DegronMD

Uniprot ID: Q8NC42

Source protein: E3 ubiquitin-protein ligase RNF149

Source gene: RNF149

Class: DEG_COP1_1

Location: 93:101

E3 ligase: COP1

DEGRON score: 0.9013

ASA_SCORE: 70.9778

COIL: 0.8874

CONS_SCORE: 0.3193

DSS_SCORE: 0.4375

HELIX: 0.0587

FCONS_SCORE: 0.7775

RIG_SCORE: 0.8141

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D86Y	TCGA-DK-A6AW	BLCA	TCGA	DTRFFVPEP	DEG_COP1_1	0.1389
p.D86Y	DO48566	BLCA	ICGC	DTRFFVPEP	DEG_COP1_1	0.1389
p.R104Q	DO225198	BRCA	ICGC	DTRFFVPEP	DEG_COP1_1	0.25
p.A107T	DO228936	LICA	ICGC	DTRFFVPEP	DEG_COP1_1	0.1667
p.D93N	DO228940	LICA	ICGC	DTRFFVPEP	DEG_COP1_1	0.6932
p.P83S	DO229123	NKTL	ICGC	DTRFFVPEP	DEG_COP1_1	0.0556
p.W109L	DO220122	SARC	ICGC	DTRFFVPEP	DEG_COP1_1	0.1111
p.G85R	SIDM00652	Small Cell Lung Carcinoma	GDSC	DTRFFVPEP	DEG_COP1_1	0.1111
p.G85R	ACH-000780	Lung Cancer	CCLE	DTRFFVPEP	DEG_COP1_1	0.1111
p.G85R	NCI-H1105	lung	COSMIC	DTRFFVPEP	DEG_COP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NC42	E3 ubiquitin-protein ligase RNF149	DEG_COP1_1	93:101	DTRFFVPEP	COP1	0.9013	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons