DegronMD

Uniprot ID: Q9Y5K6

Source protein: CD2-associated protein

Source gene: CD2AP

Class: LIG_APCC_ABBAyCdc20_2

Location: 45:51

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9594

ASA_SCORE: 70.1143

COIL: 0.2299

CONS_SCORE: 0.4389

DSS_SCORE: 0.3523

HELIX: 0.0289

FCONS_SCORE: 1.1956

RIG_SCORE: 0.7292

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R46I	TCGA-AB-2839	LAML	TCGA	RRGMFPD	LIG_APCC_ABBAyCdc20_2	0.6991
p.R46I	DO21827	LAML	ICGC	RRGMFPD	LIG_APCC_ABBAyCdc20_2	0.6991
p.E35G	TCGA-B5-A11E	UCEC	TCGA	RRGMFPD	LIG_APCC_ABBAyCdc20_2	0.0556
p.E35G	DO41644	UCEC	ICGC	RRGMFPD	LIG_APCC_ABBAyCdc20_2	0.0556
p.E41K	TCGA-O2-A52V	LUSC	TCGA	RRGMFPD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E41K	DO219223	LUSC	ICGC	RRGMFPD	LIG_APCC_ABBAyCdc20_2	0.2222
p.K58E	TCGA-O2-A52V	LUSC	TCGA	RRGMFPD	LIG_APCC_ABBAyCdc20_2	0.25
p.K58E	DO219223	LUSC	ICGC	RRGMFPD	LIG_APCC_ABBAyCdc20_2	0.25
p.E35V	TCGA-Q2-A5QZ	KIRP	TCGA	RRGMFPD	LIG_APCC_ABBAyCdc20_2	0.0556
p.E35V	DO48502	KIRP	ICGC	RRGMFPD	LIG_APCC_ABBAyCdc20_2	0.0556
p.N43K	DO229016	COCA	ICGC	RRGMFPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.T61M	DO233804	GACA	ICGC	RRGMFPD	LIG_APCC_ABBAyCdc20_2	0.0556
p.G36V	DO229035	LICA	ICGC	RRGMFPD	LIG_APCC_ABBAyCdc20_2	0.0833
p.G40V	DO229045	LICA	ICGC	RRGMFPD	LIG_APCC_ABBAyCdc20_2	0.1944
p.G47R	DO46513	OV	ICGC	RRGMFPD	LIG_APCC_ABBAyCdc20_2	0.6457
p.E35K	SIDM00108	Melanoma	GDSC	RRGMFPD	LIG_APCC_ABBAyCdc20_2	0.0556
p.E35K	ACH-000579	Skin Cancer	CCLE	RRGMFPD	LIG_APCC_ABBAyCdc20_2	0.0556
p.E35K	UACC-257	skin	COSMIC	RRGMFPD	LIG_APCC_ABBAyCdc20_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y5K6	CD2-associated protein	LIG_APCC_ABBAyCdc20_2	45:51	RRGMFPD	APC,CDC20,FZR1	0.9594	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons