DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
DTCYSPKP
Uniprot ID:
Q9Y5K6
Source protein:
CD2-associated protein
Source gene:
CD2AP
Class:
CBL_PTK
Location:
538:545
E3 ligase:
CBL
DEGRON score:
0.9977
ASA_SCORE:
99.15
COIL:
0.9528
CONS_SCORE:
0.431
DSS_SCORE:
0.4451
HELIX:
0.0266
FCONS_SCORE:
0.9997
RIG_SCORE:
0.7071
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.C540W
TCGA-D7-A4YT
STAD
TCGA
DTCYSPKP
CBL_PTK
0.5889
p.C540W
DO47723
STAD
ICGC
DTCYSPKP
CBL_PTK
0.5889
p.Y541H
TCGA-VQ-A91U
STAD
TCGA
DTCYSPKP
CBL_PTK
0.834
p.Y541H
DO51787
STAD
ICGC
DTCYSPKP
CBL_PTK
0.834
p.V547L
DO44090
COAD
ICGC
DTCYSPKP
CBL_PTK
0.2778
p.V547M
DO230326
COCA
ICGC
DTCYSPKP
CBL_PTK
0.2778
p.K544M
DO228828
LICA
ICGC
DTCYSPKP
CBL_PTK
0.6951
p.A528S
DO229015
LICA
ICGC
DTCYSPKP
CBL_PTK
0.0556
p.P543L
DO231152
LUSC
ICGC
DTCYSPKP
CBL_PTK
0.6471
p.Y548H
DO232224
PBCA
ICGC
DTCYSPKP
CBL_PTK
0.6944
p.S546A
DO229540
UTCA
ICGC
DTCYSPKP
CBL_PTK
0.75
p.L549R
ACH-001369
Ovarian Cancer
CCLE
DTCYSPKP
CBL_PTK
0.2222
Drug responses associated with CD2AP mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DTCYSPKP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9Y5K6
CD2-associated protein
CBL_PTK
538:545
DTCYSPKP
CBL
0.9977
More...