DegronMD - P17542(TAL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S300N	TCGA-02-2466	GBM	TCGA	DSYTEEP	CBL_PTK	302:308	Mutation rewiring degron network	0.2778
p.T305K	TCGA-34-5241	LUSC	TCGA	DSYTEEP	CBL_PTK	302:308	Mutation altering degron motif	0.7306
p.A309E	TCGA-86-8359	LUAD	TCGA	DSYTEEP	CBL_PTK	302:308	Mutation rewiring degron network	0.3056
p.S303R	TCGA-AG-3891	READ	TCGA	DSYTEEP	CBL_PTK	302:308	Mutation altering degron motif	0.6316
p.A309V	TCGA-AZ-5407	COAD	TCGA	DSYTEEP	CBL_PTK	302:308	Mutation rewiring degron network	0.3056
p.A309V	SIDM01619	Endometrial Carcinoma	GDSC	DSYTEEP	CBL_PTK	302:308	Mutation rewiring degron network	0.3056
p.T313K	TCGA-B9-5155	KIRP	TCGA	DSYTEEP	CBL_PTK	302:308	Mutation rewiring degron network	0.1944
p.P308H	TCGA-BA-A6DA	HNSC	TCGA	DSYTEEP	CBL_PTK	302:308	Mutation altering degron motif	0.7694
p.S293I	TCGA-BS-A0UF	UCEC	TCGA	DSYTEEP	CBL_PTK	302:308	Mutation rewiring degron network	0.0833
p.G297E	TCGA-D3-A51G	SKCM	TCGA	DSYTEEP	CBL_PTK	302:308	Mutation rewiring degron network	0.1944
p.G297V	TCGA-EE-A184	SKCM	TCGA	DSYTEEP	CBL_PTK	302:308	Mutation rewiring degron network	0.1944
p.F151L	TCGA-EO-A22X	UCEC	TCGA	GRALLYSLS	DEG_APCC_DBOX_1	133:141	Mutation rewiring degron network	0.0556
p.D296Y	TCGA-NJ-A4YG	LUAD	TCGA	DSYTEEP	CBL_PTK	302:308	Mutation rewiring degron network	0.1667
p.D296Y	DO218941	LUAD	ICGC	DSYTEEP	CBL_PTK	302:308	Mutation rewiring degron network	0.1667
p.A311V	DO227473	BRCA	ICGC	DSYTEEP	CBL_PTK	302:308	Mutation substituting flanking lysine	0.3611
p.A311V	DO8432	COAD	ICGC	DSYTEEP	CBL_PTK	302:308	Mutation substituting flanking lysine	0.3611
p.C293Y	DO219728	CESC	ICGC	DSYTEEP	CBL_PTK	302:308	Mutation rewiring degron network	0.0833
p.A316T	DO230311	COCA	ICGC	DSYTEEP	CBL_PTK	302:308	Mutation blocking phosphorylation signal	0.5556
p.A125T	DO234235	ESAD	ICGC	GRALLYSLS	DEG_APCC_DBOX_1	133:141	Mutation rewiring degron network	0.1111
p.A130T	DO234235	ESAD	ICGC	GRALLYSLS	DEG_APCC_DBOX_1	133:141	Mutation rewiring degron network	0.25
p.S302N	DO13480	GBM	ICGC	DSYTEEP	CBL_PTK	302:308	Mutation altering degron motif	0.7069
p.P310H	DO44448	HNSC	ICGC	DSYTEEP	CBL_PTK	302:308	Mutation rewiring degron network	0.2778
p.T315K	DO20843	KIRP	ICGC	DSYTEEP	CBL_PTK	302:308	Mutation rewiring degron network	0.1389
p.P310T	DO44692	LICA	ICGC	DSYTEEP	CBL_PTK	302:308	Mutation rewiring degron network	0.2778
p.A311E	DO25817	LUAD	ICGC	DSYTEEP	CBL_PTK	302:308	Mutation substituting flanking lysine	0.3611
p.T307K	DO27341	LUSC	ICGC	DSYTEEP	CBL_PTK	302:308	Mutation altering degron motif	0.7306
p.P308L	DO220900	MELA	ICGC	DSYTEEP	CBL_PTK	302:308	Mutation altering degron motif	0.7582
p.P303Q	DO233298	NACA	ICGC	DSYTEEP	CBL_PTK	302:308	Mutation altering degron motif	0.7035
p.S305R	DO36388	READ	ICGC	DSYTEEP	CBL_PTK	302:308	Mutation altering degron motif	0.7427
p.G299E	DO47700	SKCM	ICGC	DSYTEEP	CBL_PTK	302:308	Mutation rewiring degron network	0.25
p.G299V	DO47442	SKCM	ICGC	DSYTEEP	CBL_PTK	302:308	Mutation rewiring degron network	0.25
p.S295I	DO41488	UCEC	ICGC	DSYTEEP	CBL_PTK	302:308	Mutation rewiring degron network	0.1389
p.A314T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	DSYTEEP	CBL_PTK	302:308	Mutation rewiring degron network	0.1667
p.A314T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	DSYTEEP	CBL_PTK	302:308	Mutation rewiring degron network	0.1667
p.A314T	ACH-000995	Leukemia	CCLE	DSYTEEP	CBL_PTK	302:308	Mutation rewiring degron network	0.1667
p.A314T	Jurkat	haematopoietic and lymphoid tissue	COSMIC	DSYTEEP	CBL_PTK	302:308	Mutation rewiring degron network	0.1667
p.T305M	SIDM00352	Ovarian Carcinoma	GDSC	DSYTEEP	CBL_PTK	302:308	Mutation altering degron motif	0.7423
p.T305M	ACH-000719	Ovarian Cancer	CCLE	DSYTEEP	CBL_PTK	302:308	Mutation altering degron motif	0.7423
p.T305M	RMG-I	ovary	COSMIC	DSYTEEP	CBL_PTK	302:308	Mutation altering degron motif	0.7423
p.A309S	SIDM00096	T-Cell Non-Hodgkin's Lymphoma	GDSC	DSYTEEP	CBL_PTK	302:308	Mutation rewiring degron network	0.3056
p.A309S	SIDM00227	Neuroblastoma	GDSC	DSYTEEP	CBL_PTK	302:308	Mutation rewiring degron network	0.3056
p.D302Y	SIDM01149	Small Cell Lung Carcinoma	GDSC	DSYTEEP	CBL_PTK	302:308	Mutation altering degron motif	0.7325
p.D302Y	ACH-001365	Lung Cancer	CCLE	DSYTEEP	CBL_PTK	302:308	Mutation altering degron motif	0.7325
p.D302Y	NCI-H847	lung	COSMIC	DSYTEEP	CBL_PTK	302:308	Mutation altering degron motif	0.7325
p.T313A	SIDM00333	Endometrial Carcinoma	GDSC	DSYTEEP	CBL_PTK	302:308	Mutation rewiring degron network	0.1944
p.T313A	ACH-000988	Endometrial/Uterine Cancer	CCLE	DSYTEEP	CBL_PTK	302:308	Mutation rewiring degron network	0.1944
p.T313A	MFE-319	endometrium	COSMIC	DSYTEEP	CBL_PTK	302:308	Mutation rewiring degron network	0.1944
p.S146T	ACH-000751	Leukemia	CCLE	GRALLYSLS	DEG_APCC_DBOX_1	133:141	Mutation blocking phosphorylation signal	0.6389
p.P124S	ACH-001306	Thyroid Cancer	CCLE	GRALLYSLS	DEG_APCC_DBOX_1	133:141	Mutation rewiring degron network	0.0833

Kaplan plot for TAL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TAL1

UniProt ID: P17542

Entrez ID: 6886

Protein name: T-cell acute lymphocytic leukemia protein 1 (TAL-1) (Class A basic helix-loop-helix protein 17) (bHLHa17) (Stem cell protein) (T-cell leukemia/lymphoma protein 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TAL1 in