	COCA	ICGC	SVSKDVPDGP	DEG_COP1_1	0.2778
p.P316S	DO233207	GACA	ICGC	SVSKDVPDGP	DEG_COP1_1	0.6752
p.Q310K	DO229036	LICA	ICGC	SVSKDVPDGP	DEG_COP1_1	0.3056
p.Y324H	DO220073	SARC	ICGC	SVSKDVPDGP	DEG_COP1_1	0.2222
p.R317K	DO43755	UCEC	ICGC	SVSKDVPDGP	DEG_COP1_1	0.7237
p.P305L	SIDM01175	Other Sarcomas	GDSC	SVSKDVPDGP	DEG_COP1_1	0.1667
p.V320F	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	SVSKDVPDGP	DEG_COP1_1	0.7068
p.V320F	ABC-1	lung	COSMIC	SVSKDVPDGP	DEG_COP1_1	0.7068
p.A312V	SIDM00217	Colorectal Carcinoma	GDSC	SVSKDVPDGP	DEG_COP1_1	0.6936
p.A312V	SNU-1040	large_intestine	COSMIC	SVSKDVPDGP	DEG_COP1_1	0.6936
p.N324S	SIDM01686	Chronic Myelogenous Leukemia	GDSC	SVSKDVPDGP	DEG_COP1_1	0.2222
p.K314M	ACH-000207	Head and Neck Cancer	CCLE	SVSKDVPDGP	DEG_COP1_1	0.6951
p.S306G	L-363	haematopoietic_and_lymphoid_tissue	COSMIC	SVSKDVPDGP	DEG_COP1_1	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P56945	Breast cancer anti-estrogen resistance protein 1	DEG_COP1_1	311:320	SVSKDVPDGP	COP1	0.9992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons