DegronMD - P14543(NID1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T311M	TCGA-44-7670	LUAD	TCGA	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.2778
p.T311M	TCGA-EA-A410	CESC	TCGA	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.2778
p.T311M	DO49929	CESC	ICGC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.2778
p.T311M	DO23555	LUAD	ICGC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.2778
p.T311M	SIDM00607	Glioblastoma	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.2778
p.T311M	KNS-42	central nervous system	COSMIC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.2778
p.S333Y	TCGA-49-AAR9	LUAD	TCGA	DTYSVPSV	DEG_COP1_1	324:331	Mutation rewiring degron network	0.2778
p.S333Y	DO218921	LUAD	ICGC	DTYSVPSV	DEG_COP1_1	324:331	Mutation rewiring degron network	0.2778
p.T339N	TCGA-4B-A93V	LUAD	TCGA	DTYSVPSV	DEG_COP1_1	324:331	Mutation rewiring degron network	0.1111
p.T339N	DO218926	LUAD	ICGC	DTYSVPSV	DEG_COP1_1	324:331	Mutation rewiring degron network	0.1111
p.Y326H	TCGA-A5-A0G1	UCEC	TCGA	DTYSVPSV	DEG_COP1_1	324:331	Mutation altering degron motif	0.7229
p.Y326H	DO42472	UCEC	ICGC	DTYSVPSV	DEG_COP1_1	324:331	Mutation altering degron motif	0.7229
p.L318V	TCGA-AO-A0J6	BRCA	TCGA	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.0833
p.L318V	TCGA-AO-A0J6	BRCA	TCGA	DTYSVPSV	DEG_COP1_1	324:331	Mutation rewiring degron network	0.1667
p.L318V	DO4233	BRCA	ICGC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.0833
p.L318V	DO4233	BRCA	ICGC	DTYSVPSV	DEG_COP1_1	324:331	Mutation rewiring degron network	0.1667
p.R336W	TCGA-D1-A177	UCEC	TCGA	DTYSVPSV	DEG_COP1_1	324:331	Mutation rewiring degron network	0.1944
p.R336W	TCGA-EO-A3B0	UCEC	TCGA	DTYSVPSV	DEG_COP1_1	324:331	Mutation rewiring degron network	0.1944
p.R336W	DO219773	UCEC	ICGC	DTYSVPSV	DEG_COP1_1	324:331	Mutation rewiring degron network	0.1944
p.R336W	DO42528	UCEC	ICGC	DTYSVPSV	DEG_COP1_1	324:331	Mutation rewiring degron network	0.1944
p.S330C	TCGA-DD-AACI	LIHC	TCGA	DTYSVPSV	DEG_COP1_1	324:331	Mutation altering degron motif	0.7541
p.S330C	DO52205	LIHC	ICGC	DTYSVPSV	DEG_COP1_1	324:331	Mutation altering degron motif	0.7541
p.R336Q	TCGA-DF-A2KU	UCEC	TCGA	DTYSVPSV	DEG_COP1_1	324:331	Mutation rewiring degron network	0.1944
p.R336Q	DO223286	UCEC	ICGC	DTYSVPSV	DEG_COP1_1	324:331	Mutation rewiring degron network	0.1944
p.T339A	TCGA-DI-A1BU	UCEC	TCGA	DTYSVPSV	DEG_COP1_1	324:331	Mutation rewiring degron network	0.1111
p.T339A	DO42023	UCEC	ICGC	DTYSVPSV	DEG_COP1_1	324:331	Mutation rewiring degron network	0.1111
p.E306D	TCGA-IB-7651	PAAD	TCGA	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.5647
p.E306D	TCGA-VQ-AA6J	STAD	TCGA	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.5647
p.E306D	DO46657	PAAD	ICGC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.5647
p.E306D	DO51802	STAD	ICGC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.5647
p.G304C	TCGA-MN-A4N4	LUAD	TCGA	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.6489
p.G304C	DO26250	LUAD	ICGC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.6489
p.A299V	DO227774	COCA	ICGC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.2778
p.A299V	DO222523	COCA	ICGC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.2778
p.A299V	SIDM00660	Colorectal Carcinoma	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.2778
p.A299V	SIDM01397	Melanoma	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.2778
p.Y296C	DO227987	COCA	ICGC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.1944
p.K316R	DO234254	ESAD	ICGC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation substituting flanking lysine	0.25
p.K316R	DO234254	ESAD	ICGC	DTYSVPSV	DEG_COP1_1	324:331	Mutation substituting flanking lysine	0.2222
p.R319G	DO234304	ESAD	ICGC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.0556
p.R319G	DO234304	ESAD	ICGC	DTYSVPSV	DEG_COP1_1	324:331	Mutation rewiring degron network	0.1944
p.K316T	DO233804	GACA	ICGC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation substituting flanking lysine	0.25
p.K316T	DO233804	GACA	ICGC	DTYSVPSV	DEG_COP1_1	324:331	Mutation substituting flanking lysine	0.2222
p.P334T	DO229027	LICA	ICGC	DTYSVPSV	DEG_COP1_1	324:331	Mutation rewiring degron network	0.25
p.A317D	DO229031	LICA	ICGC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.1111
p.A317D	DO229031	LICA	ICGC	DTYSVPSV	DEG_COP1_1	324:331	Mutation rewiring degron network	0.1389
p.P334S	DO229177	LMS	ICGC	DTYSVPSV	DEG_COP1_1	324:331	Mutation rewiring degron network	0.25
p.R335C	DO228353	MALY	ICGC	DTYSVPSV	DEG_COP1_1	324:331	Mutation rewiring degron network	0.2222
p.R335C	SIDM00994	T-Lymphoblastic Leukemia	GDSC	DTYSVPSV	DEG_COP1_1	324:331	Mutation rewiring degron network	0.2222
p.R335C	ALL-SIL	haematopoietic and lymphoid tissue	COSMIC	DTYSVPSV	DEG_COP1_1	324:331	Mutation rewiring degron network	0.2222
p.S314F	DO220891	MELA	ICGC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.1944
p.S314F	DO220891	MELA	ICGC	DTYSVPSV	DEG_COP1_1	324:331	Mutation rewiring degron network	0.0556
p.R302C	DO222743	MELA	ICGC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.8301
p.R302H	SIDM00672	Hepatocellular Carcinoma	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.8244
p.R302H	SIDM01090	Colorectal Carcinoma	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.8244
p.R302H	SIDM01126	Small Cell Lung Carcinoma	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.8244
p.R302H	SIDM00656	Burkitt's Lymphoma	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.8244
p.R302H	SIDM00849	Kidney Carcinoma	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.8244
p.R302H	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.8244
p.R302H	SIDM00032	Bladder Carcinoma	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.8244
p.R302H	SIDM01133	Other Solid Cancers	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.8244
p.R302H	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.8244
p.R302H	SIDM00863	Burkitt's Lymphoma	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.8244
p.R302H	SIDM00641	Burkitt's Lymphoma	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.8244
p.R302H	SIDM01686	Chronic Myelogenous Leukemia	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.8244
p.R302H	SIDM01664	Prostate Carcinoma	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.8244
p.R302H	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.8244
p.R302H	SIDM01752	Pancreatic Carcinoma	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.8244
p.F313L	SIDM00791	Chronic Myelogenous Leukemia	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.2222
p.F313L	ACH-000551	Leukemia	CCLE	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.2222
p.F313L	ACH-002061	Leukemia	CCLE	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.2222
p.F313L	K-562	haematopoietic and lymphoid tissue	COSMIC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.2222
p.A337E	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	DTYSVPSV	DEG_COP1_1	324:331	Mutation rewiring degron network	0.1667
p.A337E	ACH-000789	Lung Cancer	CCLE	DTYSVPSV	DEG_COP1_1	324:331	Mutation rewiring degron network	0.1667
p.A337E	NCI-H810	lung	COSMIC	DTYSVPSV	DEG_COP1_1	324:331	Mutation rewiring degron network	0.1667
p.D293N	SIDM00806	Osteosarcoma	GDSC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.1111
p.D293N	ACH-000613	Bone Cancer	CCLE	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.1111
p.D293N	ACH-001001	Bone Cancer	CCLE	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.1111
p.D293N	HOS	bone	COSMIC	TRLGLEDVG	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.1111
p.V331I	SIDM01146	Gastric Carcinoma	GDSC	DTYSVPSV	DEG_COP1_1	324:331	Mutation altering degron motif	0.5965
p.V331I	NCI-SNU-1	stomach	COSMIC	DTYSVPSV	DEG_COP1_1	324:331	Mutation altering degron motif	0.5965

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NID1

UniProt ID: P14543

Entrez ID: 4811

Protein name: Nidogen-1 (NID-1) (Entactin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NID1 in