DegronMD

Uniprot ID: Q9NSC2

Source protein: Sal-like protein 1

Source gene: SALL1

Class: DEG_COP1_1

Location: 1102:1112

E3 ligase: COP1

DEGRON score: 0.946

ASA_SCORE: 74.2

COIL: 0.8037

CONS_SCORE: 0.4177

DSS_SCORE: 0.6906

HELIX: 0.0332

FCONS_SCORE: 1.0198

RIG_SCORE: 0.5832

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1109Q	TCGA-46-3767	LUSC	TCGA	DTPTSHVPSGP	DEG_COP1_1	0.7035
p.P1109Q	DO26650	LUSC	ICGC	DTPTSHVPSGP	DEG_COP1_1	0.7035
p.S1096F	TCGA-90-A4ED	LUSC	TCGA	DTPTSHVPSGP	DEG_COP1_1	0.1667
p.S1096F	DO45482	LUSC	ICGC	DTPTSHVPSGP	DEG_COP1_1	0.1667
p.S1106R	TCGA-AJ-A2QO	UCEC	TCGA	DTPTSHVPSGP	DEG_COP1_1	0.6316
p.S1106R	DO42177	UCEC	ICGC	DTPTSHVPSGP	DEG_COP1_1	0.6316
p.V1093M	TCGA-AX-A1CE	UCEC	TCGA	DTPTSHVPSGP	DEG_COP1_1	0.0833
p.V1093M	DO234308	ESAD	ICGC	DTPTSHVPSGP	DEG_COP1_1	0.0833
p.V1093M	DO42280	UCEC	ICGC	DTPTSHVPSGP	DEG_COP1_1	0.0833
p.G1111W	TCGA-BF-A1PX	SKCM	TCGA	DTPTSHVPSGP	DEG_COP1_1	0.7825
p.G1111W	DO51236	SKCM	ICGC	DTPTSHVPSGP	DEG_COP1_1	0.7825
p.F1092C	TCGA-CA-6717	COAD	TCGA	DTPTSHVPSGP	DEG_COP1_1	0.0556
p.F1092C	DO8264	COAD	ICGC	DTPTSHVPSGP	DEG_COP1_1	0.0556
p.P1120S	TCGA-D3-A3CB	SKCM	TCGA	DTPTSHVPSGP	DEG_COP1_1	0.1111
p.P1120S	DO47386	SKCM	ICGC	DTPTSHVPSGP	DEG_COP1_1	0.1111
p.V1108D	TCGA-DD-AAEI	LIHC	TCGA	DTPTSHVPSGP	DEG_COP1_1	0.7785
p.V1108D	DO219575	LIHC	ICGC	DTPTSHVPSGP	DEG_COP1_1	0.7785
p.P1097S	TCGA-EE-A29B	SKCM	TCGA	DTPTSHVPSGP	DEG_COP1_1	0.1944
p.P1097S	DO47255	SKCM	ICGC	DTPTSHVPSGP	DEG_COP1_1	0.1944
p.L1122P	TCGA-HC-7752	PRAD	TCGA	DTPTSHVPSGP	DEG_COP1_1	0.0556
p.L1122P	DO36267	PRAD	ICGC	DTPTSHVPSGP	DEG_COP1_1	0.0556
p.D1099N	TCGA-WE-A8K5	SKCM	TCGA	DTPTSHVPSGP	DEG_COP1_1	0.25
p.D1099N	DO51282	SKCM	ICGC	DTPTSHVPSGP	DEG_COP1_1	0.25
p.G1104D	DO7776	COAD	ICGC	DTPTSHVPSGP	DEG_COP1_1	0.7198
p.P1109L	DO234185	ESAD	ICGC	DTPTSHVPSGP	DEG_COP1_1	0.7582
p.F1120V	DO48495	KIRP	ICGC	DTPTSHVPSGP	DEG_COP1_1	0.1111
p.A1094E	DO23907	LUAD	ICGC	DTPTSHVPSGP	DEG_COP1_1	0.1111
p.V1108I	DO230940	LUSC	ICGC	DTPTSHVPSGP	DEG_COP1_1	0.7076
p.V1108I	DO224584	LUSC	ICGC	DTPTSHVPSGP	DEG_COP1_1	0.7076
p.T1105I	DO222662	MELA	ICGC	DTPTSHVPSGP	DEG_COP1_1	0.7078
p.P1120A	DO222702	MELA	ICGC	DTPTSHVPSGP	DEG_COP1_1	0.1111
p.R1098W	DO51151	PRAD	ICGC	DTPTSHVPSGP	DEG_COP1_1	0.2222
p.R1098W	DO229502	SKCA	ICGC	DTPTSHVPSGP	DEG_COP1_1	0.2222
p.R1098W	DO43306	UCEC	ICGC	DTPTSHVPSGP	DEG_COP1_1	0.2222
p.T1092P	DO229456	SKCA	ICGC	DTPTSHVPSGP	DEG_COP1_1	0.0556
p.L1109I	DO40884	UCEC	ICGC	DTPTSHVPSGP	DEG_COP1_1	0.7174
p.R1099Q	DO43755	UCEC	ICGC	DTPTSHVPSGP	DEG_COP1_1	0.25
p.T1103P	ACH-001704	Skin Cancer	CCLE	DTPTSHVPSGP	DEG_COP1_1	0.5919

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DTPTSHVPSGP

Degron related mutations and impact score

Drug responses associated with SALL1 mutations

All proteins holding degron of DTPTSHVPSGP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NSC2	Sal-like protein 1	DEG_COP1_1	1102:1112	DTPTSHVPSGP	COP1	0.946	More...