DegronMD

Uniprot ID: Q9Y5K6

Source protein: CD2-associated protein

Source gene: CD2AP

Class: DEG_Kelch_Keap1_1

Location: 300:305

E3 ligase: KEAP1

DEGRON score: 0.6439

ASA_SCORE: 83.7667

COIL: 0.5998

CONS_SCORE: 0.4352

DSS_SCORE: 0.2635

HELIX: 0.0103

FCONS_SCORE: 0.704

RIG_SCORE: 0.7855

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E312K	TCGA-AN-A046	BRCA	TCGA	SKETGE	DEG_Kelch_Keap1_1	0.1389
p.E312K	TCGA-BS-A0UV	UCEC	TCGA	SKETGE	DEG_Kelch_Keap1_1	0.1389
p.E312K	TCGA-EE-A29D	SKCM	TCGA	SKETGE	DEG_Kelch_Keap1_1	0.1389
p.E312K	DO1285	BRCA	ICGC	SKETGE	DEG_Kelch_Keap1_1	0.1389
p.E312K	DO38123	SKCM	ICGC	SKETGE	DEG_Kelch_Keap1_1	0.1389
p.E312K	DO42793	UCEC	ICGC	SKETGE	DEG_Kelch_Keap1_1	0.1389
p.G315D	DO232761	PBCA	ICGC	SKETGE	DEG_Kelch_Keap1_1	0.0556
p.E302G	DO229232	THCA	ICGC	SKETGE	DEG_Kelch_Keap1_1	0.7199
p.E302D	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	SKETGE	DEG_Kelch_Keap1_1	0.5647
p.E302D	ACH-000789	Lung Cancer	CCLE	SKETGE	DEG_Kelch_Keap1_1	0.5647
p.E302D	NCI-H810	lung	COSMIC	SKETGE	DEG_Kelch_Keap1_1	0.5647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y5K6	CD2-associated protein	DEG_Kelch_Keap1_1	300:305	SKETGE	KEAP1	0.6439	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons