DegronMD

Uniprot ID: P17542

Source protein: T-cell acute lymphocytic leukemia protein 1

Source gene: TAL1

Class: DEG_APCC_DBOX_1

Location: 133:141

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9701

ASA_SCORE: 71.5111

COIL: 0.7567

CONS_SCORE: 0.4021

DSS_SCORE: 0.2069

HELIX: 0.1609

FCONS_SCORE: 1.0429

RIG_SCORE: 0.7758

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F151L	TCGA-EO-A22X	UCEC	TCGA	GRALLYSLS	DEG_APCC_DBOX_1	0.0556
p.A125T	DO234235	ESAD	ICGC	GRALLYSLS	DEG_APCC_DBOX_1	0.1111
p.A130T	DO234235	ESAD	ICGC	GRALLYSLS	DEG_APCC_DBOX_1	0.25
p.S146T	ACH-000751	Leukemia	CCLE	GRALLYSLS	DEG_APCC_DBOX_1	0.6389
p.P124S	ACH-001306	Thyroid Cancer	CCLE	GRALLYSLS	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17542	T-cell acute lymphocytic leukemia protein 1	DEG_APCC_DBOX_1	133:141	GRALLYSLS	APC,CDC20,FZR1	0.9701	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons