DegronMD

Uniprot ID: P14543

Source protein: Nidogen-1

Source gene: NID1

Class: DEG_COP1_1

Location: 324:331

E3 ligase: COP1

DEGRON score: 0.9986

ASA_SCORE: 71.85

COIL: 0.786

CONS_SCORE: 0.2761

DSS_SCORE: 0.4739

HELIX: 0.0344

FCONS_SCORE: 1.0063

RIG_SCORE: 0.7234

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S333Y	TCGA-49-AAR9	LUAD	TCGA	DTYSVPSV	DEG_COP1_1	0.2778
p.S333Y	DO218921	LUAD	ICGC	DTYSVPSV	DEG_COP1_1	0.2778
p.T339N	TCGA-4B-A93V	LUAD	TCGA	DTYSVPSV	DEG_COP1_1	0.1111
p.T339N	DO218926	LUAD	ICGC	DTYSVPSV	DEG_COP1_1	0.1111
p.Y326H	TCGA-A5-A0G1	UCEC	TCGA	DTYSVPSV	DEG_COP1_1	0.7229
p.Y326H	DO42472	UCEC	ICGC	DTYSVPSV	DEG_COP1_1	0.7229
p.L318V	TCGA-AO-A0J6	BRCA	TCGA	DTYSVPSV	DEG_COP1_1	0.1667
p.L318V	DO4233	BRCA	ICGC	DTYSVPSV	DEG_COP1_1	0.1667
p.R336W	TCGA-D1-A177	UCEC	TCGA	DTYSVPSV	DEG_COP1_1	0.1944
p.R336W	TCGA-EO-A3B0	UCEC	TCGA	DTYSVPSV	DEG_COP1_1	0.1944
p.R336W	DO219773	UCEC	ICGC	DTYSVPSV	DEG_COP1_1	0.1944
p.R336W	DO42528	UCEC	ICGC	DTYSVPSV	DEG_COP1_1	0.1944
p.S330C	TCGA-DD-AACI	LIHC	TCGA	DTYSVPSV	DEG_COP1_1	0.7541
p.S330C	DO52205	LIHC	ICGC	DTYSVPSV	DEG_COP1_1	0.7541
p.R336Q	TCGA-DF-A2KU	UCEC	TCGA	DTYSVPSV	DEG_COP1_1	0.1944
p.R336Q	DO223286	UCEC	ICGC	DTYSVPSV	DEG_COP1_1	0.1944
p.T339A	TCGA-DI-A1BU	UCEC	TCGA	DTYSVPSV	DEG_COP1_1	0.1111
p.T339A	DO42023	UCEC	ICGC	DTYSVPSV	DEG_COP1_1	0.1111
p.K316R	DO234254	ESAD	ICGC	DTYSVPSV	DEG_COP1_1	0.2222
p.R319G	DO234304	ESAD	ICGC	DTYSVPSV	DEG_COP1_1	0.1944
p.K316T	DO233804	GACA	ICGC	DTYSVPSV	DEG_COP1_1	0.2222
p.P334T	DO229027	LICA	ICGC	DTYSVPSV	DEG_COP1_1	0.25
p.A317D	DO229031	LICA	ICGC	DTYSVPSV	DEG_COP1_1	0.1389
p.P334S	DO229177	LMS	ICGC	DTYSVPSV	DEG_COP1_1	0.25
p.R335C	DO228353	MALY	ICGC	DTYSVPSV	DEG_COP1_1	0.2222
p.R335C	SIDM00994	T-Lymphoblastic Leukemia	GDSC	DTYSVPSV	DEG_COP1_1	0.2222
p.R335C	ALL-SIL	haematopoietic_and_lymphoid_tissue	COSMIC	DTYSVPSV	DEG_COP1_1	0.2222
p.S314F	DO220891	MELA	ICGC	DTYSVPSV	DEG_COP1_1	0.0556
p.A337E	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	DTYSVPSV	DEG_COP1_1	0.1667
p.A337E	ACH-000789	Lung Cancer	CCLE	DTYSVPSV	DEG_COP1_1	0.1667
p.A337E	NCI-H810	lung	COSMIC	DTYSVPSV	DEG_COP1_1	0.1667
p.V331I	SIDM01146	Gastric Carcinoma	GDSC	DTYSVPSV	DEG_COP1_1	0.5965
p.V331I	NCI-SNU-1	stomach	COSMIC	DTYSVPSV	DEG_COP1_1	0.5965

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DTYSVPSV

Degron related mutations and impact score

Drug responses associated with NID1 mutations

All proteins holding degron of DTYSVPSV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P14543	Nidogen-1	DEG_COP1_1	324:331	DTYSVPSV	COP1	0.9986	More...