DegronMD

Uniprot ID: P17542

Source protein: T-cell acute lymphocytic leukemia protein 1

Source gene: TAL1

Class: CBL_PTK

Location: 302:308

E3 ligase: CBL

DEGRON score: 0.7483

ASA_SCORE: 87.1714

COIL: 0.8897

CONS_SCORE: 0.366

DSS_SCORE: 0.6891

HELIX: 0.0791

FCONS_SCORE: 0.9964

RIG_SCORE: 0.6088

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S300N	TCGA-02-2466	GBM	TCGA	DSYTEEP	CBL_PTK	0.2778
p.T305K	TCGA-34-5241	LUSC	TCGA	DSYTEEP	CBL_PTK	0.7306
p.A309E	TCGA-86-8359	LUAD	TCGA	DSYTEEP	CBL_PTK	0.3056
p.S303R	TCGA-AG-3891	READ	TCGA	DSYTEEP	CBL_PTK	0.6316
p.A309V	TCGA-AZ-5407	COAD	TCGA	DSYTEEP	CBL_PTK	0.3056
p.A309V	SIDM01619	Endometrial Carcinoma	GDSC	DSYTEEP	CBL_PTK	0.3056
p.T313K	TCGA-B9-5155	KIRP	TCGA	DSYTEEP	CBL_PTK	0.1944
p.P308H	TCGA-BA-A6DA	HNSC	TCGA	DSYTEEP	CBL_PTK	0.7694
p.S293I	TCGA-BS-A0UF	UCEC	TCGA	DSYTEEP	CBL_PTK	0.0833
p.G297E	TCGA-D3-A51G	SKCM	TCGA	DSYTEEP	CBL_PTK	0.1944
p.G297V	TCGA-EE-A184	SKCM	TCGA	DSYTEEP	CBL_PTK	0.1944
p.D296Y	TCGA-NJ-A4YG	LUAD	TCGA	DSYTEEP	CBL_PTK	0.1667
p.D296Y	DO218941	LUAD	ICGC	DSYTEEP	CBL_PTK	0.1667
p.A311V	DO227473	BRCA	ICGC	DSYTEEP	CBL_PTK	0.3611
p.A311V	DO8432	COAD	ICGC	DSYTEEP	CBL_PTK	0.3611
p.C293Y	DO219728	CESC	ICGC	DSYTEEP	CBL_PTK	0.0833
p.A316T	DO230311	COCA	ICGC	DSYTEEP	CBL_PTK	0.5556
p.S302N	DO13480	GBM	ICGC	DSYTEEP	CBL_PTK	0.7069
p.P310H	DO44448	HNSC	ICGC	DSYTEEP	CBL_PTK	0.2778
p.T315K	DO20843	KIRP	ICGC	DSYTEEP	CBL_PTK	0.1389
p.P310T	DO44692	LICA	ICGC	DSYTEEP	CBL_PTK	0.2778
p.A311E	DO25817	LUAD	ICGC	DSYTEEP	CBL_PTK	0.3611
p.T307K	DO27341	LUSC	ICGC	DSYTEEP	CBL_PTK	0.7306
p.P308L	DO220900	MELA	ICGC	DSYTEEP	CBL_PTK	0.7582
p.P303Q	DO233298	NACA	ICGC	DSYTEEP	CBL_PTK	0.7035
p.S305R	DO36388	READ	ICGC	DSYTEEP	CBL_PTK	0.7427
p.G299E	DO47700	SKCM	ICGC	DSYTEEP	CBL_PTK	0.25
p.G299V	DO47442	SKCM	ICGC	DSYTEEP	CBL_PTK	0.25
p.S295I	DO41488	UCEC	ICGC	DSYTEEP	CBL_PTK	0.1389
p.A314T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	DSYTEEP	CBL_PTK	0.1667
p.A314T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	DSYTEEP	CBL_PTK	0.1667
p.A314T	ACH-000995	Leukemia	CCLE	DSYTEEP	CBL_PTK	0.1667
p.A314T	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	DSYTEEP	CBL_PTK	0.1667
p.T305M	SIDM00352	Ovarian Carcinoma	GDSC	DSYTEEP	CBL_PTK	0.7423
p.T305M	ACH-000719	Ovarian Cancer	CCLE	DSYTEEP	CBL_PTK	0.7423
p.T305M	RMG-I	ovary	COSMIC	DSYTEEP	CBL_PTK	0.7423
p.A309S	SIDM00096	T-Cell Non-Hodgkin's Lymphoma	GDSC	DSYTEEP	CBL_PTK	0.3056
p.A309S	SIDM00227	Neuroblastoma	GDSC	DSYTEEP	CBL_PTK	0.3056
p.D302Y	SIDM01149	Small Cell Lung Carcinoma	GDSC	DSYTEEP	CBL_PTK	0.7325
p.D302Y	ACH-001365	Lung Cancer	CCLE	DSYTEEP	CBL_PTK	0.7325
p.D302Y	NCI-H847	lung	COSMIC	DSYTEEP	CBL_PTK	0.7325
p.T313A	SIDM00333	Endometrial Carcinoma	GDSC	DSYTEEP	CBL_PTK	0.1944
p.T313A	ACH-000988	Endometrial/Uterine Cancer	CCLE	DSYTEEP	CBL_PTK	0.1944
p.T313A	MFE-319	endometrium	COSMIC	DSYTEEP	CBL_PTK	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSYTEEP

Degron related mutations and impact score

Drug responses associated with TAL1 mutations

All proteins holding degron of DSYTEEP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17542	T-cell acute lymphocytic leukemia protein 1	CBL_PTK	302:308	DSYTEEP	CBL	0.7483	More...