DegronMD - Q9Y5K6(CD2AP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R46I	TCGA-AB-2839	LAML	TCGA	RRGMFPD	LIG_APCC_ABBAyCdc20_2	45:51	Mutation altering degron motif	0.6991
p.R46I	DO21827	LAML	ICGC	RRGMFPD	LIG_APCC_ABBAyCdc20_2	45:51	Mutation altering degron motif	0.6991
p.E312K	TCGA-AN-A046	BRCA	TCGA	SKETGE	DEG_Kelch_Keap1_1	300:305	Mutation rewiring degron network	0.1389
p.E312K	TCGA-BS-A0UV	UCEC	TCGA	SKETGE	DEG_Kelch_Keap1_1	300:305	Mutation rewiring degron network	0.1389
p.E312K	TCGA-EE-A29D	SKCM	TCGA	SKETGE	DEG_Kelch_Keap1_1	300:305	Mutation rewiring degron network	0.1389
p.E312K	DO1285	BRCA	ICGC	SKETGE	DEG_Kelch_Keap1_1	300:305	Mutation rewiring degron network	0.1389
p.E312K	DO38123	SKCM	ICGC	SKETGE	DEG_Kelch_Keap1_1	300:305	Mutation rewiring degron network	0.1389
p.E312K	DO42793	UCEC	ICGC	SKETGE	DEG_Kelch_Keap1_1	300:305	Mutation rewiring degron network	0.1389
p.E35G	TCGA-B5-A11E	UCEC	TCGA	RRGMFPD	LIG_APCC_ABBAyCdc20_2	45:51	Mutation rewiring degron network	0.0556
p.E35G	DO41644	UCEC	ICGC	RRGMFPD	LIG_APCC_ABBAyCdc20_2	45:51	Mutation rewiring degron network	0.0556
p.C540W	TCGA-D7-A4YT	STAD	TCGA	DTCYSPKP	CBL_PTK	538:545	Mutation altering degron motif	0.5889
p.C540W	DO47723	STAD	ICGC	DTCYSPKP	CBL_PTK	538:545	Mutation altering degron motif	0.5889
p.E41K	TCGA-O2-A52V	LUSC	TCGA	RRGMFPD	LIG_APCC_ABBAyCdc20_2	45:51	Mutation rewiring degron network	0.2222
p.E41K	DO219223	LUSC	ICGC	RRGMFPD	LIG_APCC_ABBAyCdc20_2	45:51	Mutation rewiring degron network	0.2222
p.K58E	TCGA-O2-A52V	LUSC	TCGA	RRGMFPD	LIG_APCC_ABBAyCdc20_2	45:51	Mutation substituting flanking lysine	0.25
p.K58E	DO219223	LUSC	ICGC	RRGMFPD	LIG_APCC_ABBAyCdc20_2	45:51	Mutation substituting flanking lysine	0.25
p.E35V	TCGA-Q2-A5QZ	KIRP	TCGA	RRGMFPD	LIG_APCC_ABBAyCdc20_2	45:51	Mutation rewiring degron network	0.0556
p.E35V	DO48502	KIRP	ICGC	RRGMFPD	LIG_APCC_ABBAyCdc20_2	45:51	Mutation rewiring degron network	0.0556
p.Y541H	TCGA-VQ-A91U	STAD	TCGA	DTCYSPKP	CBL_PTK	538:545	Mutation altering degron motif	0.834
p.Y541H	DO51787	STAD	ICGC	DTCYSPKP	CBL_PTK	538:545	Mutation altering degron motif	0.834
p.V547L	DO44090	COAD	ICGC	DTCYSPKP	CBL_PTK	538:545	Mutation rewiring degron network	0.2778
p.V547M	DO230326	COCA	ICGC	DTCYSPKP	CBL_PTK	538:545	Mutation rewiring degron network	0.2778
p.N43K	DO229016	COCA	ICGC	RRGMFPD	LIG_APCC_ABBAyCdc20_2	45:51	Mutation rewiring degron network	0.2778
p.T61M	DO233804	GACA	ICGC	RRGMFPD	LIG_APCC_ABBAyCdc20_2	45:51	Mutation rewiring degron network	0.0556
p.K544M	DO228828	LICA	ICGC	DTCYSPKP	CBL_PTK	538:545	Mutation altering degron motif	0.6951
p.A528S	DO229015	LICA	ICGC	DTCYSPKP	CBL_PTK	538:545	Mutation rewiring degron network	0.0556
p.G36V	DO229035	LICA	ICGC	RRGMFPD	LIG_APCC_ABBAyCdc20_2	45:51	Mutation rewiring degron network	0.0833
p.G40V	DO229045	LICA	ICGC	RRGMFPD	LIG_APCC_ABBAyCdc20_2	45:51	Mutation rewiring degron network	0.1944
p.P543L	DO231152	LUSC	ICGC	DTCYSPKP	CBL_PTK	538:545	Mutation altering degron motif	0.6471
p.G47R	DO46513	OV	ICGC	RRGMFPD	LIG_APCC_ABBAyCdc20_2	45:51	Mutation altering degron motif	0.6457
p.G315D	DO232761	PBCA	ICGC	SKETGE	DEG_Kelch_Keap1_1	300:305	Mutation rewiring degron network	0.0556
p.Y548H	DO232224	PBCA	ICGC	DTCYSPKP	CBL_PTK	538:545	Mutation blocking phosphorylation signal	0.6944
p.E302G	DO229232	THCA	ICGC	SKETGE	DEG_Kelch_Keap1_1	300:305	Mutation altering degron motif	0.7199
p.S546A	DO229540	UTCA	ICGC	DTCYSPKP	CBL_PTK	538:545	Mutation blocking phosphorylation signal	0.75
p.E35K	SIDM00108	Melanoma	GDSC	RRGMFPD	LIG_APCC_ABBAyCdc20_2	45:51	Mutation rewiring degron network	0.0556
p.E35K	ACH-000579	Skin Cancer	CCLE	RRGMFPD	LIG_APCC_ABBAyCdc20_2	45:51	Mutation rewiring degron network	0.0556
p.E35K	UACC-257	skin	COSMIC	RRGMFPD	LIG_APCC_ABBAyCdc20_2	45:51	Mutation rewiring degron network	0.0556
p.E302D	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	SKETGE	DEG_Kelch_Keap1_1	300:305	Mutation altering degron motif	0.5647
p.E302D	ACH-000789	Lung Cancer	CCLE	SKETGE	DEG_Kelch_Keap1_1	300:305	Mutation altering degron motif	0.5647
p.E302D	NCI-H810	lung	COSMIC	SKETGE	DEG_Kelch_Keap1_1	300:305	Mutation altering degron motif	0.5647
p.L549R	ACH-001369	Ovarian Cancer	CCLE	DTCYSPKP	CBL_PTK	538:545	Mutation rewiring degron network	0.2222

Kaplan plot for CD2AP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CD2AP

UniProt ID: Q9Y5K6

Entrez ID: 23607

Protein name: CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CD2AP in